Genome-wide profiling of G protein-coupled receptors in cerebellar granule neurons using high-throughput, real-time PCR.

abstract：BACKGROUND:Advances in whole genome profiling have revolutionized the cancer research field, but at the same time have raised new bioinformatics challenges. For next generation sequencing (NGS), these include data storage, computational costs, sequence processing and alignment, delineating appropriate statistical measu...

journal_title：BMC genomics

authors： Rodriguez BA,Frankhouser D,Murphy M,Trimarchi M,Tam HH,Curfman J,Huang R,Chan MW,Lai HC,Parikh D,Ball B,Schwind S,Blum W,Marcucci G,Yan P,Bundschuh R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Banana wilt disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4 (Foc TR4), is one of the most devastating diseases in banana (Musa spp.). Foc is a soil borne pathogen that causes rot of the roots or wilt of leaves by colonizing the xylem vessels. The dual RNA sequencing is used to simultaneo...

journal_title：BMC genomics

authors： Li W,Wang X,Li C,Sun J,Li S,Peng M

更新日期：2019-06-24 00:00:00

abstract：BACKGROUND:Daphnia (Crustacea: Cladocera) plays a central role in standing aquatic ecosystems, has a well known ecology and is widely used in population studies and environmental risk assessments. Daphnia magna is, especially in Europe, intensively used to study stress responses of natural populations to pollutants, cl...

journal_title：BMC genomics

authors： Orsini L,Jansen M,Souche EL,Geldof S,De Meester L

更新日期：2011-06-13 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from lean and obese mice. The deg...

journal_title：BMC genomics

authors： Link JC,Hasin-Brumshtein Y,Cantor RM,Chen X,Arnold AP,Lusis AJ,Reue K

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:The human neuroblastoma cell line, SH-SY5Y, is a commonly used cell line in studies related to neurotoxicity, oxidative stress, and neurodegenerative diseases. Although this cell line is often used as a cellular model for Parkinson's disease, the relevance of this cellular model in the context of Parkinson's...

journal_title：BMC genomics

authors： Krishna A,Biryukov M,Trefois C,Antony PM,Hussong R,Lin J,Heinäniemi M,Glusman G,Köglsberger S,Boyd O,van den Berg BH,Linke D,Huang D,Wang K,Hood L,Tholey A,Schneider R,Galas DJ,Balling R,May P

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:The cellular proteome and metabolome are underlying dynamic regulation allowing rapid adaptation to changes in the environment. System-wide analysis of these dynamics will provide novel insights into mechanisms of stress adaptation for higher photosynthetic organisms. We applied pulsed-SILAC labeling to a ph...

journal_title：BMC genomics

authors： Mastrobuoni G,Irgang S,Pietzke M,Assmus HE,Wenzel M,Schulze WX,Kempa S

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Fungal pathogens of plants produce diverse repertoires of secondary metabolites, which have functions ranging from iron acquisition, defense against immune perturbation, to toxic assaults on the host. The wheat pathogen Zymoseptoria tritici causes Septoria tritici blotch, a foliar disease which is a signific...

journal_title：BMC genomics

authors： Cairns T,Meyer V

更新日期：2017-08-17 00:00:00

abstract：BACKGROUND:Sugarcane smut is a fungal disease caused by Sporisorium scitamineum. Cultivation of smut-resistant sugarcane varieties is the most effective way to control this disease. The interaction between sugarcane and S. scitamineum is a complex network system. However, to date, there is no report on the identificati...

journal_title：BMC genomics

authors： Su Y,Xiao X,Ling H,Huang N,Liu F,Su W,Zhang Y,Xu L,Muhammad K,Que Y

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:The genomic organisation of the Major Histocompatibility Complex (MHC) varies greatly between different vertebrates. In mammals, the classical MHC consists of a large number of linked genes (e.g. greater than 200 in humans) with predominantly immune function. In some birds, it consists of only a small number...

journal_title：BMC genomics

authors： Sambrook JG,Figueroa F,Beck S

更新日期：2005-11-04 00:00:00

abstract：BACKGROUND:The increasing use of DNA microarrays for genetical genomics studies generates a need for platforms with complete coverage of the genome. We have compared the effective gene coverage in the mouse genome of different commercial and noncommercial oligonucleotide microarray platforms by performing an in-house g...

journal_title：BMC genomics

authors： Verdugo RA,Medrano JF

更新日期：2006-03-21 00:00:00

abstract：BACKGROUND:Plants respond to low temperature through an intricately coordinated transcriptional network. The CBF/DREB-regulated network of genes has been shown to play a prominent role in freeze-tolerance of Arabidopsis through the process of cold acclimation (CA). Recent evidence also showed that the CBF/DREB regulon ...

journal_title：BMC genomics

authors： Cheng C,Yun KY,Ressom HW,Mohanty B,Bajic VB,Jia Y,Yun SJ,de los Reyes BG

更新日期：2007-06-18 00:00:00

abstract：BACKGROUND:Advances in human genomics have allowed unprecedented productivity in terms of algorithms, software, and literature available for translating raw next-generation sequence data into high-quality information. The challenges of variant identification in organisms with lower quality reference genomes are less we...

journal_title：BMC genomics

authors： Baes CF,Dolezal MA,Koltes JE,Bapst B,Fritz-Waters E,Jansen S,Flury C,Signer-Hasler H,Stricker C,Fernando R,Fries R,Moll J,Garrick DJ,Reecy JM,Gredler B

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Democratising the growing body of whole genome sequencing data available for Triticum aestivum (bread wheat) has been impeded by the lack of a genome reference and the large computational requirements for analysing these data sets. RESULTS:DAWN (Diversity Among Wheat geNomes) integrates data from the T. aes...

journal_title：BMC genomics

authors： Watson-Haigh NS,Suchecki R,Kalashyan E,Garcia M,Baumann U

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Maternal effects contribute to adaptive significance for shaping various phenotypes of many traits. Potential implications of maternal effects are the cause of expression diversity, but these effects on mRNA expression and alternative splicing (AS) have not been fully elucidated in hybrid animals. RESULTS:T...

journal_title：BMC genomics

authors： Ren L,Yan X,Gao X,Cui J,Yan P,Wu C,Li W,Liu S

更新日期：2020-07-02 00:00:00

abstract：BACKGROUND:The contribution of genetic factors to the development of breast cancer in the admixed and consanguineous population of the western region of Saudi Arabia is thought to be significant as the disease is early onset. The current protocols of continuous clinical follow-up of relatives of such patients are costl...

journal_title：BMC genomics

authors： Merdad A,Gari MA,Hussein S,Al-Khayat S,Tashkandi H,Al-Maghrabi J,Al-Thubaiti F,Hussein IR,Koumosani T,Shaer N,Chaudhary AG,Abuzenadah AM,Al-Qahtani MH,Dallol A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The papaya Y chromosome has undergone a degenerative expansion from its ancestral autosome, as a consequence of recombination suppression in the sex determining region of the sex chromosomes. The non-recombining feature led to the accumulation of repetitive sequences in the male- or hermaphrodite-specific re...

journal_title：BMC genomics

authors： Na JK,Wang J,Ming R

更新日期：2014-05-04 00:00:00

abstract：BACKGROUND:Homologous recombination is the key process that generates genetic diversity and drives evolution. SPO11 protein triggers recombination by introducing DNA double stranded breaks at discreet areas of the genome called recombination hotspots. The hotspot locations are largely determined by the DNA binding spec...

journal_title：BMC genomics

authors： Smagulova F,Brick K,Pu Y,Sengupta U,Camerini-Otero RD,Petukhova GV

更新日期：2013-07-22 00:00:00

abstract：BACKGROUND:Volvox carteri (V. carteri) is a multicellular green alga used as model system for the evolution of multicellularity. So far, the contribution of small RNA pathways to these phenomena is not understood. Thus, we have sequenced V. carteri Argonaute 3 (VcAGO3)-associated small RNAs from different developmental...

journal_title：BMC genomics

authors： Dueck A,Evers M,Henz SR,Unger K,Eichner N,Merkl R,Berezikov E,Engelmann JC,Weigel D,Wenzl S,Meister G

更新日期：2016-11-02 00:00:00

abstract：BACKGROUND:HPA axis plays a major role in physiological homeostasis. It is also involved in stress and adaptive response to the environment. In farm animals in general and specifically in pigs, breeding strategies have highly favored production traits such as lean growth rate, feed efficiency and prolificacy at the cos...

journal_title：BMC genomics

authors： Sautron V,Terenina E,Gress L,Lippi Y,Billon Y,Larzul C,Liaubet L,Villa-Vialaneix N,Mormède P

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:The recently developed RNA interference (RNAi) technology has created an unprecedented opportunity which allows the function of individual genes in whole organisms or cell lines to be interrogated at genome-wide scale. However, multiple issues, such as off-target effects or low efficacies in knocking down ce...

journal_title：BMC genomics

authors： Wang L,Tu Z,Sun F

更新日期：2009-05-12 00:00:00

abstract：BACKGROUND:Ramularia collo-cygni is a newly important, foliar fungal pathogen of barley that causes the disease Ramularia leaf spot. The fungus exhibits a prolonged endophytic growth stage before switching life habit to become an aggressive, necrotrophic pathogen that causes significant losses to green leaf area and he...

journal_title：BMC genomics

authors： McGrann GR,Andongabo A,Sjökvist E,Trivedi U,Dussart F,Kaczmarek M,Mackenzie A,Fountaine JM,Taylor JM,Paterson LJ,Gorniak K,Burnett F,Kanyuka K,Hammond-Kosack KE,Rudd JJ,Blaxter M,Havis ND

更新日期：2016-08-09 00:00:00

abstract：BACKGROUND:Leishmaniasis is a neglected tropical disease with diverse clinical phenotypes, determined by parasite, host and vector interactions. Despite the advances in molecular biology and the availability of more Leishmania genome references in recent years, the association between parasite species and distinct clin...

journal_title：BMC genomics

authors： Samarasinghe SR,Samaranayake N,Kariyawasam UL,Siriwardana YD,Imamura H,Karunaweera ND

更新日期：2018-11-28 00:00:00

abstract：BACKGROUND:The sRNAs of bacterial pathogens are known to be involved in various cellular roles including environmental adaptation as well as regulation of virulence and pathogenicity. It is expected that sRNAs may also have similar functions for Burkholderia pseudomallei, a soil bacterium that can adapt to diverse envi...

journal_title：BMC genomics

authors： Khoo JS,Chai SF,Mohamed R,Nathan S,Firdaus-Raih M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Studying mitochondrial (mt) genomics has important implications for various fundamental areas, including mt biochemistry, physiology and molecular biology. In addition, mt genome sequences have provided useful markers for investigating population genetic structures, systematics and phylogenetics of organisms...

journal_title：BMC genomics

authors： Li MW,Lin RQ,Song HQ,Wu XY,Zhu XQ

更新日期：2008-05-16 00:00:00

abstract：BACKGROUND:The tuberous root of sweet potato is an important agricultural and biological organ. There are not sufficient transcriptomic and genomic data in public databases for understanding of the molecular mechanism underlying the tuberous root formation and development. Thus, high throughput transcriptome sequencing...

journal_title：BMC genomics

authors： Wang Z,Fang B,Chen J,Zhang X,Luo Z,Huang L,Chen X,Li Y

更新日期：2010-12-24 00:00:00

abstract：BACKGROUND:Repeat masking is an important step in the EST analysis pipeline. For new species, genomic knowledge is scarce and good repeat libraries are typically unavailable. In these cases it is common practice to mask against known repeats from other species (i.e., model organisms). There are few studies that investi...

journal_title：BMC genomics

authors： Malde K,Jonassen I

更新日期：2008-01-18 00:00:00

abstract：BACKGROUND:Cryptosporidium hominis is a dominant species for human cryptosporidiosis. Within the species, IbA10G2 is the most virulent subtype responsible for all C. hominis-associated outbreaks in Europe and Australia, and is a dominant outbreak subtype in the United States. In recent yearsIaA28R4 is becoming a major ...

journal_title：BMC genomics

authors： Guo Y,Tang K,Rowe LA,Li N,Roellig DM,Knipe K,Frace M,Yang C,Feng Y,Xiao L

更新日期：2015-04-18 00:00:00

abstract：BACKGROUND:Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend themselves against ROS/RNS, bacteria possess a subsystem of detoxification enzymes, which are classi...

journal_title：BMC genomics

authors： Thybert D,Avner S,Lucchetti-Miganeh C,Chéron A,Barloy-Hubler F

更新日期：2008-12-31 00:00:00

abstract：BACKGROUND:DNA methylation is associated with aberrant gene expression in cancer, and has been shown to correlate with therapeutic response and disease prognosis in some types of cancer. We sought to investigate the biological significance of DNA methylation in lung cancer. RESULTS:We integrated the gene expression pr...

journal_title：BMC genomics

authors： Lin SH,Wang J,Saintigny P,Wu CC,Giri U,Zhang J,Menju T,Diao L,Byers L,Weinstein JN,Coombes KR,Girard L,Komaki R,Wistuba II,Date H,Minna JD,Heymach JV

更新日期：2014-12-08 00:00:00

abstract：BACKGROUND:Chloroplasts have their own genomes, independent from nuclear genomes, that play vital roles in growth, which is a major targeted trait for genetic improvement in Populus. Angiosperm chloroplast genomes are maternally inherited, but the chloroplast' variation pattern of poplar at the single-base level during...

journal_title：BMC genomics

authors： Zhu S,Xu M,Wang H,Pan H,Wang G,Huang M

更新日期：2018-05-29 00:00:00