Altering gene expression by aminocoumarins: the role of DNA supercoiling in Staphylococcus aureus.

abstract：BACKGROUND:The astounding regenerative abilities of planarian flatworms prompt steadily growing interest in examining their molecular foundation. Planarian regeneration was found to require hundreds of genes and is hence a complex process. Thus, RNA interference followed by transcriptome-wide gene expression analysis b...

journal_title：BMC genomics

authors： Kim IV,Ross EJ,Dietrich S,Döring K,Sánchez Alvarado A,Kuhn CD

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Descriptive hierarchical Poisson models and population-genetic coalescent mixture models are used to describe the observed variation in single-nucleotide polymorphism (SNP) density from samples of size two across the human genome. RESULTS:Using empirical estimates of recombination rate across the human geno...

journal_title：BMC genomics

authors： Sainudiin R,Clark AG,Durrett RT

更新日期：2007-06-06 00:00:00

abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) is a major signaling molecule that the brain uses to control a vast network of intracellular cascades fundamental to properties of learning and memory, and cognition. While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen ...

journal_title：BMC genomics

authors： Hixson KM,Cogswell M,Brooks-Kayal AR,Russek SJ

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Crustaceans have been studied extensively as model systems for nervous system function from single neuron properties to behavior. However, lack of molecular sequence information and tools have slowed the adoption of these physiological systems as molecular model systems. In this study, we sequenced and perfo...

journal_title：BMC genomics

authors： Northcutt AJ,Lett KM,Garcia VB,Diester CM,Lane BJ,Marder E,Schulz DJ

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Sorghum belongs to the tribe of the Andropogoneae that includes potential biofuel crops like switchgrass, Miscanthus and successful biofuel crops like corn and sugarcane. However, from a genomics point of view sorghum has compared to these other species a simpler genome because it lacks the additional rounds...

journal_title：BMC genomics

authors： Calviño M,Bruggmann R,Messing J

更新日期：2011-07-08 00:00:00

abstract：BACKGROUND:The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 function was unclear. RESULTS:We report the first genome-wide identification and characterization o...

journal_title：BMC genomics

authors： O'Geen H,Lin YH,Xu X,Echipare L,Komashko VM,He D,Frietze S,Tanabe O,Shi L,Sartor MA,Engel JD,Farnham PJ

更新日期：2010-12-02 00:00:00

abstract：BACKGROUND:Theileria parva is an intracellular parasite that causes a lymphoproliferative disease in cattle. It does so by inducing cancer-like phenotypes in the host cells it infects, although the molecular and regulatory mechanisms involved remain poorly understood. RNAseq data, and the resulting updated genome annot...

journal_title：BMC genomics

authors： Tretina K,Pelle R,Silva JC

更新日期：2016-02-20 00:00:00

abstract：BACKGROUND:It is becoming apparent that perhaps as much as half of the genome of the human blood fluke Schistosoma mansoni is constituted of mobile genetic element-related sequences. Non-long terminal repeat (LTR) retrotransposons, related to the LINE elements of mammals, comprise much of this repetitive component of t...

journal_title：BMC genomics

authors： Laha T,Kewgrai N,Loukas A,Brindley PJ

更新日期：2005-11-04 00:00:00

abstract：BACKGROUND:The approaches for shotgun-based sequencing of vertebrate genomes are now well-established, and have resulted in the generation of numerous draft whole-genome sequence assemblies. In contrast, the process of refining those assemblies to improve contiguity and increase accuracy (known as 'sequence finishing')...

journal_title：BMC genomics

authors： Blakesley RW,Hansen NF,Gupta J,McDowell JC,Maskeri B,Barnabas BB,Brooks SY,Coleman H,Haghighi P,Ho SL,Schandler K,Stantripop S,Vogt JL,Thomas PJ,NISC Comparative Sequencing Program.,Bouffard GG,Green ED

更新日期：2010-01-11 00:00:00

abstract：BACKGROUND:Distinguishing orthologous and paralogous relationships between genes across multiple species is essential for comparative genomic analyses. Various computational approaches have been developed to resolve these evolutionary relationships, but strong trade-offs between precision and recall of orthologue predi...

journal_title：BMC genomics

authors： Rane RV,Oakeshott JG,Nguyen T,Hoffmann AA,Lee SF

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes - and thus for conserved secondary structures - even in genomic reg...

journal_title：BMC genomics

authors： Kirsch R,Seemann SE,Ruzzo WL,Cohen SM,Stadler PF,Gorodkin J

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:Gene duplication underlies a significant proportion of gene functional diversity and genome complexity in both eukaryotes and prokaryotes. Although several reports in the literature described the duplication of specific genes in E. coli, a detailed analysis of the extent of gene duplications in this microorg...

journal_title：BMC genomics

authors： Bernabeu M,Sánchez-Herrero JF,Huedo P,Prieto A,Hüttener M,Rozas J,Juárez A

更新日期：2019-04-24 00:00:00

abstract：BACKGROUND:The reconstruction of gene regulatory networks from high-throughput "omics" data has become a major goal in the modelling of living systems. Numerous approaches have been proposed, most of which attempt only "one-shot" reconstruction of the whole network with no intervention from the user, or offer only simp...

journal_title：BMC genomics

authors： Kadupitige SR,Leung KC,Sellmeier J,Sivieng J,Catchpoole DR,Bain ME,Gaëta BA

更新日期：2009-12-03 00:00:00

abstract：BACKGROUND:Cattle and other ruminants have evolved the ability to derive most of their metabolic energy requirement from otherwise indigestible plant matter through a symbiotic relationship with plant fibre degrading microbes within a specialised fermentation chamber, the rumen. The genetic changes underlying the evolu...

journal_title：BMC genomics

authors： Wheeler TT,Hood KA,Maqbool NJ,McEwan JC,Bingle CD,Zhao S

更新日期：2007-03-15 00:00:00

abstract：BACKGROUND:In a previous genome-wide analysis of FXR binding to hepatic chromatin, we noticed that an extra nuclear receptor (NR) half-site was co-enriched close to the FXR binding IR-1 elements and we provided limited support that the monomeric LRH-1 receptor that binds to NR half-sites might function together with FX...

journal_title：BMC genomics

authors： Chong HK,Biesinger J,Seo YK,Xie X,Osborne TF

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The androgen receptor plays a critical role throughout the progression of prostate cancer and is an important drug target for this disease. While chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) is becoming an essential tool for studying transcription and chromatin modifica...

journal_title：BMC genomics

authors： Zhu Z,Shi M,Hu W,Estrella H,Engebretsen J,Nichols T,Briere D,Hosea N,Los G,Rejto PA,Fanjul A

更新日期：2012-07-31 00:00:00

abstract：BACKGROUND:BCG is the most widely used vaccine of all time and remains the only licensed vaccine for use against tuberculosis in humans. BCG also protects other species such as cattle against tuberculosis, but due to its incompatibility with current tuberculin testing regimens remains unlicensed. BCG's efficacy relates...

journal_title：BMC genomics

authors： Mendum TA,Chandran A,Williams K,Vordermeier HM,Villarreal-Ramos B,Wu H,Singh A,Smith AA,Butler RE,Prasad A,Bharti N,Banerjee R,Kasibhatla SM,Bhatt A,Stewart GR,McFadden J

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Animals are thought to achieve lignocellulose digestion via symbiotic associations with gut microbes; this view leads to significant focus on bacteria and fungi for lignocellulolytic systems. The presence of biomass conversion systems hardwired into animal genomes has not yet been unequivocally demonstrated....

journal_title：BMC genomics

authors： Chang WH,Lai AG

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:Malaria pathogenesis relies on sexual gametocyte forms of the malaria parasite to be transmitted between the infected human and the mosquito host but the molecular mechanisms controlling gametocytogenesis remains poorly understood. Here we provide a high-resolution transcriptome of Plasmodium falciparum as i...

journal_title：BMC genomics

authors： van Biljon R,van Wyk R,Painter HJ,Orchard L,Reader J,Niemand J,Llinás M,Birkholtz LM

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:Meloidogyne incognita is a devastating nematode that causes significant losses in cucumber production worldwide. Although numerous studies have emphasized on the susceptible response of plants after nematode infection, the exact regulation mechanism of M. incognita-resistance in cucumber remains elusive. Ver...

journal_title：BMC genomics

authors： Wang X,Cheng C,Zhang K,Tian Z,Xu J,Yang S,Lou Q,Li J,Chen JF

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Soybean (Glycine max (L. Merr.)) resistance to any population of Heterodera glycines (I.), or Fusarium virguliforme (Akoi, O'Donnell, Homma & Lattanzi) required a functional allele at Rhg1/Rfs2. H. glycines, the soybean cyst nematode (SCN) was an ancient, endemic, pest of soybean whereas F. virguliforme caus...

journal_title：BMC genomics

authors： Srour A,Afzal AJ,Blahut-Beatty L,Hemmati N,Simmonds DH,Li W,Liu M,Town CD,Sharma H,Arelli P,Lightfoot DA

更新日期：2012-08-02 00:00:00

abstract：BACKGROUND:Fish under intensive culture conditions are exposed to a variety of acute and chronic stressors, including high rearing densities, sub-optimal water quality, and severe thermal fluctuations. Such stressors are inherent in aquaculture production and can induce physiological responses with adverse effects on t...

journal_title：BMC genomics

authors： Sánchez CC,Weber GM,Gao G,Cleveland BM,Yao J,Rexroad CE 3rd

更新日期：2011-12-21 00:00:00

abstract：BACKGROUND:Genomic inversion is one type of structural variations (SVs) and is known to play an important biological role. An established problem in sequence data analysis is calling inversions from high-throughput sequence data. It is more difficult to detect inversions because they are surrounded by duplication or ot...

journal_title：BMC genomics

authors： Wu Z,Wu Y,Gao J

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:Over the past 50,000 years, shifts in human-environmental or human-human interactions shaped genetic differences within and among human populations, including variants under positive selection. Shaped by environmental factors, such variants influence the genetics of modern health, disease, and treatment outc...

journal_title：BMC genomics

authors： Handelman SK,Seweryn M,Smith RM,Hartmann K,Wang D,Pietrzak M,Johnson AD,Kloczkowski A,Sadee W

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:RNA-Seq is now widely used as a research tool. Choices must be made whether to use paired-end (PE) or single-end (SE) sequencing, and whether to use strand-specific or non-specific (NS) library preparation kits. To date there has been no analysis of the effect of these choices on identifying differentially e...

journal_title：BMC genomics

authors： Corley SM,MacKenzie KL,Beverdam A,Roddam LF,Wilkins MR

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Sexual reproduction of scleractinians has captured the attention of researchers and the general public for decades. Although extensive ecological data has been acquired, underlying molecular and cellular mechanisms remain largely unknown. In this study, to better understand mechanisms underlying gametogenesi...

journal_title：BMC genomics

authors： Chiu YL,Shikina S,Yoshioka Y,Shinzato C,Chang CF

更新日期：2020-10-21 00:00:00

abstract：BACKGROUND:Evolution of novel protein-coding genes is the bedrock of adaptive evolution. Recently, we identified six protein-coding genes with similar signal sequence from Schistosoma japonicum egg stage mRNA using signal sequence trap (SST). To find the mechanism underlying the origination of these genes with similar ...

journal_title：BMC genomics

authors： Mbanefo EC,Chuanxin Y,Kikuchi M,Shuaibu MN,Boamah D,Kirinoki M,Hayashi N,Chigusa Y,Osada Y,Hamano S,Hirayama K

更新日期：2012-06-20 00:00:00

abstract：BACKGROUND:JWB phytoplasma is a kind of insect-transmitted and uncultivable bacterial plant pathogen causeing a destructive Jujube disease. To date, no genome information about JWB phytoplasma has been published, which hindered its characterization at genomic level. To understand its pathogenicity and ecology, the geno...

journal_title：BMC genomics

authors： Wang J,Song L,Jiao Q,Yang S,Gao R,Lu X,Zhou G

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Two-component systems (TCSs) are modular and diverse signalling pathways, involving a stimulus-responsive transfer of phosphoryl groups from transmitter to partner receiver domains. TCS gene and domain organisation are both potentially informative regarding biological function, interaction partnerships and m...

journal_title：BMC genomics

authors： Williams RH,Whitworth DE

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Identification of genes with ascending or descending monotonic expression patterns over time or stages of stem cells is an important issue in time-series microarray data analysis. We propose a method named Monotonic Feature Selector (MFSelector) based on a concept of total discriminating error (DEtotal) to i...

journal_title：BMC genomics

authors： Wang HW,Sun HJ,Chang TY,Lo HH,Cheng WC,Tseng GC,Lin CT,Chang SJ,Pal N,Chung IF

更新日期：2015-01-01 00:00:00