Accumulation of interspersed and sex-specific repeats in the non-recombining region of papaya sex chromosomes.

abstract：BACKGROUND:BAC-based physical maps provide for sequencing across an entire genome or a selected sub-genomic region of biological interest. Such a region can be approached with next-generation whole-genome sequencing and assembly as if it were an independent small genome. Using the minimum tiling path as a guide, specif...

journal_title：BMC genomics

authors： Feltus FA,Saski CA,Mockaitis K,Haiminen N,Parida L,Smith Z,Ford J,Staton ME,Ficklin SP,Blackmon BP,Cheng CH,Schnell RJ,Kuhn DN,Motamayor JC

更新日期：2011-07-27 00:00:00

abstract：BACKGROUND:The spiral cleavage mode of early development is utilized in over one-third of all animal phyla and generates embryonic cells of different size, position, and fate through a conserved set of stereotypic and invariant asymmetric cell divisions. Despite the widespread use of spiral cleavage, regulatory and mol...

journal_title：BMC genomics

authors： Chou HC,Pruitt MM,Bastin BR,Schneider SQ

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:There is strong but mostly circumstantial evidence that genetic factors modulate the severity of influenza infection in humans. Using genetically diverse but fully inbred strains of mice it has been shown that host sequence variants have a strong influence on the severity of influenza A disease progression. ...

journal_title：BMC genomics

authors： Nedelko T,Kollmus H,Klawonn F,Spijker S,Lu L,Heßman M,Alberts R,Williams RW,Schughart K

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However, there is no information about the changes produced by the wounds...

journal_title：BMC genomics

authors： Cordero H,Brinchmann MF,Cuesta A,Esteban MA

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:The Yesso scallop, Patinopecten (Mizuhopecten) yessoensis, is a commercially important bivalve in the coastal countries of Northeast Asia. It has complex modes of sex differentiation, but knowledge of the mechanisms underlying this sex determination and differentiation is limited. RESULTS:In this study, the...

journal_title：BMC genomics

authors： Zhou L,Liu Z,Dong Y,Sun X,Wu B,Yu T,Zheng Y,Yang A,Zhao Q,Zhao D

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:Protein effectors of pathogenicity are instrumental in modulating host immunity and disease resistance. The powdery mildew pathogen of grasses Blumeria graminis causes one of the most important diseases of cereal crops. B. graminis is an obligate biotrophic pathogen and as such has an absolute requirement to...

journal_title：BMC genomics

authors： Pedersen C,Ver Loren van Themaat E,McGuffin LJ,Abbott JC,Burgis TA,Barton G,Bindschedler LV,Lu X,Maekawa T,Wessling R,Cramer R,Thordal-Christensen H,Panstruga R,Spanu PD

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Adult neurogenesis, which is the continual production of new neurons in the mature brain, demonstrates the strikingly plastic nature of the nervous system. Adult neural stem cells and their neural precursors, collectively referred to as neural progenitor cells (NPCs), are present in the subgranular zone (SGZ...

journal_title：BMC genomics

authors： Poon A,Goldowitz D

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Streptococcus infantarius subsp. infantarius (Sii) belongs to the Streptococcus bovis/Streptococcus equinus complex associated with several human and animal infections. Sii is a predominant bacterium in spontaneously fermented milk products in Africa. The genome sequence of Sii strain CJ18 was compared with ...

journal_title：BMC genomics

authors： Jans C,Follador R,Hochstrasser M,Lacroix C,Meile L,Stevens MJ

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:Large difference in cerebrum size exist between avian species and populations of the same species and is believed to reflect differences in processing power, i.e. in the speed and efficiency of processing information in this brain region. During domestication chickens developed a larger cerebrum compared to ...

journal_title：BMC genomics

authors： Höglund A,Strempfl K,Fogelholm J,Wright D,Henriksen R

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:Nontuberculous mycobacterium (NTM) species are ubiquitous microorganisms. NTM pulmonary disease (NTM-PD) is thought to be caused not by human-to-human transmission but by independent environmental acquisition. However, recent studies using next-generation sequencing (NGS) have reported trans-continental spre...

journal_title：BMC genomics

authors： Yoon JK,Kim TS,Kim JI,Yim JJ

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Second generation sequencing has permitted detailed sequence characterisation at the whole genome level of a growing number of non-model organisms, but the data produced have short read-lengths and biased genome coverage leading to fragmented genome assemblies. The PacBio RS long-read sequencing platform off...

journal_title：BMC genomics

authors： Ferrarini M,Moretto M,Ward JA,Šurbanovski N,Stevanović V,Giongo L,Viola R,Cavalieri D,Velasco R,Cestaro A,Sargent DJ

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Protein structure comparison and classification is an effective method for exploring protein structure-function relations. This problem is computationally challenging. Many different computational approaches for protein structure comparison apply the secondary structure elements (SSEs) representation of prot...

journal_title：BMC genomics

authors： Ashby C,Johnson D,Walker K,Kanj IA,Xia G,Huang X

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The Iberian lynx (Lynx pardinus) has been acknowledged as the most endangered felid species in the world. An intense contraction and fragmentation during the twentieth century left less than 100 individuals split in two isolated and genetically eroded populations by 2002. Genetic monitoring and management so...

journal_title：BMC genomics

authors： Kleinman-Ruiz D,Martínez-Cruz B,Soriano L,Lucena-Perez M,Cruz F,Villanueva B,Fernández J,Godoy JA

更新日期：2017-07-21 00:00:00

abstract：BACKGROUND:Accurate gene model predictions and annotation of alternative splicing events are imperative for genomic studies in organisms that contain genes with multiple exons. Currently most gene models for the intracellular parasite, Toxoplasma gondii, are based on computer model predictions without cDNA sequence ver...

journal_title：BMC genomics

authors： Hassan MA,Melo MB,Haas B,Jensen KD,Saeij JP

更新日期：2012-12-12 00:00:00

abstract：BACKGROUND:Adenosine to inosine (A-to-I) RNA-editing is an essential post-transcriptional mechanism that occurs in numerous sites in the human transcriptome, mainly within Alu repeats. It has been shown to have consistent levels of editing across individuals in a few targets in the human brain and altered in several hu...

journal_title：BMC genomics

authors： Greenberger S,Levanon EY,Paz-Yaacov N,Barzilai A,Safran M,Osenberg S,Amariglio N,Rechavi G,Eisenberg E

更新日期：2010-10-28 00:00:00

abstract：BACKGROUND:Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cellular function. Most metazoan proteins are composed of structural and/or functional domains, of which many appear in multiple proteins. Once a domain is characterized in on...

journal_title：BMC genomics

authors： Kemmer D,Podowski RM,Arenillas D,Lim J,Hodges E,Roth P,Sonnhammer EL,Höög C,Wasserman WW

更新日期：2006-03-13 00:00:00

abstract：BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...

journal_title：BMC genomics

authors： Dreisigacker S,Sharma RK,Huttner E,Karimov A,Obaidi MQ,Singh PK,Sansaloni C,Shrestha R,Sonder K,Braun HJ

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Ser/Thr/Tyr kinases (STYKs) commonly found in eukaryotes have been recently reported in many bacterial species. Recent studies elucidating their cellular functions have established their roles in bacterial growth and development. However functions of a large number of bacterial STYKs still remain elusive. Th...

journal_title：BMC genomics

authors： Krupa A,Srinivasan N

更新日期：2005-09-19 00:00:00

abstract：BACKGROUND:Biocontrol of bacterial pathogens by bacteriophages (phages) represents a promising strategy. Vibrio alginolyticus, a gram-negative bacterium, is a notorious pathogen responsible for the loss of economically important farmed marine animals. To date, few V. alginolyticus phages have been successfully isolated...

journal_title：BMC genomics

authors： Luo P,Yun L,Li Y,Tian Y,Liu Q,Huang W,Hu C

更新日期：2018-10-11 00:00:00

abstract：BACKGROUND:Dinoflagellates are unicellular marine and freshwater eukaryotes. They possess large nuclear genomes (1.5-245 gigabases) and produce structurally unique and biologically active polyketide secondary metabolites. Although polyketide biosynthesis is well studied in terrestrial and freshwater organisms, only rec...

journal_title：BMC genomics

authors： Beedessee G,Hisata K,Roy MC,Satoh N,Shoguchi E

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Prediction methods are increasingly used in biosciences to forecast diverse features and characteristics. Binary two-state classifiers are the most common applications. They are usually based on machine learning approaches. For the end user it is often problematic to evaluate the true performance and applica...

journal_title：BMC genomics

authors： Vihinen M

更新日期：2012-06-18 00:00:00

abstract：BACKGROUND:It has been shown previously that aminocoumarin antibiotics such as novobiocin lead to immediate downregulation of recA expression and thereby inhibit the SOS response, mutation frequency and recombination capacity in Staphylococcus aureus. Aminocoumarins function by inhibiting the ATPase activity of DNA gyr...

journal_title：BMC genomics

authors： Schröder W,Bernhardt J,Marincola G,Klein-Hitpass L,Herbig A,Krupp G,Nieselt K,Wolz C

更新日期：2014-04-16 00:00:00

abstract：BACKGROUND:Studies of gene regulation often utilize genome-wide predictions of transcription factor (TF) binding sites. Most existing prediction methods are based on sequence information alone, ignoring biological contexts such as developmental stages and tissue types. Experimental methods to study in vivo binding, inc...

journal_title：BMC genomics

authors： Zhong S,He X,Bar-Joseph Z

更新日期：2013-11-15 00:00:00

abstract：BACKGROUND:The MHC and KIR loci are clinically relevant regions of the genome. Typing the sequence of these loci has a wide range of applications including organ transplantation, drug discovery, pharmacogenomics and furthering fundamental research in immune genetics. Rapid advances in biochemical and next-generation se...

journal_title：BMC genomics

authors： Selvaraj S,Schmitt AD,Dixon JR,Ren B

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:Diversification on the basis of utilization is a hallmark of Beta vulgaris (beet), as well as other crop species. Often, crop improvement and management activities are segregated by crop type, thus preserving unique genome diversity and organization. Full interfertility is typically retained in crosses betwe...

journal_title：BMC genomics

authors： Galewski P,McGrath JM

更新日期：2020-03-02 00:00:00

abstract：BACKGROUND:Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias. RESULTS:In this study we have sampled over 800 unrelated individuals from the population of Spain,...

journal_title：BMC genomics

authors： Gayán J,Galan JJ,González-Pérez A,Sáez ME,Martínez-Larrad MT,Zabena C,Rivero MC,Salinas A,Ramírez-Lorca R,Morón FJ,Royo JL,Moreno-Rey C,Velasco J,Carrasco JM,Molero E,Ochoa C,Ochoa MD,Gutiérrez M,Reina M,Pascual R,

更新日期：2010-05-25 00:00:00

abstract：BACKGROUND:Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease which causes great economic losses worldwide. Many virulence factors are involved in the pathogenesis, namely capsular polysaccharides, RTX toxins, LPS and many iron acquisition systems. In order to ide...

journal_title：BMC genomics

authors： Deslandes V,Denicourt M,Girard C,Harel J,Nash JH,Jacques M

更新日期：2010-02-08 00:00:00

abstract：BACKGROUND:The compromised performance of laying hens in the late phase of production relative to the peak production was thought to be associated with the impairment of intestinal functionality, which plays essential roles in contributing to their overall health and production performance. In the present study, RNA se...

journal_title：BMC genomics

authors： Wang WW,Wang J,Zhang HJ,Wu SG,Qi GH

更新日期：2019-12-12 00:00:00

abstract：BACKGROUND:Human leucocyte antigen (HLA) genes play an important role in determining the outcome of organ transplantation and are linked to many human diseases. Because of the diversity and polymorphisms of HLA loci, HLA typing at high resolution is challenging even with whole-genome sequencing data. RESULTS:We have d...

journal_title：BMC genomics

authors： Nariai N,Kojima K,Saito S,Mimori T,Sato Y,Kawai Y,Yamaguchi-Kabata Y,Yasuda J,Nagasaki M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Although the needs for analyses of secondary structures of RNAs are increasing, prediction of the secondary structures of RNAs are not always reliable. Because an RNA may have a complicated energy landscape, comprehensive representations of the whole ensemble of the secondary structures, such as the probabil...

journal_title：BMC genomics

authors： Mori R,Hamada M,Asai K

更新日期：2014-01-01 00:00:00