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Metabolic effects of secretin.

Abstract：

:Secretin (Sct), traditionally a gastrointestinal hormone backed by a century long research, is now beginning to be recognized also as a neuroactive peptide. Substantiation by recent evidence on the functional role of Sct in various regions of the brain, especially on its potential neurosecretion from the posterior pituitary, has revealed Sct's physiological actions in regulating water homeostasis. Recent advances in understanding the functional roles of central and peripheral Sct has been made possible by the development of Sct and Sct receptor (SctR) knockout animal models which have led to novel approaches in research on the physiology of this brain-gut peptide. While research on the role of Sct in appetite regulation and fatty acid metabolism has been initiated recently, its role in glucose homeostasis is unclear. This review focuses mainly on the metabolic role of Sct by discussing data from the last century and recent discoveries, with emphasis on the need for revisiting and elucidating the role of Sct in metabolism and energy homeostasis.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Sekar R,Chow BK

doi

10.1016/j.ygcen.2012.11.017

subject

Has Abstract

pub_date

2013-01-15 00:00:00

pages

18-24

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(12)00452-2

journal_volume

181

pub_type

杂志文章,评审

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