Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.

abstract：BACKGROUND:Dermatophytes are the primary causative agent of dermatophytoses, a disease that affects billions of individuals worldwide. Trichophyton rubrum is the most common of the superficial fungi. Although T. rubrum is a recognized pathogen for humans, little is known about how its transcriptional pattern is related...

journal_title：BMC genomics

authors： Wang L,Ma L,Leng W,Liu T,Yu L,Yang J,Yang L,Zhang W,Zhang Q,Dong J,Xue Y,Zhu Y,Xu X,Wan Z,Ding G,Yu F,Tu K,Li Y,Li R,Shen Y,Jin Q

更新日期：2006-10-11 00:00:00

abstract：BACKGROUND:Flow cytometry has been widely used for the diagnosis of various hematopoietic diseases. Although there have been advances in the number of biomarkers that can be analyzed simultaneously and technologies that enable fast performance, the diagnostic data are still interpreted by a manual gating strategy. The ...

journal_title：BMC genomics

authors： Shih MC,Huang SH,Donohue R,Chang CC,Zu Y

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The genome-wide association (GWA) approach represents an alternative to biparental linkage mapping for determining the genetic basis of trait variation. Both approaches rely on recombination to re-arrange the genome, and seek to establish correlations between phenotype and genotype. The major advantages of G...

journal_title：BMC genomics

authors： Cericola F,Portis E,Lanteri S,Toppino L,Barchi L,Acciarri N,Pulcini L,Sala T,Rotino GL

更新日期：2014-10-14 00:00:00

abstract：BACKGROUND:The contribution of genetic factors to the development of breast cancer in the admixed and consanguineous population of the western region of Saudi Arabia is thought to be significant as the disease is early onset. The current protocols of continuous clinical follow-up of relatives of such patients are costl...

journal_title：BMC genomics

authors： Merdad A,Gari MA,Hussein S,Al-Khayat S,Tashkandi H,Al-Maghrabi J,Al-Thubaiti F,Hussein IR,Koumosani T,Shaer N,Chaudhary AG,Abuzenadah AM,Al-Qahtani MH,Dallol A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:High throughput molecular sequencing and increased biospecimen variety have introduced significant informatics challenges for research biorepository infrastructures. We applied a modular system integration approach to develop an operational biorepository management system. This method enables aggregation of ...

journal_title：BMC genomics

authors： Felmeister AS,Masino AJ,Rivera TJ,Resnick AC,Pennington JW

更新日期：2016-08-18 00:00:00

abstract：BACKGROUND:The antitumor drug daunorubicin exerts some of its cytotoxic effects by binding to DNA and inhibiting the transcription of different genes. We analysed this effect in vivo at the transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal (IC40) concentrations of the drug to...

journal_title：BMC genomics

authors： Rojas M,Casado M,Portugal J,Piña B

更新日期：2008-07-30 00:00:00

abstract：BACKGROUND:Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. Therefore, the genetic admixture may cause biased genetic association study with cancer susceptibility variants specificall...

journal_title：BMC genomics

authors： Wang LJ,Zhang CW,Su SC,Chen HH,Chiu YC,Lai Z,Bouamar H,Ramirez AG,Cigarroa FG,Sun LZ,Chen Y

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:DNA microarrays provide the ability to interrogate multiple genes in a single experiment and have revolutionized genomic research. However, the microarray technology suffers from various forms of biases and relatively low reproducibility. A particular source of false data has been described, in which non-ran...

journal_title：BMC genomics

authors： Koren A,Tirosh I,Barkai N

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:The use of RNAseq to resolve the transcriptional organization of an organism was established in recent years and also showed the complexity and dynamics of bacterial transcriptomes. The aim of this study was to comprehensively investigate the transcriptome of the industrially relevant amino acid producer and...

journal_title：BMC genomics

authors： Pfeifer-Sancar K,Mentz A,Rückert C,Kalinowski J

更新日期：2013-12-17 00:00:00

abstract：BACKGROUND:Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyze...

journal_title：BMC genomics

authors： Sudhakar P,Reck M,Wang W,He FQ,Wagner-Döbler I,Zeng AP

更新日期：2014-05-12 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of synovial joints. RA affects up to 1 % of the population worldwide. Currently, there are no drugs that can cure RA or achieve sustained remission. The unknown cause of the disease represents a significan...

journal_title：BMC genomics

authors： Xu R,Wang Q

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:A variety of species and experimental designs have been used to study genetic influences on alcohol dependence, ethanol response, and related traits. Integration of these heterogeneous data can be used to produce a ranked target gene list for additional investigation. RESULTS:In this study, we performed a u...

journal_title：BMC genomics

authors： Zhao Z,Guo AY,van den Oord EJ,Aliev F,Jia P,Edenberg HJ,Riley BP,Dick DM,Bettinger JC,Davies AG,Grotewiel MS,Schuckit MA,Agrawal A,Kramer J,Nurnberger JI Jr,Kendler KS,Webb BT,Miles MF

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Various saprotrophic microorganisms, especially filamentous fungi, can efficiently degrade lignocellulose that is one of the most abundant natural materials on earth. It consists of complex carbohydrates and aromatic polymers found in the plant cell wall and thus in plant debris. Aspergillus fumigatus Z5 was...

journal_title：BMC genomics

authors： Miao Y,Liu D,Li G,Li P,Xu Y,Shen Q,Zhang R

更新日期：2015-06-16 00:00:00

abstract：BACKGROUND:Variation in gene expression between two Drosophila melanogaster strains, as revealed by transcriptional profiling, seldom corresponded to variation in proximal promoter sequence for 34 genes analyzed. Two sets of protein-coding genes were selected from pre-existing microarray data: (1) those whose expressio...

journal_title：BMC genomics

authors： Brown RP,Feder ME

更新日期：2005-08-17 00:00:00

abstract：BACKGROUND:Simple sequence repeats (SSRs) have become widely used as molecular markers in plant genetic studies due to their abundance, high allelic variation at each locus and simplicity to analyze using conventional PCR amplification. To study plants with unknown genome sequence, SSR markers from Expressed Sequence T...

journal_title：BMC genomics

authors： Ponyared P,Ponsawat J,Tongsima S,Seresangtakul P,Akkasaeng C,Tantisuwichwong N

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:Photorhabdus luminescens is an enteric bacterium, which lives in mutualistic association with soil nematodes and is highly pathogenic for a broad spectrum of insects. A complete genome sequence for the type strain P. luminescens subsp. laumondii TT01, which was originally isolated in Trinidad and Tobago, has...

journal_title：BMC genomics

authors： Zamora-Lagos MA,Eckstein S,Langer A,Gazanis A,Pfeiffer F,Habermann B,Heermann R

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:A major goal of post-genomics research is the integrated analysis of genes, regulatory elements and the chromatin architecture on a genome-wide scale. Mapping DNase I hypersensitive sites within the nuclear chromatin is a powerful and well-established method of identifying regulatory element candidates. RES...

journal_title：BMC genomics

authors： Shi B,Guo X,Wu T,Sheng S,Wang J,Skogerbø G,Zhu X,Chen R

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNAs that regulate genes at the post-transcriptional level in spatiotemporal manner. Several miRNAs are identified as prognostic and diagnostic markers in many human cancers. Estimation of the temporal activities of the miRNAs is an important step in the way to underst...

journal_title：BMC genomics

authors： Jayavelu ND,Bar N

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:RNA-seq and microarray are the two popular methods employed for genome-wide transcriptome profiling. Current comparison studies have shown that transcriptome quantified by these two methods correlated well. However, none of them have addressed if they complement each other, considering the strengths and the ...

journal_title：BMC genomics

authors： Kogenaru S,Qing Y,Guo Y,Wang N

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Crohn's disease (CD) is an inflammatory bowel disease caused by genetic and environmental factors. More than 160 susceptibility loci have been identified for IBD, yet a large part of the genetic variance remains unexplained. Recent studies have demonstrated genetic differences between monozygotic twins, who ...

journal_title：BMC genomics

authors： Petersen BS,Spehlmann ME,Raedler A,Stade B,Thomsen I,Rabionet R,Rosenstiel P,Schreiber S,Franke A

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:It is unclear whether improving feed efficiency by selection for low residual feed intake (RFI) compromises pigs' immunocompetence. Here, we aimed at investigating whether pig lines divergently selected for RFI had different inflammatory responses to lipopolysaccharide (LPS) exposure, regarding to clinical p...

journal_title：BMC genomics

authors： Liu H,Feye KM,Nguyen YT,Rakhshandeh A,Loving CL,Dekkers JCM,Gabler NK,Tuggle CK

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Zoysia matrella, widely used in lawns and sports fields, is of great economic and ecological value. Z. matrella is an allotetraploid species (2n = 4x = 40) in the genus zoysia under the subfamily Chloridoideae. Despite its ecological impacts and economic importance, the subfamily Chloridoideae has received l...

journal_title：BMC genomics

authors： Huang X,Wang F,Singh R,Reinert JA,Engelke MC,Genovesi AD,Chandra A,Yu Q

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Bloodstream malaria parasites require Ca++ for their development, but the sites and mechanisms of Ca++ utilization are not well understood. We hypothesized that there may be differences in Ca++ uptake or utilization by genetically distinct lines of P. falciparum. These differences, if identified, may provide...

journal_title：BMC genomics

authors： Apolis L,Olivas J,Srinivasan P,Kushwaha AK,Desai SA

更新日期：2019-01-16 00:00:00

abstract：MOTIVATION:Deciphering gene interaction networks (GINs) from time-course gene expression (TCGx) data is highly valuable to understand gene behaviors (e.g., activation, inhibition, time-lagged causality) at the system level. Existing methods usually use a global or local proximity measure to infer GINs from a single dat...

journal_title：BMC genomics

authors： Liu Q,Song R,Li J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Musa species (Zingiberaceae, Zingiberales) including bananas and plantains are collectively the fourth most important crop in developing countries. Knowledge concerning Musa genome structure and the origin of distinct cultivars has greatly increased over the last few years. Until now, however, no large-scale...

journal_title：BMC genomics

authors： Lescot M,Piffanelli P,Ciampi AY,Ruiz M,Blanc G,Leebens-Mack J,da Silva FR,Santos CM,D'Hont A,Garsmeur O,Vilarinhos AD,Kanamori H,Matsumoto T,Ronning CM,Cheung F,Haas BJ,Althoff R,Arbogast T,Hine E,Pappas GJ Jr,Sas

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:Magnesium (Mg)-deficiency is frequently observed in Citrus plantations and is responsible for the loss of productivity and poor fruit quality. Knowledge on the effects of Mg-deficiency on upstream targets is scarce. Seedlings of 'Xuegan' [Citrus sinensis (L.) Osbeck] were irrigated with Mg-deficient (0 mM Mg...

journal_title：BMC genomics

authors： Peng HY,Qi YP,Lee J,Yang LT,Guo P,Jiang HX,Chen LS

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:In many eukaryotes, microRNAs (miRNAs) bind to complementary sites in the 3'-untranslated regions (3'-UTRs) of target messenger RNAs (mRNAs) and regulate their expression at the stage of translation. Recent studies have revealed that many miRNAs are evolutionarily conserved; however, the evolution of their t...

journal_title：BMC genomics

authors： Takane K,Fujishima K,Watanabe Y,Sato A,Saito N,Tomita M,Kanai A

更新日期：2010-02-09 00:00:00

abstract：BACKGROUND:Intergenic splicing resulting in the combination of mRNAs sequences from distinct genes is a newly identified mechanism likely to contribute to protein diversity. Few cases have been described, most of them involving neighboring genes and thus suggesting a cotranscription event presumably due to transcriptio...

journal_title：BMC genomics

authors： Roux M,Levéziel H,Amarger V

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:Phytophthora species are oomycete plant pathogens with such major social and economic impact that genome sequences have been determined for Phytophthora infestans, P. sojae and P. ramorum. Pepsin-like aspartic proteinases (APs) are produced in a wide variety of species (from bacteria to humans) and contain c...

journal_title：BMC genomics

authors： Kay J,Meijer HJ,ten Have A,van Kan JA

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Post-translational modification (PTM) of proteins is central to many cellular processes across all domains of life, but despite decades of study and a wealth of genomic and proteomic data the biological function of many PTMs remains unknown. This is especially true for prokaryotic PTM systems, many of which ...

journal_title：BMC genomics

authors： Brown CW,Sridhara V,Boutz DR,Person MD,Marcotte EM,Barrick JE,Wilke CO

更新日期：2017-04-17 00:00:00