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Safety and efficacy of a high-adhesion whitening strip under extended wear regimen.

Abstract：

OBJECTIVES:This randomized, parallel group, single centre clinical trial was conducted to evaluate the safety and compare the whitening efficacy for an extended wear of an experimental 9.5% H₂O₂ high-adhesion whitening strip, relative to a marketed 10% H₂O₂ control strip. METHODS:Twenty-nine eligible adult volunteers were randomly assigned to either a treatment series with an experimental 9.5% H₂O₂ high-adhesion whitening strip at home for 2h, once a day, for 8 days; or a marketed 10% H₂O₂ whitening strip for 30 min, on a similar daily regimen. Tooth color/whitening progression was recorded under standardized lighting conditions at baseline, day 3, day 5, and day 9, via digital imaging. Outcomes were reported using the CIELAB system. Usage safety was also assessed at each follow-up visit. Whitening efficacy for each group was investigated using a paired-difference t-test. The treatment groups were compared among each other using the analysis of covariance, with the baseline value and age as the covariates. RESULTS:Both treatment groups demonstrated statistically significant mean color improvement from baseline for b* (yellow ness) and L* (lightness) at each post-baseline visit. In addition, the 2-h high-adhesion strips demonstrated significantly greater improvement in b* and L* relative to the 30-min strip group at each follow-up visit. CONCLUSIONS:The 2-h regimen for the 9.5% H₂O₂ high-adhesion whitening strip was more efficient for tooth whitening than the 30-min regimen of 10% H₂O₂ whitening strip. Both treatments were well tolerated and the use of the test products during the study time frame was considered safe. CLINICAL RELEVANCE:Extending the daily wear time of whitening strips can improve the efficacy of the treatment and ultimately shorten the length of the treatment without any significant adverse effects.

journal_name

J Dent

journal_title

Journal of dentistry

authors

Oliveira GM,Miguez PA,Oliveira GB,Swift EJ Jr,Farrell S,Anastasia MK,Conde E,Walter R

doi

10.1016/j.jdent.2012.11.019

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

e46-52

eissn

0300-5712

issn

1879-176X

pii

S0300-5712(12)00321-1

journal_volume

41 Suppl 3

pub_type

杂志文章,随机对照试验

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Safety and efficacy of a high-adhesion whitening strip under extended wear regimen.