Abstract:
OBJECTIVE:Cytokine networks regulate innate and adaptive immune responses, which in turn are recognised to direct the progression or arrest of periodontal disease. This study aimed to compare the profile of seven cytokines, implicated in regulating T-cell networks, in gingival crevicular fluid (GCF) samples with differing classification of periodontal status. METHODS:GCF samples were collected from patients with strong clinical evidence for chronic periodontitis, aggressive periodontitis, gingivitis or no gingival inflammation. Cytokines IL-6, IFN-ɣ, IL-4, IL-2, IL-17 A, IL10 and TNFα were measured in each sample using a commercial cytometric bead array assay. Descriptive statistics were used to indicate central tendency, data scatter and analysis of variance for each cytokine concentrations between respective patient groups. Heat maps with dendrograms were produced to visualise hierarchical clustering and trends within the data. RESULTS:Median concentrations for all cytokines analysed were highest for gingivitis samples and lowest for aggressive periodontitis samples. The median concentration of IL-6 in gingivitis samples was observed to be 10.5 fold higher (˜17,300 pg/μl) than IL-6 in aggressive periodontitis samples (˜1600 pg/μl). Median concentrations of IL-10, IL-17 A and TNFα were also 2-2.2 fold higher in gingivitis samples compared to aggressive periodontitis. CONCLUSIONS:Descriptive statistical analysis noted raised concentrations of IL-6, IL-17 A and TNFα associated with gingivitis; pro-inflammatory cytokines usually associated with periodontal tissue destruction, including bone. Our results would suggest that these cytokines can additionally provide protective roles in preventing progression to advanced forms of periodontal disease. Potential for how these cytokines contribute to providing this role is discussed. CLINICAL SIGNIFICANCE:Defining the roles for the many cytokines involved in the pathogenesis of periodontal disease is far from complete. Consequently the results of this study serve to evidence proposals that cytokines can exhibit both pro- and anti-inflammatory effects, which is dependent on the signalling environment within which they exist and the antagonizing or modifying actions of other cytokines. Whilst future research is necessary to explore mechanistic action, our study contributes new knowledge suggesting that IL-6 and IL-17 A can provide roles in stabilising the lesion to limit disease progression, which does not preclude alternative roles in promoting periodontal bone loss in advanced forms of disease progression, which is also documented in the literature.
journal_name
J Dentjournal_title
Journal of dentistryauthors
Koshy B,Rees JS,Farnell DDJJ,Wei XQ,Waddington RJdoi
10.1016/j.jdent.2019.04.009subject
Has Abstractpub_date
2019-06-01 00:00:00pages
39-46eissn
0300-5712issn
1879-176Xpii
S0300-5712(19)30070-3journal_volume
85pub_type
杂志文章abstract:OBJECTIVES:Effective delivery of active agents to dental hard tissues is critical to product performance and pertinent to biofilm control, caries, erosion, hypersensitivity and tooth bleaching. The aim of this study was to investigate in vitro the bioadhesion and retention behaviour of non-aqueous delivery systems (NAD...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2010.06.005
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:The aim of this in vitro study was to evaluate the penetration of an infiltrant and a sealant, when applied as recommended, into fissure caries lesions. METHODS:The fissure systems of extracted human teeth were classified according to the international caries detection and assessment system (ICDAS, codes: 0...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2014.01.006
更新日期:2014-04-01 00:00:00
abstract:AIM:The aim of this study is to report the subsequent treatment provided, over the 11 years' data available, when a re-intervention was considered clinically necessary on a glass ionomer (GI) restoration. METHODS:A detailed sample of treatment records of patients has been established at the Dental Practice Division of...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2008.07.008
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:This study evaluated the inhibitory effect of proanthocyanidin (PA), a natural collagen cross-linker, on soluble and matrix-bound proteases, which are responsible for progressive degradation of exposed collagen fibrils within the hybrid layer and resin-dentine bond failure over time. METHODS:The inhibitory e...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2013.06.002
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:During laboratory fabrication procedures and/or clinical adjustments, pressable materials: IPS Empress and Empress 2, may be ground, polished or sandblasted. These treatments may affect their strength by introducing microscopic flaws and defects. This study investigates the effect of these procedures on the ...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2003.08.006
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To compare the effect of QMix (Dentsply Sirona), 7% maleic acid (MA), and 17% ethylenediaminetetraacetic acid (EDTA) on the microhardness, flexural strength and microstructure of mineral trioxide aggregate (MTA; ProRoot MTA, Dentsply Sirona). METHODS:Forty MTA specimens were divided into four groups: [I] QMi...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2017.08.018
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:The purpose of the current study was to examine whether alumina abrasion regime influenced the necessary surface roughness conducive to mechanical interlocking prior to composite resin bonding. The impact of alumina abrasion and cement lute on the bi-axial flexure strength and associated Weibull Moduli (m) o...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2003.08.004
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:The study evaluated the clinical performance and marginal adaptation of direct and semi-direct class II composite restorations in a split-mouth design over 3.5 years. DESIGN:44 upper posterior teeth in 11 adults with primary carious lesions were treated with 22 direct and 22 semi-direct restorations. Convent...
journal_title:Journal of dentistry
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jdent.2004.11.009
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To compare near infrared transillumination device, DIAGNOcam (DC) and bitewing radiography (BW) for the detection of proximal caries. MATERIALS AND METHODS:This retrospective analysis of DC and BW images of 18 students in dental medicine who had consented to the anonymous use of their dental record. The data...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2017.12.008
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:This study aimed to assess the effect of curing conditions--exposure time, mode, energy density, and exposure distance--on the mechanical properties of high-viscosity bulk-fill resin-based composites (RBCs) measured at simulated clinical relevant filling depths. METHODS:Three high-viscosity bulk-fill RBCs w...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2014.05.012
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVES:Demineralized lesions in tooth enamel around orthodontic brackets are caused by acids from cariogenic biofilm. This study aimed to develop a novel antibacterial orthodontic cement by incorporating a quaternary ammonium monomer dimethylaminododecyl methacrylate (DMADDM) into a commercial orthodontic cement, a...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2014.07.006
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:This prospective clinical study compared the performance of implant-retained (study group) and tooth-retained (control) zirconia based fixed dental prostheses (FDPs) with at least 4 units. The null-hypothesis stated that complication rates in both groups are equally distributed. METHODS:The study included p...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2014.10.011
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Newer tricalcium silicate cements (TSC) may offer biocompatibility with improved working properties. This study aimed to evaluate: (1) the occurrence of mineral deposition at the interface between dentine and two TSC (ProRoot(®) MTA and Biodentine(®)) in simulated body fluid, and (2) to investigate the natur...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2014.11.004
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:Verify the influence of curing methods on contraction stress, stress rate, and degree of conversion (DC) of a restorative composite and on bond strength of composite restoratives. METHODS:For the stress test, composite (0.84 mm thick) was applied between two 5-mm diameter glass rods, mounted in a servohydra...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2006.10.003
更新日期:2007-04-01 00:00:00
abstract::A significant correlation was found between the number of mutans streptococci in saliva and the proportional distribution of these microorganisms in pooled plaque from the margins of all restorations. At high salivary numbers there was a tendency towards a higher porportion of mutans streptococci in plaque from the ma...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/0300-5712(92)90130-5
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to investigate the effect of tooth age on colour adjustment potential of resin composite restorations in human teeth. METHODS:Twenty extracted human premolars with an A2 shade, extracted for orthodontic reasons from younger patients (20-28yrs) (younger teeth) and periodontal re...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2014.09.007
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:The effectiveness of fissure sealing in preventing dental caries in a subject-specific fashion was studied in order to forge a link between the controlled trials and knowledge creation in clinical practice. METHODS:The subjects were divided retrospectively into three categories according to the sealant trea...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2006.10.009
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:To investigate the effectiveness of an indicator gel in revealing exposed dentine. METHODS:Teeth prepared into dentine and then stained with the indicator gel were sectioned for histological examination. RESULTS:The indicator gel was found to stain dentine and thin layers of enamel. CONCLUSION:The gel is ...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/0300-5712(94)00010-d
更新日期:1995-12-01 00:00:00
abstract::The bacteriological contamination of pumice slurry in polishing units in a dental clinical area (high risk), a production laboratory (medium risk), and a non-clinical teaching laboratory (low risk), was investigated. Slurry samples taken from all three areas were found to be heavily contaminated with pathogenic organi...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/0300-5712(90)90030-i
更新日期:1990-10-01 00:00:00
abstract:OBJECTIVES:To measure the denaturation temperature (Td) of demineralised dentine matrix as a function of infiltration with water vs. polar solvents vs. adhesive resins. METHODS:Small discs of normal dentine were completely demineralised in 0.5M EDTA. Dried demineralised specimens were placed in water, methanol, ethano...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2007.10.003
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:this study aimed to synthesize AgNPs from green tea (GT) extract, forming GT-AgNPs, and to coat their surfaces with silica, resulting in light-colored Ag@SiO2 nanoparticles. MATERIALS AND METHODS:particles were characterized and tested for minimal inhibitory concentration (MIC), biofilm formation against St...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2020.103327
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:This randomized controlled trial compared the survival of glass fibre and cast metal dental posts used to restore endodontically treated teeth with no remaining coronal wall. METHODS:Fifty-four participants (45 women) and 72 teeth were evaluated during a follow-up period of up to 3 years. Teeth were randomly...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2014.02.003
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:Test the ability of acidic fluoridated solutions to enhance fluoride (F) bound on bacteria (1) and the effect of dentifrice consistency on plaque fluid F uptake (2). METHODS:(1) Streptococcus mutans isolates were grown in BHI medium (37°C/18h). Bacteria were washed either with EDTA or CaCl2 both at 1mM to re...
journal_title:Journal of dentistry
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jdent.2014.12.003
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the influence of different titanium zirconium (TiZr) alloy surfaces on primary human gingival fibroblasts (HGF) for improved soft tissue integration of dental implants. METHODS:TiZr polished, machined and machined+HCl/H2SO4 acid-etched surfaces were modified by cathodic...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2013.11.003
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:The in-vitro dissolution of bioactive glass-based toothpastes and their capacity to form apatite-like phases in buffer solutions have been investigated. MATERIALS AND METHODS:The commercial toothpaste samples were tested on immersion in artificial saliva, Earle's salt solution and Tris buffer for duration f...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2017.10.015
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:Evaluate color and translucency of both non-colored and colored zirconia ceramics and compare them with corresponding properties of human dentine. METHODS:0.5mm thick samples of human (MSHD) and bovine (MSBD) dentine were obtained from 5 extracted human anterior maxillary teeth and 5 bovine incisors, respec...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2012.08.018
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to evaluate the induced changes in the chemical and mechanical performance at the glass-ionomer cement-dentin interface after mechanical load application. METHODS:A conventional glass-ionomer cement (GIC) (Ketac Bond), and a resin-modified glass-ionomer cement (RMGIC) (Vitrebond Plu...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2018.04.006
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:To conduct a systematic review and meta-analysis to explore the association between erosive toothwear and gastro-oesophageal reflux disease or symptoms (GERD/S). SOURCES:Electronic searches were performed in Scopus, Embase, and Web of Science databases for the identification of relevant studies, from 1980 u...
journal_title:Journal of dentistry
pub_type: 杂志文章,meta分析
doi:10.1016/j.jdent.2020.103284
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine enamel and dentin bond durability after long-term water storage using self-etch adhesives. METHODS:Two single step self-etch adhesives (SU, Scotchbond Universal and GB, G-ӕnial Bond) and a two-step self-etch adhesive (OX, OptiBond XTR) were used. The shear bond str...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2015.10.018
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the kinetics of protein interactions with a novel hydroxyapatite-polylactide (HA-PLA) composite membrane material. METHODS:Trilayer PLA and HA-PLA composite membranes reinforced with PLA fibres were used to absorb and release protein which was measured by a BioRad as...
journal_title:Journal of dentistry
pub_type: 杂志文章
doi:10.1016/j.jdent.2009.06.014
更新日期:2009-11-01 00:00:00