Characterization of SR3 reveals abundance of non-LTR retrotransposons of the RTE clade in the genome of the human blood fluke, Schistosoma mansoni.

Abstract:

BACKGROUND:It is becoming apparent that perhaps as much as half of the genome of the human blood fluke Schistosoma mansoni is constituted of mobile genetic element-related sequences. Non-long terminal repeat (LTR) retrotransposons, related to the LINE elements of mammals, comprise much of this repetitive component of the schistosome genome. Of more than 12 recognized clades of non-LTR retrotransposons, only members of the CR1, RTE, and R2 clades have been reported from the schistosome genome. RESULTS:Inspection of the nucleotide sequence of bacterial artificial chromosome number 49_J_14 from chromosome 1 of the genome of Schistosoma mansoni (GenBank AC093105) revealed the likely presence of several RTE-like retrotransposons. Among these, a new non-LTR retrotransposon designated SR3 was identified and is characterized here. Analysis of gene structure and phylogenetic analysis of both the reverse transcriptase and endonuclease domains of the mobile element indicated that SR3 represented a new family of RTE-like non-LTR retrotransposons. Remarkably, two full-length copies of SR3-like elements were present in BAC 49-J-14, and one of 3,211 bp in length appeared to be intact, indicating SR3 to be an active non-LTR retrotransposon. Both were flanked by target site duplications of 10-12 bp. Southern hybridization and bioinformatics analyses indicated the presence of numerous copies (probably >1,000) of SR3 interspersed throughout the genome of S. mansoni. Bioinformatics analyses also revealed SR3 to be transcribed in both larval and adult developmental stages of S. mansoni and to be also present in the genomes of the other major schistosome parasites of humans, Schistosoma haematobium and S. japonicum. CONCLUSION:Numerous copies of SR3, a novel non-LTR retrotransposon of the RTE clade are present in the genome of S. mansoni. Non-LTR retrotransposons of the RTE clade including SR3 appear to have been remarkably successful in colonizing, and proliferation within the schistosome genome.

journal_name

BMC Genomics

journal_title

BMC genomics

authors

Laha T,Kewgrai N,Loukas A,Brindley PJ

doi

10.1186/1471-2164-6-154

keywords:

subject

Has Abstract

pub_date

2005-11-04 00:00:00

pages

154

issn

1471-2164

pii

1471-2164-6-154

journal_volume

6

pub_type

杂志文章
  • Comparative analysis of the predicted secretomes of Rosaceae scab pathogens Venturia inaequalis and V. pirina reveals expanded effector families and putative determinants of host range.

    abstract:BACKGROUND:Fungal plant pathogens belonging to the genus Venturia cause damaging scab diseases of members of the Rosaceae. In terms of economic impact, the most important of these are V. inaequalis, which infects apple, and V. pirina, which is a pathogen of European pear. Given that Venturia fungi colonise the sub-cuti...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-3699-1

    authors: Deng CH,Plummer KM,Jones DAB,Mesarich CH,Shiller J,Taranto AP,Robinson AJ,Kastner P,Hall NE,Templeton MD,Bowen JK

    更新日期:2017-05-02 00:00:00

  • Comparative transcriptomics reveals suppressed expression of genes related to auxin and the cell cycle contributes to the resistance of cucumber against Meloidogyne incognita.

    abstract:BACKGROUND:Meloidogyne incognita is a devastating nematode that causes significant losses in cucumber production worldwide. Although numerous studies have emphasized on the susceptible response of plants after nematode infection, the exact regulation mechanism of M. incognita-resistance in cucumber remains elusive. Ver...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-4979-0

    authors: Wang X,Cheng C,Zhang K,Tian Z,Xu J,Yang S,Lou Q,Li J,Chen JF

    更新日期:2018-08-03 00:00:00

  • Comparative genomic analysis reveals occurrence of genetic recombination in virulent Cryptosporidium hominis subtypes and telomeric gene duplications in Cryptosporidium parvum.

    abstract:BACKGROUND:Cryptosporidium hominis is a dominant species for human cryptosporidiosis. Within the species, IbA10G2 is the most virulent subtype responsible for all C. hominis-associated outbreaks in Europe and Australia, and is a dominant outbreak subtype in the United States. In recent yearsIaA28R4 is becoming a major ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1517-1

    authors: Guo Y,Tang K,Rowe LA,Li N,Roellig DM,Knipe K,Frace M,Yang C,Feng Y,Xiao L

    更新日期:2015-04-18 00:00:00

  • Digital gene expression approach over multiple RNA-Seq data sets to detect neoblast transcriptional changes in Schmidtea mediterranea.

    abstract:BACKGROUND:The freshwater planarian Schmidtea mediterranea is recognised as a valuable model for research into adult stem cells and regeneration. With the advent of the high-throughput sequencing technologies, it has become feasible to undertake detailed transcriptional analysis of its unique stem cell population, the ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1533-1

    authors: Rodríguez-Esteban G,González-Sastre A,Rojo-Laguna JI,Saló E,Abril JF

    更新日期:2015-05-08 00:00:00

  • Identification of genetic loci that modulate cell proliferation in the adult rostral migratory stream using the expanded panel of BXD mice.

    abstract:BACKGROUND:Adult neurogenesis, which is the continual production of new neurons in the mature brain, demonstrates the strikingly plastic nature of the nervous system. Adult neural stem cells and their neural precursors, collectively referred to as neural progenitor cells (NPCs), are present in the subgranular zone (SGZ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-206

    authors: Poon A,Goldowitz D

    更新日期:2014-03-19 00:00:00

  • Pseudomonas aeruginosa clinical and environmental isolates constitute a single population with high phenotypic diversity.

    abstract:BACKGROUND:Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence of hospital infections that represents a threat to immune compromised patients. Genomic studies have shown that, in contrast to other pathogenic bacteria, clinical and environmental isolates do not show particular genomic differences. ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-318

    authors: Grosso-Becerra MV,Santos-Medellín C,González-Valdez A,Méndez JL,Delgado G,Morales-Espinosa R,Servín-González L,Alcaraz LD,Soberón-Chávez G

    更新日期:2014-04-28 00:00:00

  • Wheat EST resources for functional genomics of abiotic stress.

    abstract:BACKGROUND:Wheat is an excellent species to study freezing tolerance and other abiotic stresses. However, the sequence of the wheat genome has not been completely characterized due to its complexity and large size. To circumvent this obstacle and identify genes involved in cold acclimation and associated stresses, a la...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-7-149

    authors: Houde M,Belcaid M,Ouellet F,Danyluk J,Monroy AF,Dryanova A,Gulick P,Bergeron A,Laroche A,Links MG,MacCarthy L,Crosby WL,Sarhan F

    更新日期:2006-06-13 00:00:00

  • Muscle regeneration in dystrophin-deficient mdx mice studied by gene expression profiling.

    abstract:BACKGROUND:Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is lethal. In contrast, dystrophin-deficient mdx mice recover due to effective regeneration of affected muscle tissue. To characterize the molecular processes associated with regeneration, we compared gene expression levels in hin...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-6-98

    authors: Turk R,Sterrenburg E,de Meijer EJ,van Ommen GJ,den Dunnen JT,'t Hoen PA

    更新日期:2005-07-13 00:00:00

  • Characterization of the transcriptome of an ecologically important avian species, the Vinous-throated Parrotbill Paradoxornis webbianus bulomachus (Paradoxornithidae; Aves).

    abstract:BACKGROUND:Adaptive divergence driven by environmental heterogeneity has long been a fascinating topic in ecology and evolutionary biology. The study of the genetic basis of adaptive divergence has, however, been greatly hampered by a lack of genomic information. The recent development of transcriptome sequencing provi...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-149

    authors: Chu JH,Lin RC,Yeh CF,Hsu YC,Li SH

    更新日期:2012-04-24 00:00:00

  • G-spots cause incorrect expression measurement in Affymetrix microarrays.

    abstract:BACKGROUND:High Density Oligonucleotide arrays (HDONAs), such as the Affymetrix HG-U133A GeneChip, use sets of probes chosen to match specified genes, with the expectation that if a particular gene is highly expressed then all the probes in that gene's probe set will provide a consistent message signifying the gene's p...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-9-613

    authors: Upton GJ,Langdon WB,Harrison AP

    更新日期:2008-12-18 00:00:00

  • Exploring hierarchical and overlapping modular structure in the yeast protein interaction network.

    abstract:BACKGROUND:Developing effective strategies to reveal modular structures in protein interaction networks is crucial for better understanding of molecular mechanisms of underlying biological processes. In this paper, we propose a new density-based algorithm (ADHOC) for clustering vertices of a protein interaction network...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-11-S4-S17

    authors: Liu C,Li J,Zhao Y

    更新日期:2010-12-02 00:00:00

  • ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data.

    abstract:BACKGROUND:ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing) is a recently developed technique for genome-wide analysis of chromatin accessibility. Compared to earlier methods for assaying chromatin accessibility, ATAC-seq is faster and easier to perform, does not require cross-linking, has higher...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-018-4559-3

    authors: Ou J,Liu H,Yu J,Kelliher MA,Castilla LH,Lawson ND,Zhu LJ

    更新日期:2018-03-01 00:00:00

  • Culture-independent genomic characterisation of Candidatus Chlamydia sanzinia, a novel uncultivated bacterium infecting snakes.

    abstract:BACKGROUND:Recent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-3055-x

    authors: Taylor-Brown A,Bachmann NL,Borel N,Polkinghorne A

    更新日期:2016-09-05 00:00:00

  • Application of dissociation curve analysis to radiation hybrid panel marker scoring: generation of a map of river buffalo (B. bubalis) chromosome 20.

    abstract:BACKGROUND:Fluorescence of dyes bound to double-stranded PCR products has been utilized extensively in various real-time quantitative PCR applications, including post-amplification dissociation curve analysis, or differentiation of amplicon length or sequence composition. Despite the current era of whole-genome sequenc...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-9-544

    authors: Kochan KJ,Amaral ME,Agarwala R,Schäffer AA,Riggs PK

    更新日期:2008-11-17 00:00:00

  • Profile and functional analysis of small RNAs derived from Aspergillus fumigatus infected with double-stranded RNA mycoviruses.

    abstract:BACKGROUND:Mycoviruses are viruses that naturally infect and replicate in fungi. Aspergillus fumigatus, an opportunistic pathogen causing fungal lung diseases in humans and animals, was recently shown to harbour several different types of mycoviruses. A well-characterised defence against virus infection is RNA silencin...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-3773-8

    authors: Özkan S,Mohorianu I,Xu P,Dalmay T,Coutts RHA

    更新日期:2017-05-30 00:00:00

  • Hsf and Hsp gene families in Populus: genome-wide identification, organization and correlated expression during development and in stress responses.

    abstract:BACKGROUND:Heat shock proteins (Hsps) are molecular chaperones that are involved in many normal cellular processes and stress responses, and heat shock factors (Hsfs) are the transcriptional activators of Hsps. Hsfs and Hsps are widely coordinated in various biological processes. Although the roles of Hsfs and Hsps in ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1398-3

    authors: Zhang J,Liu B,Li J,Zhang L,Wang Y,Zheng H,Lu M,Chen J

    更新日期:2015-03-14 00:00:00

  • Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy.

    abstract:BACKGROUND:We have reported that doxycycline-induced over-expression of wild type prion protein (PrP) in skeletal muscles of Tg(HQK) mice is sufficient to cause a primary myopathy with no signs of peripheral neuropathy. The preferential accumulation of the truncated PrP C1 fragment was closely correlated with these myo...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-10-201

    authors: Liang J,Parchaliuk D,Medina S,Sorensen G,Landry L,Huang S,Wang M,Kong Q,Booth SA

    更新日期:2009-04-28 00:00:00

  • Complex sense-antisense architecture of TNFAIP1/POLDIP2 on 17q11.2 represents a novel transcriptional structural-functional gene module involved in breast cancer progression.

    abstract:BACKGROUND:A sense-antisense gene pair (SAGP) is a gene pair where two oppositely transcribed genes share a common nucleotide sequence region. In eukaryotic genomes, SAGPs can be organized in complex sense-antisense architectures (CSAGAs) in which at least one sense gene shares loci with two or more antisense partners....

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-11-S1-S9

    authors: Grinchuk OV,Motakis E,Kuznetsov VA

    更新日期:2010-02-10 00:00:00

  • Transcriptomic analysis of the response of Acropora millepora to hypo-osmotic stress provides insights into DMSP biosynthesis by corals.

    abstract:BACKGROUND:Dimethylsulfoniopropionate (DMSP) is a small sulphur compound which is produced in prodigious amounts in the oceans and plays a pivotal role in the marine sulfur cycle. Until recently, DMSP was believed to be synthesized exclusively by photosynthetic organisms; however we now know that corals and specific ba...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-3959-0

    authors: Aguilar C,Raina JB,Motti CA,Fôret S,Hayward DC,Lapeyre B,Bourne DG,Miller DJ

    更新日期:2017-08-14 00:00:00

  • mInDel: a high-throughput and efficient pipeline for genome-wide InDel marker development.

    abstract:BACKGROUND:Rich in genetic information and cost-effective to genotype, the Insertion-Deletion (InDel) molecular marker system is an important tool for studies in genetics, genomics and for marker-assisted breeding. Advent of next-generation sequencing (NGS) revolutionized the speed and throughput of sequence data gener...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-2614-5

    authors: Lv Y,Liu Y,Zhao H

    更新日期:2016-04-14 00:00:00

  • Transcriptome profiling in fast versus slow-growing rainbow trout across seasonal gradients.

    abstract:BACKGROUND:Circannual rhythms in vertebrates can influence a wide variety of physiological processes. Some notable examples include annual reproductive cycles and for poikilotherms, seasonal changes modulating growth. Increasing water temperature elevates growth rates in fishes, but increases in photoperiod regime can ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-016-2363-5

    authors: Danzmann RG,Kocmarek AL,Norman JD,Rexroad CE 3rd,Palti Y

    更新日期:2016-01-15 00:00:00

  • Functional genomics and microbiome profiling of the Asian longhorned beetle (Anoplophora glabripennis) reveal insights into the digestive physiology and nutritional ecology of wood feeding beetles.

    abstract:BACKGROUND:Wood-feeding beetles harbor an ecologically rich and taxonomically diverse assemblage of gut microbes that appear to promote survival in woody tissue, which is devoid of nitrogen and essential nutrients. Nevertheless, the contributions of these apparent symbionts to digestive physiology and nutritional ecolo...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-15-1096

    authors: Scully ED,Geib SM,Carlson JE,Tien M,McKenna D,Hoover K

    更新日期:2014-12-12 00:00:00

  • A wing expressed sequence tag resource for Bicyclus anynana butterflies, an evo-devo model.

    abstract:BACKGROUND:Butterfly wing color patterns are a key model for integrating evolutionary developmental biology and the study of adaptive morphological evolution. Yet, despite the biological, economical and educational value of butterflies they are still relatively under-represented in terms of available genomic resources....

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-7-130

    authors: Beldade P,Rudd S,Gruber JD,Long AD

    更新日期:2006-05-31 00:00:00

  • Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.

    abstract:BACKGROUND:In a previous genome-wide analysis of FXR binding to hepatic chromatin, we noticed that an extra nuclear receptor (NR) half-site was co-enriched close to the FXR binding IR-1 elements and we provided limited support that the monomeric LRH-1 receptor that binds to NR half-sites might function together with FX...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-51

    authors: Chong HK,Biesinger J,Seo YK,Xie X,Osborne TF

    更新日期:2012-02-01 00:00:00

  • Whole genome sequencing analysis of Plasmodium vivax using whole genome capture.

    abstract:BACKGROUND:Malaria caused by Plasmodium vivax is an experimentally neglected severe disease with a substantial burden on human health. Because of technical limitations, little is known about the biology of this important human pathogen. Whole genome analysis methods on patient-derived material are thus likely to have a...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-13-262

    authors: Bright AT,Tewhey R,Abeles S,Chuquiyauri R,Llanos-Cuentas A,Ferreira MU,Schork NJ,Vinetz JM,Winzeler EA

    更新日期:2012-06-21 00:00:00

  • Disruption of the pleiotropic gene scoC causes transcriptomic and phenotypical changes in Bacillus pumilus BA06.

    abstract:BACKGROUND:Bacillus pumilus is a Gram-positive and endospore-forming bacterium broadly existing in a variety of environmental niches. Because it produces and secrets many industrially useful enzymes, a lot of studies have been done to understand the underlying mechanisms. Among them, scoC was originally identified as a...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-019-5671-8

    authors: Han LL,Liu YC,Miao CC,Feng H

    更新日期:2019-04-30 00:00:00

  • Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum.

    abstract:BACKGROUND:It has been shown that nearly a quarter of the initial predicted gene models in the Plasmodium falciparum genome contain errors. Although there have been efforts to obtain complete cDNA sequences to correct the errors, the coverage of cDNA sequences on the predicted genes is still incomplete, and many gene m...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-12-587

    authors: López-Barragán MJ,Lemieux J,Quiñones M,Williamson KC,Molina-Cruz A,Cui K,Barillas-Mury C,Zhao K,Su XZ

    更新日期:2011-11-30 00:00:00

  • The transcriptome of the invasive eel swimbladder nematode parasite Anguillicola crassus.

    abstract:BACKGROUND:Anguillicola crassus is an economically and ecologically important parasitic nematode of eels. The native range of A. crassus is in East Asia, where it infects Anguilla japonica, the Japanese eel. A. crassus was introduced into European eels, Anguilla anguilla, 30 years ago. The parasite is more pathogenic i...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/1471-2164-14-87

    authors: Heitlinger E,Bridgett S,Montazam A,Taraschewski H,Blaxter M

    更新日期:2013-02-08 00:00:00

  • Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns.

    abstract:BACKGROUND:Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with a higher than normal risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disea...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-015-1295-9

    authors: Riedmann C,Ma Y,Melikishvili M,Godfrey SG,Zhang Z,Chen KC,Rouchka EC,Fondufe-Mittendorf YN

    更新日期:2015-03-19 00:00:00

  • DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content.

    abstract:BACKGROUND:Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component of many human food products. However, compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we ...

    journal_title:BMC genomics

    pub_type: 杂志文章

    doi:10.1186/s12864-017-4320-3

    authors: Lopdell TJ,Tiplady K,Struchalin M,Johnson TJJ,Keehan M,Sherlock R,Couldrey C,Davis SR,Snell RG,Spelman RJ,Littlejohn MD

    更新日期:2017-12-15 00:00:00