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Goblet cell carcinoid neoplasm of the appendix: clinical and CT features.

Abstract：

PURPOSE:To describe the clinical and CT imaging features of goblet cell carcinoid (GCC) neoplasm of the appendix. METHODS AND MATERIALS:A computer search of pathology and radiology records over a 19-year period at our two institutions was performed using the search string "goblet". In the patients with appendiceal GCC neoplasms who had abdominopelvic CT, imaging findings were categorized, blinded to gross and surgical description, as: "Appendicitis", "Prominent appendix without peri-appendiceal infiltration", "Mass" or "Normal appendix". The CT appearance was correlated with an accepted pathological classification of: low grade GCC, signet ring cell adenocarcinoma ex, and poorly differentiated adenocarcinoma ex GCC group. RESULTS:Twenty-seven patients (age range, 28-80 years; mean age, 52 years; 15 female, 12 male) with pathology-proven appendiceal GCC neoplasm had CT scans that were reviewed. Patients presented with acute appendicitis (n=12), abdominal pain not typical for appendicitis (n=14) and incidental finding (n=1). CT imaging showed 9 Appendicitis, 9 Prominent appendices without peri-appendiceal infiltration, 7 Masses and 2 Normal appendices. Appendicitis (8/9) usually correlated with typical low grade GCC on pathology. In contrast, the majority of Masses and Prominent Appendices without peri-appendiceal infiltration were pathologically confirmed to be signet ring cell adenocarcinoma ex GCC. Poorly differentiated adenocarcinoma ex GCC was seen in only a small minority of patients. Hyperattenuation of the appendiceal neoplasm was seen in a majority of cases. CONCLUSIONS:GCC neoplasm of the appendix should be considered in the differential diagnosis in patients with primary appendiceal malignancy. Our cases demonstrated close correlation between our predefined CT pattern and the pathological classification.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Lee KS,Tang LH,Shia J,Paty PB,Weiser MR,Guillem JG,Temple LK,Nash GM,Reidy D,Saltz L,Gollub MJ

doi

10.1016/j.ejrad.2012.05.038

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

85-9

issue

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(12)00465-2

journal_volume

pub_type

杂志文章,多中心研究

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Goblet cell carcinoid neoplasm of the appendix: clinical and CT features.