Abstract:
BACKGROUND:Graft-versus-host disease (GvHD) is the most important complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) responsible for increased mortality. Recent studies have discussed the use of oral GvHD screening tests in the diagnosis of systemic GvHD. This is the first study of the significance of oral labial biopsy in diagnosis of hepatic graft-versus-host disease (H-GvHD) following allo-HSCT. MATERIAL/METHODS:Twenty-one patients after alloHSCT were selected: 12 patients with H-GvHD established clinically and in laboratory tests, and 9 patients without features of GvHD (control group). Histopathological and immunohistochemical evaluations of tissue samples included the following: 15 samples of oral mucosa (OM), 19 of lip salivary glands (LSG), and 5 of the liver, were performed in both groups. RESULTS:All patients had clinically normal oral mucosa and 4 patients with H-GvHD manifested with xerostomia symptoms. Histological examination of LSG and/or OM confirmed the GvHD diagnosis in 9 of 12 patients with H-GvHD. The microscopic changes included: mild inflammatory lymphocytic infiltrates and apoptotic bodies in OM, and inflammatory infiltrates of mild degree with minimal CD8+ T cells predominance in the invaded ducts epithelium in LSG. In the control group, 4 of 9 patients had mild chronic inflammation, which did not fulfill the criteria of GvHD. The histopathological image of liver biopsies correlated with the clinical GvHD diagnosis. CONCLUSIONS:The microscopic evaluation of LSG and/or OM biopsy confirms the clinical diagnosis of H-GvHD, regardless of the absence of clinical oral symptoms of GVHD. The histopathological features of oral GvHD may be subtle; the diagnosis requires a clinico-pathological and laboratory approach to exclude the other diseases with similar histopathological features.
journal_name
Ann Transplantjournal_title
Annals of transplantationauthors
Prochorec-Sobieszek M,Nasiłowska-Adamska B,Szumera-Ciećkiewicz A,Tomaszewska A,Hałaburda K,Szczepiński A,Szymańska-Giemza O,Ziarkiewicz-Wróblewska B,Mariańska Bdoi
10.12659/aot.883462subject
Has Abstractpub_date
2012-07-01 00:00:00pages
85-92issue
3eissn
1425-9524issn
2329-0358pii
883462journal_volume
17pub_type
杂志文章abstract:BACKGROUND:Colonic diverticular disease is rare in developing nations but common in Western and industrialized societies. Many studies show that heart and lung transplantation increase the risk of having severe diverticulitis, although the exact magnitude of this risk remain unclear because many of these studies have b...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2010-07-01 00:00:00
abstract::Liver graft function after transplantation is dependent on ischemia-reperfusion injury, toxicity of drugs (immunosuppression, antibiotics and other) and transplant rejection. Although routinely monitored with enzymatic tests (AST, ALT, GGT, ALP), bilirubin and coagulation parameters, differentiation between these path...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::BACKGROUND Prospective evidence is lacking regarding the association between renal dysfunction and cardiovascular events after liver transplantation. MATERIAL AND METHODS Data were analyzed post hoc regarding renal function and major adverse cardiac events in a two-year prospective trial of de novo liver transplant re...
journal_title:Annals of transplantation
pub_type: 杂志文章,随机对照试验
doi:10.12659/AOT.911030
更新日期:2018-10-26 00:00:00
abstract:BACKGROUND:Animal models to investigate pathophysiology and xenotransplantation require complex techniques and significant animal utilization. The aim of the study was to develop a reliable ex-vivo technique to test xenotransplant interventions. MATERIAL/METHODS:Miniature Swine being utilized for a nonsurvival study a...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The number of transplant surgeries across the globe has markedly increased in recent decades and is associated with improvement in outcomes. Factors that could improve the organization of post-transplant care are sought. The aim of our study was to evaluate the changes in post-transplant care in the largest ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.895981
更新日期:2016-04-05 00:00:00
abstract::BACKGROUND Chronic allograft nephropathy (CAN) remains a major problem for long-term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4) is significantly upregulated following renal injury and fibrotic response. We investigated the effect of AMD3100, a CXCR4 antagonis...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.899492
更新日期:2016-11-25 00:00:00
abstract::The hepatitis B virus (HBV) infects more than 260 million people globally, with increasing incidence, especially in developing countries. Despite antiviral therapies, HBV-related end-stage liver disease remains one of the most important indications for liver transplantation worldwide. Although new available treatments...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:10.12659/aot.900216
更新日期:2016-10-14 00:00:00
abstract:BACKGROUND:Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.883452
更新日期:2012-07-01 00:00:00
abstract::BACKGROUND The incidence of surgical complications after kidney transplantation ranges from 10-25%. The purpose of this study was to evaluate if the application of fibrin glue as a preventive agent reduces surgical morbidity after a living-related-donor kidney transplantation. MATERIAL AND METHODS A controlled clinica...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.899821
更新日期:2016-09-20 00:00:00
abstract:BACKGROUND:Anti-CMV prophylaxis is currently a routine management in patients after organ transplantation. One of the clinical symptoms of CMV infection may be lesions in the oral cavity.The aim of this study was to determine the relationship between CMV infection, occurrence of Candida species and presence of oral muc...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Sirolimus is a potent immunosuppressive drug that has been shown to decrease the incidence of rejection post renal transplantation. Dyslipidemia is a well recognized side effect of sirolimus therapy, which may have an impact on patient survival and post-transplant cardiac morbidity and mortality. It is unkno...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
abstract::BACKGROUND Intrahepatic cholangiocarcinoma (ICC) can be incidentally diagnosed after liver transplantation (LT). We investigated the clinicopathological features of LT recipients with ICC and compared prognosis with that of the control group. MATERIAL AND METHODS We identified 16 recipients with ICC in our institution...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.901504
更新日期:2017-01-26 00:00:00
abstract:BACKGROUND:Data in kidney transplant recipients regarding elimination of calcineurin inhibitor (CNI) therapy from a de novo regimen based on low CNI exposure and an mTOR inhibitor are sparse, and restricted to CNI elimination within the first six months post-transplant. MATERIAL/METHODS:In a 12-month, randomized, mult...
journal_title:Annals of transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.12659/aot.882637
更新日期:2012-01-01 00:00:00
abstract::Solid organ transplantation program in Poland is very limited. The main reason of this is organ shortage. All the organs procured are transplanted. It is a general feeling that recently issued legal regulations will favorably influence organ donation, however the improvement may be expected within a few years and will...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::Calcium plays a crucial role in physiological process in liver cells however in high concentrations these ions can be pathogenic and lead to cell death. Mechanisms responsible for maintaining calcium ion concentration gradient in physiological conditions include transmembrane transport, storage in intracellular organe...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The calcineurin inhibitor (CNI) tacrolimus (Tac) is an effective immunosuppressant used after liver transplantation (LTx), but is often associated with CNI nephrotoxicity. Currently, there is no simple clinical predictor for CNI nephrotoxicity after LTx. We hypothesized that the Tac metabolism rate - defined...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.895898
更新日期:2016-03-22 00:00:00
abstract::BACKGROUND Dual kidney transplantation (DKT) of expanded-criteria donors is a cost-intensive procedure that aims to increase the pool of available deceased organ donors and has demonstrated equivalent outcomes to expanded-criteria single kidney transplantation (eSKT). The objective of this study was to develop an allo...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.898328
更新日期:2016-09-08 00:00:00
abstract::HIV infection has been traditionally considered to be an absolute contraindication for solid organ transplantation. Recent advances in HIV treatment, as highly active antiretroviral therapy (HAART), significantly reduced HIV-related mortality and morbidity. At the same time the number of HIV-infected patients with end...
journal_title:Annals of transplantation
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Bone marrow mesenchymal stem cells (BMSC) are common seed cells for transplantation. However, there are some limitations in their use that have not yet been resolved. Our research modified tumor-related genes temporarily on BMSC which simulated tumorigenesis temporarily in vitro. The cells were named tempora...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.881995
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES AND METHODS:Brain death related hemodynamic instability and/or cardiac dysfunction is frequently described in the potential organ donor which may lead to exclusion of the heart from transplantation. The underlying mechanisms are controversely discussed. Therefore, in the present study, potential brain death ...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::Successful kidney transplantation (KT) improves significantly the quality of life as compared with hemodialysis. Vocational rehabilitation and professional activity are the vital part of general rehabilitation and play an important role in determining the quality of life. The aim of this study was to evaluate the degr...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::BACKGROUND Numerically, nurses represent the largest healthcare profession, thus setting norms for the quality and safety of direct patient care. Evidence of a global shortage of nurses in all clinical practice settings across different healthcare systems and countries has been documented. The aims of the present stud...
journal_title:Annals of transplantation
pub_type: 杂志文章,多中心研究
doi:10.12659/aot.898305
更新日期:2016-09-01 00:00:00
abstract::Aim of this monocentric study is to compare the outcome of 101 renal transplants performed in patients older than 55 years with single kidney retrieved from donors older than 50 years, with 263 transplants performed in patients younger than 55 years transplanted with young kidneys. Delayed graft function (DGF) had sim...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Metabolic abnormalities have been reported in patients undergoing hematopoietic stem cell transplantation (HSCT). Potential causes, risk factors and outcomes of electrolyte imbalances have thoroughly been investigated. On HSCT recipients, multiple pathophysiologic contributors are inflicting electrolyte abno...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:Aim of the study was to assess frequency and risk factors of steroid resistant cellular rejection (SRR) in heart transplant recipients, to determine methods of its treatment, and to evaluate influence of steroid resistant rejection and method of its treatment on short- and long-term results. METHODS:All pts...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Early initiation of enteral nutrition is recommended after some surgical procedures. This study retrospectively analyzed the effects of addition of early enteral nutrition (EEN) support during the postoperative phase in patients after living-donor liver transplantation (LDLT). MATERIAL AND METHODS:The subje...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/AOT.893421
更新日期:2015-06-25 00:00:00
abstract:OBJECTIVES:The goal of this study was to examine the impact of various immunosuppressive regimens on an early NK cell recovery following haematopoietic cell transplantation (alloHCT). METHODS:The number of peripheral blood NK cells was analysed with the use of flow cytometry on day +30 (+/-2) after alloHCT from an HLA...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Transplantation is the only effective method of treatment for end-stage and acute liver failure. Increased average survival time has been observed, and results from improved surgical technique and amended immunosuppression protocols. However, longer survival of patients after orthotopic liver transplantation...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.882005
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:The aim of this study was to analyze the use of fixed-wing air ambulance (FWAA) services in Poland during the period 2012-2013, with particular emphasis on air transport of organ recipients to transplantation centers. MATERIAL AND METHODS:This was a retrospective, cross-sectional analysis of data derived fr...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:10.12659/aot.895321
更新日期:2015-10-20 00:00:00
abstract:BACKGROUND:Xenotransplantation from pig to humans may be associated with the risk of transmission of porcine endogenous retroviruses (PERVs) that are present in the genome of all pigs and that infect human cells in vitro. However, it remains unclear whether PERVs infect transplant recipients in vivo and, if so, whether...
journal_title:Annals of transplantation
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00