Diversity and evolution of multiple orc/cdc6-adjacent replication origins in haloarchaea.

abstract：BACKGROUND:Oxidative stress is a consequence of normal and abnormal cellular metabolism and is linked to the development of human diseases. The effective functioning of the pathway responding to oxidative stress protects the cellular DNA against oxidative damage; conversely the failure of the oxidative stress response ...

journal_title：BMC genomics

authors： Sridharan S,Layek R,Datta A,Venkatraj J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:G protein-coupled receptors (GPCRs) are major players in cell communication, regulate a whole range of physiological functions during development and throughout adult life, are affected in numerous pathological situations, and constitute so far the largest class of drugable targets for human diseases. The co...

journal_title：BMC genomics

authors： Maurel B,Le Digarcher A,Dantec C,Journot L

更新日期：2011-05-16 00:00:00

abstract：BACKGROUND:Fusarium head blight (FHB), caused mainly by Fusarium graminearum (Fg) Schwabe (teleomorph: Gibberellazeae Schwble), brings serious damage to wheat production. Chinese wheat landrace Wangshuibai is one of the most important resistance sources in the world. The knowledge of mechanism underlying its resistance...

journal_title：BMC genomics

authors： Xiao J,Jin X,Jia X,Wang H,Cao A,Zhao W,Pei H,Xue Z,He L,Chen Q,Wang X

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:Microsatellites are widely used for many genetic studies. In contrast to single nucleotide polymorphism (SNP) and genotyping-by-sequencing methods, they are readily typed in samples of low DNA quality/concentration (e.g. museum/non-invasive samples), and enable the quick, cheap identification of species, hyb...

journal_title：BMC genomics

authors： Dawson DA,Ball AD,Spurgin LG,Martín-Gálvez D,Stewart IR,Horsburgh GJ,Potter J,Molina-Morales M,Bicknell AW,Preston SA,Ekblom R,Slate J,Burke T

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:The hepatitis E virus (HEV) is the causative pathogen of hepatitis E, a global public health concern. HEV comprises 8 genotypes with a wide host range and geographic distribution. This study aims to determine the genetic factors influencing the molecular adaptive changes of HEV open reading frames (ORFs) and...

journal_title：BMC genomics

authors： Baha S,Behloul N,Liu Z,Wei W,Shi R,Meng J

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Genomic inversion is one type of structural variations (SVs) and is known to play an important biological role. An established problem in sequence data analysis is calling inversions from high-throughput sequence data. It is more difficult to detect inversions because they are surrounded by duplication or ot...

journal_title：BMC genomics

authors： Wu Z,Wu Y,Gao J

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth. Nevertheless, MZ twins are sometimes discordant for common complex diseases. The goal of this study is to identify genomic and epig...

journal_title：BMC genomics

authors： Lyu G,Zhang C,Ling T,Liu R,Zong L,Guan Y,Huang X,Sun L,Zhang L,Li C,Nie Y,Tao W

更新日期：2018-06-04 00:00:00

abstract：BACKGROUND:With the advance of new massively parallel genotyping technologies, quantitative trait loci (QTL) fine mapping and map-based cloning become more achievable in identifying genes for important and complex traits. Development of high-density genetic markers in the QTL regions of specific mapping populations is ...

journal_title：BMC genomics

authors： Wu X,Ren C,Joshi T,Vuong T,Xu D,Nguyen HT

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:Despite substantial progress in mosquito genomic and genetic research, few cis-regulatory elements (CREs), DNA sequences that control gene expression, have been identified in mosquitoes or other non-model insects. Formaldehyde-assisted isolation of regulatory elements paired with DNA sequencing, FAIRE-seq, i...

journal_title：BMC genomics

authors： Behura SK,Sarro J,Li P,Mysore K,Severson DW,Emrich SJ,Duman-Scheel M

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a large family of endogenous, non-coding RNAs, about 22 nucleotides long, which regulate gene expression through sequence-specific base pairing with target mRNAs. Extensive studies have shown that miRNA expression in the skin changes remarkably during distinct stages of the hair cycle ...

journal_title：BMC genomics

authors： Yuan C,Wang X,Geng R,He X,Qu L,Chen Y

更新日期：2013-07-28 00:00:00

abstract：BACKGROUND:The use of RNAseq to resolve the transcriptional organization of an organism was established in recent years and also showed the complexity and dynamics of bacterial transcriptomes. The aim of this study was to comprehensively investigate the transcriptome of the industrially relevant amino acid producer and...

journal_title：BMC genomics

authors： Pfeifer-Sancar K,Mentz A,Rückert C,Kalinowski J

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:The accurate determination of the genomic coordinates for a given gene - its gene model - is of vital importance to the utility of its annotation, and the accuracy of bioinformatic analyses derived from it. Currently-available methods of computational gene prediction, while on the whole successful, frequentl...

journal_title：BMC genomics

authors： Dunne MP,Kelly S

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:The MYB gene family comprises one of the richest groups of transcription factors in plants. Plant MYB proteins are characterized by a highly conserved MYB DNA-binding domain. MYB proteins are classified into four major groups namely, 1R-MYB, 2R-MYB, 3R-MYB and 4R-MYB based on the number and position of MYB r...

journal_title：BMC genomics

authors： Katiyar A,Smita S,Lenka SK,Rajwanshi R,Chinnusamy V,Bansal KC

更新日期：2012-10-10 00:00:00

abstract：BACKGROUND:Obtaining reliable and reproducible two-color microarray gene expression data is critically important for understanding the biological significance of perturbations made on a cellular system. Microarray design, RNA preparation and labeling, hybridization conditions and data acquisition and analysis are varia...

journal_title：BMC genomics

authors： Novoradovskaya N,Whitfield ML,Basehore LS,Novoradovsky A,Pesich R,Usary J,Karaca M,Wong WK,Aprelikova O,Fero M,Perou CM,Botstein D,Braman J

更新日期：2004-03-09 00:00:00

abstract：BACKGROUND:Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges can provide insights into adaptive radiations. Caecili...

journal_title：BMC genomics

authors： Torres-Sánchez M,Gower DJ,Alvarez-Ponce D,Creevey CJ,Wilkinson M,San Mauro D

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Tandem mass spectrometry (MS/MS) has become a standard method for identification of proteins extracted from biological samples but the huge number and the noise contamination of MS/MS spectra obstruct swift and reliable computer-aided interpretation. Typically, a minor fraction of the spectra per sample (mos...

journal_title：BMC genomics

authors： Mujezinovic N,Schneider G,Wildpaner M,Mechtler K,Eisenhaber F

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) are a new class of regulatory molecules with roles in diverse biological processes. While much effort has been invested in the analysis of lncRNAs from established plant models Arabidopsis, maize, and rice, almost nothing is known about lncRNAs from fruit crops, including those...

journal_title：BMC genomics

authors： Kang C,Liu Z

更新日期：2015-10-19 00:00:00

abstract：BACKGROUND:The relationships between parasitoids and their insect hosts have attracted attention at two levels. First, the basic biology of host-parasitoid interactions is of fundamental interest. Second, parasitoids are widely used as biological control agents in sustainable agricultural programs. Females of the grega...

journal_title：BMC genomics

authors： Fang Q,Wang L,Zhu J,Li Y,Song Q,Stanley DW,Akhtar ZR,Ye G

更新日期：2010-09-02 00:00:00

abstract：BACKGROUND:Several in vitro studies document the function of the transcriptional regulator TrmBL1 of Pyrococcus furiosus. These data indicate that the protein can act as repressor or activator and is mainly involved in transcriptional control of sugar uptake and in the switch between glycolysis and gluconeogenesis. The...

journal_title：BMC genomics

authors： Reichelt R,Gindner A,Thomm M,Hausner W

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Dinoflagellates are unicellular marine and freshwater eukaryotes. They possess large nuclear genomes (1.5-245 gigabases) and produce structurally unique and biologically active polyketide secondary metabolites. Although polyketide biosynthesis is well studied in terrestrial and freshwater organisms, only rec...

journal_title：BMC genomics

authors： Beedessee G,Hisata K,Roy MC,Satoh N,Shoguchi E

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Although profiling of RNA in single cells has broadened our understanding of development, cancer biology and mechanisms of disease dissemination, it requires the development of reliable and flexible methods. Here we demonstrate that the EpiStem RNA-Amp™ methodology reproducibly generates microgram amounts of...

journal_title：BMC genomics

authors： Rothwell DG,Li Y,Ayub M,Tate C,Newton G,Hey Y,Carter L,Faulkner S,Moro M,Pepper S,Miller C,Blackhall F,Bertolini G,Roz L,Dive C,Brady G

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Fusion genes are known to be drivers of many common cancers, so they are potential markers for diagnosis, prognosis or therapy response. The advent of paired-end RNA sequencing enhances our ability to discover fusion genes. While there are available methods, routine analyses of large number of samples are st...

journal_title：BMC genomics

authors： Vu TN,Deng W,Trac QT,Calza S,Hwang W,Pawitan Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:The siRNA and piRNA pathways have been shown in insects to be essential for regulation of gene expression and defence against exogenous and endogenous genetic elements (viruses and transposable elements). The vast majority of endogenous small RNAs produced by the siRNA and piRNA pathways originate from repet...

journal_title：BMC genomics

authors： Biryukova I,Ye T

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:Gaucher disease is caused by defective glucocerebrosidase activity and the consequent accumulation of glucosylceramide. The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure. RESULTS:To elucidate this pathogenic pathway, de...

journal_title：BMC genomics

authors： Xu YH,Jia L,Quinn B,Zamzow M,Stringer K,Aronow B,Sun Y,Zhang W,Setchell KD,Grabowski GA

更新日期：2011-01-11 00:00:00

abstract：BACKGROUND:The ability to identify regions of the genome inherited with a dominant trait in one or more families has become increasingly valuable with the wide availability of high throughput sequencing technology. While a number of methods exist for mapping of homozygous variants segregating with recessive traits in c...

journal_title：BMC genomics

authors： Levine AP,Connor TM,Oygar DD,Neild GH,Segal AW,Maxwell PH,Gale DP

更新日期：2015-03-10 00:00:00

abstract：MOTIVATION:With the rapid growth rate of newly sequenced genomes, species tree inference from multiple genes has become a basic bioinformatics task in comparative and evolutionary biology. However, accurate species tree estimation is difficult in the presence of gene tree discordance, which is often due to incomplete l...

journal_title：BMC genomics

authors： Bayzid MS,Hunt T,Warnow T

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Two-component systems (TCS) play critical roles in sensing and responding to environmental cues. Azospirillum is a plant growth-promoting rhizobacterium living in the rhizosphere of many important crops. Despite numerous studies about its plant beneficial properties, little is known about how the bacterium s...

journal_title：BMC genomics

authors： Borland S,Oudart A,Prigent-Combaret C,Brochier-Armanet C,Wisniewski-Dyé F

更新日期：2015-10-22 00:00:00

abstract：BACKGROUND:The pituitary is a critical neuroendocrine gland that is comprised of five hormone-secreting cell types, which develops in tandem during the embryonic stage. Some essential genes have been identified in the early stage of adenohypophysial development, such as PITX1, FGF8, BMP4 and SF-1. However, it is likely...

journal_title：BMC genomics

authors： Ma Y,Qi X,Du J,Song S,Feng D,Qi J,Zhu Z,Zhang X,Xiao H,Han Z,Hao X

更新日期：2009-03-15 00:00:00

abstract：BACKGROUND:Matricaria recutita (German chamomile) and Chamaemelum nobile (Roman chamomile) belong to the botanical family Asteraceae. These two herbs are not only morphologically distinguishable, but their secondary metabolites - especially the essential oils present in flowers are also different, especially the terpen...

journal_title：BMC genomics

authors： Tai Y,Hou X,Liu C,Sun J,Guo C,Su L,Jiang W,Ling C,Wang C,Wang H,Pan G,Si X,Yuan Y

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Although prokaryotic gene transcription has been studied over decades, many aspects of the process remain poorly understood. Particularly, recent studies have revealed that transcriptomes in many prokaryotes are far more complex than previously thought. Genes in an operon are often alternatively and dynamica...

journal_title：BMC genomics

authors： Li S,Dong X,Su Z

更新日期：2013-07-30 00:00:00