An adipoinductive role of inflammation in adipose tissue engineering: key factors in the early development of engineered soft tissues.

abstract：:Human embryonic stem (hES) cells represent a potentially unlimited source of transplantable beta-cells for the treatment of diabetes. Here we describe a differentiation strategy that reproducibly directs HES3, an National Institutes of Health (NIH)-registered hES cell line, into cells of the pancreatic endocrine linea...

journal_title：Stem cells and development

authors： Phillips BW,Hentze H,Rust WL,Chen QP,Chipperfield H,Tan EK,Abraham S,Sadasivam A,Soong PL,Wang ST,Lim R,Sun W,Colman A,Dunn NR

更新日期：2007-08-01 00:00:00

abstract：:Periodontium is consisted of root cementum, bone lining the tooth socket, gingiva facing the tooth, and periodontal ligament (PDL). Its primary functions are support of the tooth and protection of tooth, nerve, and blood vessels from injury by mechanical loading. Severe periodontitis induces the destruction of periodo...

journal_title：Stem cells and development

authors： Tomokiyo A,Wada N,Maeda H

更新日期：2019-08-01 00:00:00

abstract：:Electrical stimulation (ES) of cells has been shown to induce a variety of responses, such as cytoskeleton rearrangements, migration, proliferation, and differentiation. In this study, we have investigated whether monophasic and biphasic pulsed ES could exert any effect on the proliferation and differentiation of huma...

journal_title：Stem cells and development

authors： Pietronave S,Zamperone A,Oltolina F,Colangelo D,Follenzi A,Novelli E,Diena M,Pavesi A,Consolo F,Fiore GB,Soncini M,Prat M

更新日期：2014-04-15 00:00:00

abstract：:Human embryonic stem cell (hESC)-derived natural killer (NK) cells are a promising source of antitumor lymphocytes for immunotherapeutics. They also provide a genetically tractable platform well suited for the study of antitumor immunotherapies in preclinical models. We have previously demonstrated the potency of hESC...

journal_title：Stem cells and development

authors： Knorr DA,Bock A,Brentjens RJ,Kaufman DS

更新日期：2013-07-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) self-renew indefinitely as highly organized pluripotent colonies. Unlike mouse pluripotent stem cell colonies, human colonies form a uniform, flat, epithelium-like monolayer. Interestingly, it has been reported that colony morphology is closely correlated with the maintenance of plur...

journal_title：Stem cells and development

authors： Kim JM,Moon SH,Park SJ,Lee HY,Hong KS,Seo J,Bae YS,Chung HM

更新日期：2013-01-15 00:00:00

abstract：:Traumatic spinal cord injury (SCI) leads to a cascade of secondary chemical insults, including oxidative stress and glutamate excitotoxicity, which damage host neurons and glia. Transplantation of exogenous neural stem/progenitor cells (NSPCs) has shown promise in enhancing regeneration after SCI, although survival of...

journal_title：Stem cells and development

authors： Hachem LD,Mothe AJ,Tator CH

更新日期：2016-08-15 00:00:00

abstract：:In the past few years research on stem cells has exploded as a tool to develop potential therapies to treat incurable neurodegenerative diseases. Stem cell transplantation has been effective in several animal models, but the underlying restorative mechanisms are still unknown. Several events such as cell fusion, neuro...

journal_title：Stem cells and development

authors： Cova L,Ratti A,Volta M,Fogh I,Cardin V,Corbo M,Silani V

更新日期：2004-02-01 00:00:00

abstract：:Remyelination is the goal of potential cell transplantation therapies for demyelinating diseases and other central nervous system injuries. Transplantation of oligodendrocyte precursor cells (OPCs) can result in remyelination in the central nervous system, and induced pluripotent stem cells (iPSCs) are envisioned to b...

journal_title：Stem cells and development

authors： Umebayashi D,Coles B,van der Kooy D

更新日期：2016-05-01 00:00:00

abstract：:Misexpression of the double homeodomain protein DUX4 in muscle is believed to cause facioscapulohumeral muscular dystrophy (FSHD). Although strategies are being devised to inhibit DUX4 activity in FSHD, there is little known about the normal function of this protein. Expression of DUX4 has been reported in pluripotent...

journal_title：Stem cells and development

authors： Dandapat A,Hartweck LM,Bosnakovski D,Kyba M

更新日期：2013-09-01 00:00:00

abstract：:Recent studies have focused on transcriptional regulation and gene expression profiling of human embryonic stem cells (hESCs). However, little information is available regarding the relationship between RNA expression and transcriptional regulation, which is critical in the complete understanding of pluripotency and d...

journal_title：Stem cells and development

authors： Player A,Wang Y,Bhattacharya B,Rao M,Puri RK,Kawasaki ES

更新日期：2006-06-01 00:00:00

abstract：:Esophagus and trachea arise from a common origin, the anterior foregut tube. The compartmentalization process of the foregut into the esophagus and trachea is still poorly understood. Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal congenital defects with an incidence r...

journal_title：Stem cells and development

authors： Raad S,David A,Que J,Faure C

更新日期：2020-08-01 00:00:00

abstract：:To be clinically relevant as a therapy for heart failure, endogenous progenitor cells must be isolated and expanded from aged and/or diseased tissue. Here, we investigated the effect of age and cardiac impairment resulting from lack of dystrophin on murine cardiosphere-derived cells (CDCs). CDCs were isolated and expa...

journal_title：Stem cells and development

authors： Hsiao LC,Perbellini F,Gomes RS,Tan JJ,Vieira S,Faggian G,Clarke K,Carr CA

更新日期：2014-05-01 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) are a promising tool for therapeutic applications in cell-based therapy and regenerative medicine, and MSCs from the human palatine tonsils have recently been used as a new tissue source. However, the understanding of the proliferation and differentiation capacity of tonsil-derived ...

journal_title：Stem cells and development

authors： Park GC,Song JS,Park HY,Shin SC,Jang JY,Lee JC,Wang SG,Lee BJ,Jung JS

更新日期：2016-08-01 00:00:00

abstract：:Liver transplantation is the only radical treatment for decompensated cirrhosis, but its use is limited owing to a shortage of donors; hence, there is an urgent need for new treatments. Previously, we developed a liver-regeneration therapy using autologous bone marrow-derived mesenchymal stem cells (BMSCs), which is u...

journal_title：Stem cells and development

authors： Nishi M,Matsumoto T,Fujisawa K,Suehiro Y,Takami T,Yamamoto N,Yamasaki T,Sakaida I

更新日期：2020-11-15 00:00:00

abstract：:On May 6th 2014, the European Court of Human Rights added yet a new element to the judicial history of stem cells as it ruled in Durisotto v. Italy [appeal n. 62804/13]. The ruling rejected a patient claim to access an unproven cell therapy-an outcome that is certainly to be welcomed. However, this ruling is a missed ...

journal_title：Stem cells and development

authors： Rial-Sebbag E,Blasimme A

更新日期：2014-12-01 00:00:00

abstract：:Bone marrow mesenchymal stem cells (MSCs) have shown potential to improve treatment of renal failure. The prohealing functions of MSCs have been found to be enhanced by treatment with the lipid mediator, 14S,21R-dihydroxy-docosa4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid (14S,21R-diHDHA). In this article, using a murine mode...

journal_title：Stem cells and development

authors： Tian H,Lu Y,Shah SP,Wang Q,Hong S

更新日期：2012-05-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) are multipotent stem cells with immunosuppressive and trophic support functions. While MSCs from different sources frequently display a similar appearance in culture, they often show differences in their surface marker and gene expression profiles. Although bone marrow is considered th...

journal_title：Stem cells and development

authors： Donders R,Bogie JFJ,Ravanidis S,Gervois P,Vanheusden M,Marée R,Schrynemackers M,Smeets HJM,Pinxteren J,Gijbels K,Walbers S,Mays RW,Deans R,Van Den Bosch L,Stinissen P,Lambrichts I,Gyselaers W,Hellings N

更新日期：2018-01-15 00:00:00

abstract：:In recent years it has been hypothesized that cancer stem cells (CSCs) are the actual driving force of tumor formation, highlighting the need to specifically target CSCs to successfully eradicate cancer growth and recurrence. Particularly, the deregulation of physiological signaling pathways controlling stem cell prol...

journal_title：Stem cells and development

authors： Persano L,Zagoura D,Louisse J,Pistollato F

更新日期：2015-10-15 00:00:00

abstract：:Individuals with neurodegenerative disorders or brain injury have few treatment options and it has been proposed that endogenous adult neural stem cells can be harnessed to repopulate dysfunctional nonneurogenic regions of the brain. We have accomplished this through the development of rationally designed hydrogel imp...

journal_title：Stem cells and development

authors： Clark AR,Carter AB,Hager LE,Price EM

更新日期：2016-08-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) exhibiting skewed X chromosome inactivation (XCI) have been reported. The copy number variations (CNVs), loss of heterozygosity (LOH), or single-nucleotide variant (SNV) events in those epigenetically distinct cells remain unknown, and whether such genetic abnormalities will influenc...

journal_title：Stem cells and development

authors： Liu WQ,Li JL,Wang J,He WY,Va L,Sheng XM,Wu BL,Sun XF

更新日期：2015-08-01 00:00:00

abstract：:Allergic asthma is an inflammatory airway disease caused by T helper type 2 (Th2)-driven immune responses. Recent studies have demonstrated that adipose-derived stromal cells (ASC) have an immunosuppressive effect on T-cell activity. This study was performed to investigate whether ASC can inhibit Th2-dependent allergi...

journal_title：Stem cells and development

authors： Park HK,Cho KS,Park HY,Shin DH,Kim YK,Jung JS,Park SK,Roh HJ

更新日期：2010-11-01 00:00:00

abstract：:In future, adipose-derived stem cells (ASC) might be used to treat neurological disorders. In this study, the neurotrophic and angiogenic properties of human ASC were evaluated, and their effects in a peripheral nerve injury model were determined. In vitro growth factor stimulation of the cells resulted in increased s...

journal_title：Stem cells and development

authors： Kingham PJ,Kolar MK,Novikova LN,Novikov LN,Wiberg M

更新日期：2014-04-01 00:00:00

abstract：:Halting the first clinical trial on the use of embryonic stem cell derivatives for spinal cord injury resulted in disappointment and created concerns about the future use of pluripotent stem cell-based therapy in the treatment of human diseases. This article presents reflections and concerns related to the halted embr...

journal_title：Stem cells and development

authors： Lukovic D,Stojkovic M,Moreno-Manzano V,Bhattacharya SS,Erceg S

更新日期：2014-01-01 00:00:00

abstract：:Non-tumorous liver tissue removed during surgery to resect hepatocellular carcinoma (HCC) is potentially a useful source of material from which cells, particularly liver progenitor/stem cells (LPCs), can be isolated to establish cell lines. The purpose of this study was to evaluate the applicability of the "plate-and-...

journal_title：Stem cells and development

authors： Zhang A,London R,Schulz FM,Giguère-Simmonds PW,Delriviere L,Chandraratana H,Hardy K,Zheng S,Olynyk JK,Yeoh G

更新日期：2010-08-01 00:00:00

abstract：:Recent evidence shows that amniotic fluid (AF) contains multiple cell types derived from the developing fetus, and may represent a novel source of stem cells for cell therapy. In this study, we examined the paracrine factors released by human amniotic fluid-derived mesenchymal stem cells (AF-MSCs) and their ability to...

journal_title：Stem cells and development

authors： Yoon BS,Moon JH,Jun EK,Kim J,Maeng I,Kim JS,Lee JH,Baik CS,Kim A,Cho KS,Lee JH,Lee HH,Whang KY,You S

更新日期：2010-06-01 00:00:00

abstract：:Tendons and ligaments (T/L) are dense connective tissues of mesodermal origin. During embryonic development, the tendon-specific cells descend from a sub-set of mesenchymal progenitors condensed in the syndetome, a dorsolateral domain of the sclerotome. These cells are defined by the expression of the transcription fa...

journal_title：Stem cells and development

authors： Alberton P,Popov C,Prägert M,Kohler J,Shukunami C,Schieker M,Docheva D

更新日期：2012-04-10 00:00:00

abstract：:Mesenchymal stems cells (MSCs) are a population of multipotent cells residing in several readily available adult tissue compartments, thus allowing for their ex vivo expansion. To date, therapeutic applications of MSCs have focused on their ability to hone to and support the repair of damaged tissues. More recent evid...

journal_title：Stem cells and development

authors： Reddy BY,Xu DS,Hantash BM

更新日期：2012-02-10 00:00:00

abstract：:Herein we review recent data that support host tolerance of allogeneic adult mesenchymal stem cells (MSC). Evidence is emerging that donor MSC deploy a very powerful array of mechanisms that allow escape from host allogeneic responses. These mechanisms include limited expression of alloantigen by the stem cell and cel...

journal_title：Stem cells and development

authors： Barry FP,Murphy JM,English K,Mahon BP

更新日期：2005-06-01 00:00:00

abstract：:Embryonic stem cells (ESCs) posses the ability to self-renew and differentiate into a multitude of lineages, including the osteogenic lineage in vitro. Currently, most approaches have focused on embryonic body (EB)-mediated osteogenic differentiation, which relies on formation of all three germ layers resulting in lim...

journal_title：Stem cells and development

authors： Hwang YS,Polak JM,Mantalaris A

更新日期：2008-10-01 00:00:00

abstract：:Collectively, lung diseases are one of the largest causes of premature death worldwide and represent a major focus in the field of regenerative medicine. Despite significant progress, only few stem cell platforms are currently available for cell-based therapy, disease modeling, and drug screening in the context of pul...

journal_title：Stem cells and development

authors： Hannan NR,Sampaziotis F,Segeritz CP,Hanley NA,Vallier L

更新日期：2015-07-15 00:00:00