Novel microRNA discovery using small RNA sequencing in post-mortem human brain.

abstract：BACKGROUND:Rapeseed (Brassica napus) is an important oil seed crop in the Brassicaceae family. Chemical induced male sterility (CIMS) is one of the widely used method to produce the hybrids in B. napus. Identification of the key genes and pathways that involved in CIMS were important to understand the underlying molecu...

journal_title：BMC genomics

authors： Ning L,Lin Z,Gu J,Gan L,Li Y,Wang H,Miao L,Zhang L,Wang B,Li M

更新日期：2018-11-07 00:00:00

abstract：BACKGROUND:Simple sequence repeats (SSRs) have become widely used as molecular markers in plant genetic studies due to their abundance, high allelic variation at each locus and simplicity to analyze using conventional PCR amplification. To study plants with unknown genome sequence, SSR markers from Expressed Sequence T...

journal_title：BMC genomics

authors： Ponyared P,Ponsawat J,Tongsima S,Seresangtakul P,Akkasaeng C,Tantisuwichwong N

更新日期：2016-12-22 00:00:00

abstract：BACKGROUND:The MHC and KIR loci are clinically relevant regions of the genome. Typing the sequence of these loci has a wide range of applications including organ transplantation, drug discovery, pharmacogenomics and furthering fundamental research in immune genetics. Rapid advances in biochemical and next-generation se...

journal_title：BMC genomics

authors： Selvaraj S,Schmitt AD,Dixon JR,Ren B

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:Poxviruses constitute one of the largest and most complex animal virus families known. The notorious smallpox disease has been eradicated and the virus contained, but its simian sister, monkeypox is an emerging, untreatable infectious disease, killing 1 to 10 % of its human victims. In the case of poxviruses...

journal_title：BMC genomics

authors： Zhao K,Wohlhueter RM,Li Y

更新日期：2016-08-31 00:00:00

abstract：BACKGROUND:Deep sequencing is a powerful tool for assessing viral genetic diversity. Such experiments harness the high coverage afforded by next generation sequencing protocols by treating sequencing reads as a population sample. Distinguishing true single nucleotide variants (SNVs) from sequencing errors remains chall...

journal_title：BMC genomics

authors： McElroy K,Zagordi O,Bull R,Luciani F,Beerenwinkel N

更新日期：2013-07-24 00:00:00

abstract：BACKGROUND:Copy neutral loss of heterozygosity (CN-LOH) refers to a special case of LOH occurring without any resulting loss in copy number. These alterations is sometimes seen in tumors as a way to inactivate a tumor suppressor gene and have been found to be important in several types of cancer. RESULTS:We have used ...

journal_title：BMC genomics

authors： Kryh H,Carén H,Erichsen J,Sjöberg RM,Abrahamsson J,Kogner P,Martinsson T

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:Ammonia is one of the most common toxicological environment factors affecting shrimp health. Although ammonia tolerance in shrimp is closely related to successful industrial production, few genetic studies of this trait are available. RESULTS:In this study, we constructed a high-density genetic map of the P...

journal_title：BMC genomics

authors： Zeng D,Yang C,Li Q,Zhu W,Chen X,Peng M,Chen X,Lin Y,Wang H,Liu H,Liang J,Liu Q,Zhao Y

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Small untranslated RNAs (sRNAs) seem to be far more abundant than previously believed. The number of sRNAs confirmed in E. coli through various approaches is above 70, with several hundred more sRNA candidate genes under biological validation. Although the total number of sRNAs in any one species is still un...

journal_title：BMC genomics

authors： Ulvé VM,Sevin EW,Chéron A,Barloy-Hubler F

更新日期：2007-12-19 00:00:00

abstract：BACKGROUND:Abnormalities of pre-mRNA splicing are increasingly recognized as an important mechanism through which gene mutations cause disease. However, apart from the mutations in the donor and acceptor sites, the effects on splicing of other sequence variations are difficult to predict. Loosely defined exonic and int...

journal_title：BMC genomics

authors： Lastella P,Surdo NC,Resta N,Guanti G,Stella A

更新日期：2006-09-22 00:00:00

abstract：BACKGROUND:Pre-harvest sprouting frequently occurs in Triticum aestivum (wheat) and Hordeum vulgare (barley) at the end of the maturity period due to high rainfall, particularly in Asian monsoon areas. Seed dormancy is a major mechanism preventing pre-harvest sprouting in these crops. RESULTS:We identified orthologous...

journal_title：BMC genomics

authors： Onishi K,Yamane M,Yamaji N,Tokui M,Kanamori H,Wu J,Komatsuda T,Sato K

更新日期：2017-06-29 00:00:00

abstract：BACKGROUND:Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with a higher than normal risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disea...

journal_title：BMC genomics

authors： Riedmann C,Ma Y,Melikishvili M,Godfrey SG,Zhang Z,Chen KC,Rouchka EC,Fondufe-Mittendorf YN

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Gene expression variation is a key underlying factor influencing phenotypic variation, and can occur via cis- or trans-regulation. To understand the role of cis- and trans-regulatory variation on population divergence in chicken, we developed reciprocal crosses of two chicken breeds, White Leghorn and Cornis...

journal_title：BMC genomics

authors： Wang Q,Jia Y,Wang Y,Jiang Z,Zhou X,Zhang Z,Nie C,Li J,Yang N,Qu L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:Panax notoginseng (Burk) F.H. Chen is important medicinal plant of the Araliacease family. Triterpene saponins are the bioactive constituents in P. notoginseng. However, available genomic information regarding this plant is limited. Moreover, details of triterpene saponin biosynthesis in the Panax species ar...

journal_title：BMC genomics

authors： Luo H,Sun C,Sun Y,Wu Q,Li Y,Song J,Niu Y,Cheng X,Xu H,Li C,Liu J,Steinmetz A,Chen S

更新日期：2011-12-23 00:00:00

abstract：BACKGROUND:The small airway epithelium (SAE), the cell population that covers the human airway surface from the 6th generation of airway branching to the alveoli, is the major site of lung disease caused by smoking. The focus of this study is to provide quantitative assessment of the SAE transcriptome in the resting st...

journal_title：BMC genomics

authors： Hackett NR,Butler MW,Shaykhiev R,Salit J,Omberg L,Rodriguez-Flores JL,Mezey JG,Strulovici-Barel Y,Wang G,Didon L,Crystal RG

更新日期：2012-02-29 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in young children. The degree of disease severity is determined by the host response to infection. Lung macrophages play an important early role in the host response to infection and we have used a systems-based appr...

journal_title：BMC genomics

authors： Ravi LI,Li L,Sutejo R,Chen H,Wong PS,Tan BH,Sugrue RJ

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Obesity affects quality of life and life expectancy and is associated with cardiovascular disorders, cancer, diabetes, reproductive disorders in women, prostate diseases in men, and congenital anomalies in children. The use of single nucleotide polymorphism (SNP) markers of diseases and drug responses (i.e.,...

journal_title：BMC genomics

authors： Arkova OV,Ponomarenko MP,Rasskazov DA,Drachkova IA,Arshinova TV,Ponomarenko PM,Savinkova LK,Kolchanov NA

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cotton (Gossypium spp.) is the most important natural fiber crop worldwide, and cottonseed oil is its most important byproduct. Phospholipid: diacylglycerol acyltransferase (PDAT) is important in TAG biosynthesis, as it catalyzes the transfer of a fatty acyl moiety from the sn-2 position of a phospholipid to...

journal_title：BMC genomics

authors： Zang X,Geng X,Ma L,Wang N,Pei W,Wu M,Zhang J,Yu J

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:Understanding the underlying genetic structure of human populations is of fundamental interest to both biological and social sciences. Advances in high-throughput genotyping technology have markedly improved our understanding of global patterns of human genetic variation. The most widely used methods for col...

journal_title：BMC genomics

authors： Maróti Z,Boldogkői Z,Tombácz D,Snyder M,Kalmár T

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Copy number variants (CNVs) have been shown to increase risk for physical anomalies, developmental, psychiatric and medical disorders. Some of them have been associated with changes in weight, height, and other physical traits. As most studies have been performed on children and young people, these effects o...

journal_title：BMC genomics

authors： Owen D,Bracher-Smith M,Kendall KM,Rees E,Einon M,Escott-Price V,Owen MJ,O'Donovan MC,Kirov G

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is a...

journal_title：BMC genomics

authors： Staley LA,Ebbert MT,Parker S,Bailey M,Alzheimer’s Disease Neuroimaging Initiative.,Ridge PG,Goate AM,Kauwe JS

更新日期：2016-06-29 00:00:00

abstract：BACKGROUND:The growth and development of the posterior silk gland and the biosynthesis of the silk core protein at the fifth larval instar stage of Bombyx mori are of paramount importance for silk production. RESULTS:Here, aided by next-generation sequencing and microarry assay, we profile 1,229 microRNAs (miRNAs), in...

journal_title：BMC genomics

authors： Li J,Cai Y,Ye L,Wang S,Che J,You Z,Yu J,Zhong B

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Metagenomic sequencing is a powerful technology for studying the mixture of microbes or the microbiomes on human and in the environment. One basic task of analyzing metagenomic data is to identify the component genomes in the community. This task is challenging due to the complexity of microbiome composition...

journal_title：BMC genomics

authors： Hua K,Zhang X

更新日期：2019-04-04 00:00:00

abstract：BACKGROUND:Senegalese sole (Solea senegalensis) and common sole (S. solea) are two economically and evolutionary important flatfish species both in fisheries and aquaculture. Although some genomic resources and tools were recently described in these species, further sequencing efforts are required to establish a comple...

journal_title：BMC genomics

authors： Benzekri H,Armesto P,Cousin X,Rovira M,Crespo D,Merlo MA,Mazurais D,Bautista R,Guerrero-Fernández D,Fernandez-Pozo N,Ponce M,Infante C,Zambonino JL,Nidelet S,Gut M,Rebordinos L,Planas JV,Bégout ML,Claros MG,Manchado

更新日期：2014-11-03 00:00:00

abstract：BACKGROUND:Transcriptomics in non-model plant systems has recently reached a point where the examination of nuclear genome-wide patterns in understudied groups is an achievable reality. This progress is especially notable in evolutionary studies of ferns, for which molecular resources to date have been derived primaril...

journal_title：BMC genomics

authors： Grusz AL,Rothfels CJ,Schuettpelz E

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Despite the recent identification of several prognostic gene signatures, the lack of common genes among experimental cohorts has posed a considerable challenge in uncovering the molecular basis underlying hepatocellular carcinoma (HCC) recurrence for application in clinical purposes. To overcome the limitati...

journal_title：BMC genomics

authors： Kim BY,Choi DW,Woo SR,Park ER,Lee JG,Kim SH,Koo I,Park SH,Han CJ,Kim SB,Yeom YI,Yang SJ,Yu A,Lee JW,Jang JJ,Cho MH,Jeon WK,Park YN,Suh KS,Lee KH

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:One member of the W family of human endogenous retroviruses (HERV) appears to have been functionally adopted by the human host. Nevertheless, a highly diversified and regulated transcription from a range of HERV-W elements has been observed in human tissues and cells. Aberrant expression of members of this f...

journal_title：BMC genomics

authors： Li F,Nellåker C,Yolken RH,Karlsson H

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:The milk fat profile of the Danish Holstein (DH) and Danish Jersey (DJ) show clear differences. Identification of the genomic regions, genes and biological pathways underlying the milk fat biosynthesis will improve the understanding of the biology underlying bovine milk fat production and may provide new pos...

journal_title：BMC genomics

authors： Buitenhuis B,Janss LL,Poulsen NA,Larsen LB,Larsen MK,Sørensen P

更新日期：2014-12-15 00:00:00

abstract：BACKGROUND:Bixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L. An enzymatic pathway for bixin biosynthesis was inferred from homology of putative proteins encoded by differentially expressed seed cDNAs. Some activities we...

journal_title：BMC genomics

authors： Cárdenas-Conejo Y,Carballo-Uicab V,Lieberman M,Aguilar-Espinosa M,Comai L,Rivera-Madrid R

更新日期：2015-10-28 00:00:00

abstract：BACKGROUND:In clinical and basic research custom panels for transcript profiling are gaining importance because only project specific informative genes are interrogated. This approach reduces costs and complexity of data analysis and allows multiplexing of samples. Polymerase-chain-reaction (PCR) based TaqMan assays ha...

journal_title：BMC genomics

authors： Zhang JD,Schindler T,Küng E,Ebeling M,Certa U

更新日期：2014-07-05 00:00:00

abstract：BACKGROUND:Annotating mammalian genomes for noncoding RNAs (ncRNAs) is nontrivial since far from all ncRNAs are known and the computational models are resource demanding. Currently, the human genome holds the best mammalian ncRNA annotation, a result of numerous efforts by several groups. However, a more direct strateg...

journal_title：BMC genomics

authors： Anthon C,Tafer H,Havgaard JH,Thomsen B,Hedegaard J,Seemann SE,Pundhir S,Kehr S,Bartschat S,Nielsen M,Nielsen RO,Fredholm M,Stadler PF,Gorodkin J

更新日期：2014-06-10 00:00:00