Abstract:
BACKGROUND:Democratising the growing body of whole genome sequencing data available for Triticum aestivum (bread wheat) has been impeded by the lack of a genome reference and the large computational requirements for analysing these data sets. RESULTS:DAWN (Diversity Among Wheat geNomes) integrates data from the T. aestivum Chinese Spring (CS) IWGSC RefSeq v1.0 genome with public WGS and exome data from 17 and 62 accessions respectively, enabling researchers and breeders alike to investigate genotypic differences between wheat accessions at the level of whole chromosomes down to individual genes. CONCLUSIONS:Using DAWN we show that it is possible to visualise small and large chromosomal deletions, identify haplotypes at a glance and spot the consequences of selective breeding. DAWN allows us to detect the break points of alien introgression segments brought into an accession when transferring desired genes. Furthermore, we can find possible explanations for reduced recombination in parts of a chromosome, we can predict regions with linkage drag, and also look at diversity in centromeric regions.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Watson-Haigh NS,Suchecki R,Kalashyan E,Garcia M,Baumann Udoi
10.1186/s12864-018-5228-2subject
Has Abstractpub_date
2018-12-17 00:00:00pages
941issue
1issn
1471-2164pii
10.1186/s12864-018-5228-2journal_volume
19pub_type
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