Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR.

abstract：BACKGROUND:Tandem mass spectrometry allows biologists to identify and quantify protein samples in the form of digested peptide sequences. When performing peptide identification, spectral library search is more sensitive than traditional database search but is limited to peptides that have been previously identified. An...

journal_title：BMC genomics

authors： Lin YM,Chen CT,Chang JM

更新日期：2019-12-24 00:00:00

abstract：BACKGROUND:Rainbow trout is a significant fish farming species under temperate climates. Female reproduction traits play an important role in the economy of breeding companies with the sale of fertilized eggs. The objectives of this study are threefold: to estimate the genetic parameters of female reproduction traits, ...

journal_title：BMC genomics

authors： D'Ambrosio J,Morvezen R,Brard-Fudulea S,Bestin A,Acin Perez A,Guéméné D,Poncet C,Haffray P,Dupont-Nivet M,Phocas F

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:The superior temporal gyrus (STG), which encompasses the primary auditory cortex, is believed to be a major anatomical substrate for speech, language and communication. The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, a...

journal_title：BMC genomics

authors： Bowden NA,Scott RJ,Tooney PA

更新日期：2008-04-29 00:00:00

abstract：BACKGROUND:Galileo is one of three members of the P superfamily of DNA transposons. It was originally discovered in Drosophila buzzatii, in which three segregating chromosomal inversions were shown to have been generated by ectopic recombination between Galileo copies. Subsequently, Galileo was identified in six of 12 ...

journal_title：BMC genomics

authors： Gonçalves JW,Valiati VH,Delprat A,Valente VL,Ruiz A

更新日期：2014-09-13 00:00:00

abstract：BACKGROUND:The genomic organisation of the Major Histocompatibility Complex (MHC) varies greatly between different vertebrates. In mammals, the classical MHC consists of a large number of linked genes (e.g. greater than 200 in humans) with predominantly immune function. In some birds, it consists of only a small number...

journal_title：BMC genomics

authors： Sambrook JG,Figueroa F,Beck S

更新日期：2005-11-04 00:00:00

abstract：BACKGROUND:Small RNA (sRNA) sequences are known to have a broad impact on gene regulation by various mechanisms. Their performance for the prediction of hybrid traits has not yet been analyzed. Our objective was to analyze the relation of parental sRNA expression with the performance of their hybrids, to develop a sRNA...

journal_title：BMC genomics

authors： Seifert F,Thiemann A,Schrag TA,Rybka D,Melchinger AE,Frisch M,Scholten S

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:Hemolymph plays key roles in honey bee molecule transport, immune defense, and in monitoring the physiological condition. There is a lack of knowledge regarding how the proteome achieves these biological missions for both the western and eastern honey bees (Apis mellifera and Apis cerana). A time-resolved pr...

journal_title：BMC genomics

authors： Feng M,Ramadan H,Han B,Fang Y,Li J

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:Glutamine is a major amino donor for the synthesis of amino acids, nucleotides, and other nitrogen-containing compounds in all organisms. In addition to its role in nutrition and metabolism, glutamine can also function as a signaling molecule in bacteria, yeast, and humans. By contrast, the functions of glut...

journal_title：BMC genomics

authors： Kan CC,Chung TY,Juo YA,Hsieh MH

更新日期：2015-09-25 00:00:00

abstract：BACKGROUND:Many biological systems respond to the presence or absence of gravity. Since experiments performed in space are expensive and can only be undertaken infrequently, Earth-based simulation techniques are used to investigate the biological response to weightlessness. A high gradient magnetic field can be used to...

journal_title：BMC genomics

authors： Herranz R,Larkin OJ,Dijkstra CE,Hill RJ,Anthony P,Davey MR,Eaves L,van Loon JJ,Medina FJ,Marco R

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Ubiquitination is an important post-translational modification involved in diverse biological processes. Therefore, genomewide representation of the ubiquitination system for a species is important. DESCRIPTION:SCUD is a web-based database for the ubiquitination system in Saccharomyces cerevisiae (Baker's y...

journal_title：BMC genomics

authors： Lee WC,Lee M,Jung JW,Kim KP,Kim D

更新日期：2008-09-24 00:00:00

abstract：BACKGROUND:miRNAs are small, non-coding RNA molecules that mainly act as negative regulators of target gene messages. Due to their regulatory functions, they have lately been implicated in several diseases, including malignancies. Roughly half of known miRNA genes are located within previously annotated protein-coding ...

journal_title：BMC genomics

authors： Hinske LC,Galante PA,Kuo WP,Ohno-Machado L

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT). The method is built on two information-theoretic metrics, the k-way interaction inf...

journal_title：BMC genomics

authors： Chanda P,Sucheston L,Liu S,Zhang A,Ramanathan M

更新日期：2009-11-04 00:00:00

abstract：BACKGROUND:Obtaining complete gene structures is one major goal of genome assembly. Some gene regions are fragmented in low quality and high-quality assemblies. Therefore, new approaches are needed to recover gene regions. Genomes are widely transcribed, generating messenger and non-coding RNAs. These widespread transc...

journal_title：BMC genomics

authors： Zhu BH,Xiao J,Xue W,Xu GC,Sun MY,Li JT

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Whole exome sequencing studies identify hundreds to thousands of rare protein coding variants of ambiguous significance for human health. Computational tools are needed to accelerate the identification of specific variants and genes that contribute to human disease. RESULTS:We have developed the Variant Eff...

journal_title：BMC genomics

authors： Carter H,Douville C,Stenson PD,Cooper DN,Karchin R

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Microsatellites are widely used for many genetic studies. In contrast to single nucleotide polymorphism (SNP) and genotyping-by-sequencing methods, they are readily typed in samples of low DNA quality/concentration (e.g. museum/non-invasive samples), and enable the quick, cheap identification of species, hyb...

journal_title：BMC genomics

authors： Dawson DA,Ball AD,Spurgin LG,Martín-Gálvez D,Stewart IR,Horsburgh GJ,Potter J,Molina-Morales M,Bicknell AW,Preston SA,Ekblom R,Slate J,Burke T

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:Drought is a lifestyle disease. Plant metabolomics has been exercised for understanding the fine-tuning of the potential pathways to surmount the adverse effects of drought stress. A broad spectrum of morphological and metabolic responses from seven Triticeae species including wild types with different droug...

journal_title：BMC genomics

authors： Ullah N,Yüce M,Neslihan Öztürk Gökçe Z,Budak H

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:The objective of this research was to investigate the reproducibility of cross-species microarray hybridisation. Comparisons between same- and cross-species hybridisations were also made. Nine hybridisations between a single pig skeletal muscle RNA sample and three human cDNA nylon microarrays were completed...

journal_title：BMC genomics

authors： Moody DE,Zou Z,McIntyre L

更新日期：2002-09-27 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression mainly through translational repression of target mRNA molecules. More than 2700 human miRNAs have been identified and some are known to be associated with disease phenotypes and to display tissue-specific patterns of expression. ME...

journal_title：BMC genomics

authors： Wake C,Labadorf A,Dumitriu A,Hoss AG,Bregu J,Albrecht KH,DeStefano AL,Myers RH

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Enterohemorrhagic Escherichia coli (EHEC) are zoonotic agents associated with outbreaks worldwide. Growth of EHEC strains in ground beef could be inhibited by background microbiota that is present initially at levels greater than that of the pathogen E. coli. However, how the microbiota outcompetes the patho...

journal_title：BMC genomics

authors： Galia W,Leriche F,Cruveiller S,Garnier C,Navratil V,Dubost A,Blanquet-Diot S,Thevenot-Sergentet D

更新日期：2017-08-03 00:00:00

abstract：BACKGROUND:It is believed that the main factors of low prenatal growth in mammals are genetic and environmental. We used isogenic mice maintained in standard conditions to analyze how natural non-genetic microsomia (low birth weight) is produced in inbred mice and its long term effect on health. To better understand th...

journal_title：BMC genomics

authors： Miranda A,López-Cardona AP,Laguna-Barraza R,Calle A,López-Vidriero I,Pintado B,Gutiérrez-Adán A

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Although primarily known as the site of ribosome subunit production, the nucleolus is involved in numerous and diverse cellular processes. Recent large-scale proteomics projects have identified thousands of human proteins that associate with the nucleolus. However, in most cases, we know neither the fraction...

journal_title：BMC genomics

authors： Scott MS,Boisvert FM,Lamond AI,Barton GJ

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Arrhythmogenic cardiomyopathy (ACM) is a genetic autosomal disease characterized by abnormal cell-cell adhesion, cardiomyocyte death, progressive fibro-adipose replacement of the myocardium, arrhythmias and sudden death. Several different cell types contribute to the pathogenesis of ACM, including, as recent...

journal_title：BMC genomics

authors： Rainer J,Meraviglia V,Blankenburg H,Piubelli C,Pramstaller PP,Paolin A,Cogliati E,Pompilio G,Sommariva E,Domingues FS,Rossini A

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Next-generation sequencing is providing researchers with a relatively fast and affordable option for developing genomic resources for organisms that are not among the traditional genetic models. Here we present a de novo assembly of the guppy (Poecilia reticulata) transcriptome using 454 sequence reads, and ...

journal_title：BMC genomics

authors： Fraser BA,Weadick CJ,Janowitz I,Rodd FH,Hughes KA

更新日期：2011-04-20 00:00:00

abstract：BACKGROUND:Gene expression analysis by reverse transcription quantitative PCR (qPCR) is the most widely used method for analyzing the expression of a moderate number of genes and also for the validation of microarray results. Several issues are crucial for a successful qPCR study, particularly the selection of internal...

journal_title：BMC genomics

authors： Robledo D,Hernández-Urcera J,Cal RM,Pardo BG,Sánchez L,Martínez P,Viñas A

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:The European spruce bark beetle, Ips typographus, and the North American mountain pine beetle, Dendroctonus ponderosae (Coleoptera: Curculionidae: Scolytinae), are severe pests of coniferous forests. Both bark beetle species utilize aggregation pheromones to coordinate mass-attacks on host trees, while odora...

journal_title：BMC genomics

authors： Andersson MN,Grosse-Wilde E,Keeling CI,Bengtsson JM,Yuen MM,Li M,Hillbur Y,Bohlmann J,Hansson BS,Schlyter F

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:The complex genome of rapeseed (Brassica napus) is not well understood despite the economic importance of the species. Good knowledge of sequence variation is needed for genetics approaches and breeding purposes. We used a diversity set of B. napus representing eight different germplasm types to sequence gen...

journal_title：BMC genomics

authors： Bus A,Hecht J,Huettel B,Reinhardt R,Stich B

更新日期：2012-06-24 00:00:00

abstract：BACKGROUND:Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct repeats of RGKTCA motifs separated by 1 to 5 bp (DR1-DR5). Although many known such response elements ...

journal_title：BMC genomics

authors： Laperriere D,Wang TT,White JH,Mader S

更新日期：2007-01-19 00:00:00

abstract：BACKGROUND:The Brassicaceae family is an exemplary model for studying plant polyploidy. The Brassicaceae knowledge-base includes the well-annotated Arabidopsis thaliana reference sequence; well-established evidence for three rounds of whole genome duplication (WGD); and the conservation of genomic structure, with 24 co...

journal_title：BMC genomics

authors： Kim J,Lee J,Choi JP,Park I,Yang K,Kim MK,Lee YH,Nou IS,Kim DS,Min SR,Park SU,Kim H

更新日期：2014-07-18 00:00:00

abstract：BACKGROUND:RNA amplification is necessary for profiling gene expression from small tissue samples. Previous studies have shown that the T7 based amplification techniques are reproducible but may distort the true abundance of targets. However, the consequences of such distortions on the ability to detect biological vari...

journal_title：BMC genomics

authors： Diboun I,Wernisch L,Orengo CA,Koltzenburg M

更新日期：2006-10-09 00:00:00

abstract：BACKGROUND:Heat shock proteins (Hsps) are molecular chaperones that are involved in many normal cellular processes and stress responses, and heat shock factors (Hsfs) are the transcriptional activators of Hsps. Hsfs and Hsps are widely coordinated in various biological processes. Although the roles of Hsfs and Hsps in ...

journal_title：BMC genomics

authors： Zhang J,Liu B,Li J,Zhang L,Wang Y,Zheng H,Lu M,Chen J

更新日期：2015-03-14 00:00:00