Single nucleotide polymorphism discovery from expressed sequence tags in the waterflea Daphnia magna.

abstract：BACKGROUND:Wheat is the most important staple crop in Afghanistan and accounts for the main part of cereal production. However, wheat production has been unstable during the last decades and the country depends on seed imports. Wheat research in Afghanistan has emphasized releases of new, high-yielding and disease resi...

journal_title：BMC genomics

authors： Dreisigacker S,Sharma RK,Huttner E,Karimov A,Obaidi MQ,Singh PK,Sansaloni C,Shrestha R,Sonder K,Braun HJ

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Genomic studies such as genome-wide association and genomic selection require genome-wide genotype data. All existing technologies used to create these data result in missing genotypes, which are often then inferred using genotype imputation software. However, existing imputation methods most often make use ...

journal_title：BMC genomics

authors： Money D,Migicovsky Z,Gardner K,Myles S

更新日期：2017-07-10 00:00:00

abstract：BACKGROUND:Matrix attachment regions (MAR) are the sites on genomic DNA that interact with the nuclear matrix. There is increasing evidence for the involvement of MAR in regulation of gene expression. The unsuitability of experimental detection of MAR for genome-wide analyses has led to the development of computational...

journal_title：BMC genomics

authors： Anthony A,Blaxter M

更新日期：2007-11-15 00:00:00

abstract：BACKGROUND:Horseradish peroxidases (HRPs) from Armoracia rusticana have long been utilized as reporters in various diagnostic assays and histochemical stainings. Regardless of their increasing importance in the field of life sciences and suggested uses in medical applications, chemical synthesis and other industrial ap...

journal_title：BMC genomics

authors： Näätsaari L,Krainer FW,Schubert M,Glieder A,Thallinger GG

更新日期：2014-03-24 00:00:00

abstract：BACKGROUND:Bacillus pumilus is a Gram-positive and endospore-forming bacterium broadly existing in a variety of environmental niches. Because it produces and secrets many industrially useful enzymes, a lot of studies have been done to understand the underlying mechanisms. Among them, scoC was originally identified as a...

journal_title：BMC genomics

authors： Han LL,Liu YC,Miao CC,Feng H

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Although profiling of RNA in single cells has broadened our understanding of development, cancer biology and mechanisms of disease dissemination, it requires the development of reliable and flexible methods. Here we demonstrate that the EpiStem RNA-Amp™ methodology reproducibly generates microgram amounts of...

journal_title：BMC genomics

authors： Rothwell DG,Li Y,Ayub M,Tate C,Newton G,Hey Y,Carter L,Faulkner S,Moro M,Pepper S,Miller C,Blackhall F,Bertolini G,Roz L,Dive C,Brady G

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:The Bacillus cereus sensu lato group currently includes seven species (B. cereus, B. anthracis, B. mycoides, B. pseudomycoides, B. thuringiensis, B. weihenstephanensis and B. cytotoxicus) that recent phylogenetic and phylogenomic analyses suggest are likely a single species, despite their varied phenotypes. ...

journal_title：BMC genomics

authors： Scott E 2nd,Dyer DW

更新日期：2012-10-22 00:00:00

abstract：BACKGROUND:Pyrethroid resistance in Anopheles funestus populations has led to an increase in malaria transmission in southern Africa. Resistance has been attributed to elevated activities of cytochrome P450s but the molecular basis underlying this metabolic resistance is unknown. Microsatellite and SNP markers were use...

journal_title：BMC genomics

authors： Wondji CS,Morgan J,Coetzee M,Hunt RH,Steen K,Black WC 4th,Hemingway J,Ranson H

更新日期：2007-01-29 00:00:00

abstract：BACKGROUND:Host genetics is one of several factors known to shape human gut microbiome composition, however, the physiological processes underlying the heritability are largely unknown. Inter-individual differences in host factors secreted into the gut lumen may lead to variation in microbiome composition. One such fac...

journal_title：BMC genomics

authors： Davenport ER,Goodrich JK,Bell JT,Spector TD,Ley RE,Clark AG

更新日期：2016-11-21 00:00:00

abstract：BACKGROUND:Calcium-dependent protein kinase (CPK) is one of the main Ca2+ combined protein kinase that play significant roles in plant growth, development and response to multiple stresses. Despite an important member of the stress responsive gene family, little is known about the evolutionary history and expression pa...

journal_title：BMC genomics

authors： Zhang M,Liu Y,He Q,Chai M,Huang Y,Chen F,Wang X,Liu Y,Cai H,Qin Y

更新日期：2020-01-23 00:00:00

abstract：BACKGROUND:The sequence of the pathogen Mycobacterium tuberculosis (Mtb) strain H37Rv has been available for over a decade, but the biology of the pathogen remains poorly understood. Genome sequences from other Mtb strains and closely related bacteria present an opportunity to apply the power of comparative genomics to...

journal_title：BMC genomics

authors： McGuire AM,Weiner B,Park ST,Wapinski I,Raman S,Dolganov G,Peterson M,Riley R,Zucker J,Abeel T,White J,Sisk P,Stolte C,Koehrsen M,Yamamoto RT,Iacobelli-Martinez M,Kidd MJ,Maer AM,Schoolnik GK,Regev A,Galagan J

更新日期：2012-03-28 00:00:00

abstract：BACKGROUND:Aquaculture is the quickest growing sector in agriculture. However, QTL for important traits have been only identified in a few aquaculture species. We conducted QTL mapping for growth traits in an Asian seabass F(2) family with 359 individuals using 123 microsatellites and 22 SNPs, and performed association...

journal_title：BMC genomics

authors： Xia JH,Lin G,He X,Liu P,Liu F,Sun F,Tu R,Yue GH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:The Zap1 transcription factor is a central player in the response of yeast to changes in zinc status. We previously used transcriptome profiling with DNA microarrays to identify 46 potential Zap1 target genes in the yeast genome. In this new study, we used complementary methods to identify additional Zap1 ta...

journal_title：BMC genomics

authors： Wu CY,Bird AJ,Chung LM,Newton MA,Winge DR,Eide DJ

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics variant detections are prone...

journal_title：BMC genomics

authors： Bhagwate AV,Liu Y,Winham SJ,McDonough SJ,Stallings-Mann ML,Heinzen EP,Davila JI,Vierkant RA,Hoskin TL,Frost M,Carter JM,Radisky DC,Cunningham JM,Degnim AC,Wang C

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:High throughput genotyping of single nucleotide polymorphisms (SNPs) for genome-wide association requires technologies for generating millions of genotypes with relative ease but also at a reasonable cost and with high accuracy. In this work, we have developed a theoretical approach to estimate allele freque...

journal_title：BMC genomics

authors： Yin BC,Li H,Ye BC

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:Quantitative trait locus (QTL) studies show that variation in salinity tolerance in Arctic charr and rainbow trout has a genetic basis, even though both these species have low to moderate salinity tolerance capacities. QTL were observed to localize to homologous linkage group segments within putative chromos...

journal_title：BMC genomics

authors： Norman JD,Robinson M,Glebe B,Ferguson MM,Danzmann RG

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:Many tools exist to predict structural variants (SVs), utilizing a variety of algorithms. However, they have largely been developed and tested on human germline or somatic (e.g. cancer) variation. It seems appropriate to exploit this wealth of technology available for humans also for other species. Objective...

journal_title：BMC genomics

authors： Leung WY,Marschall T,Paudel Y,Falquet L,Mei H,Schönhuth A,Maoz Moss TY

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence of hospital infections that represents a threat to immune compromised patients. Genomic studies have shown that, in contrast to other pathogenic bacteria, clinical and environmental isolates do not show particular genomic differences. ...

journal_title：BMC genomics

authors： Grosso-Becerra MV,Santos-Medellín C,González-Valdez A,Méndez JL,Delgado G,Morales-Espinosa R,Servín-González L,Alcaraz LD,Soberón-Chávez G

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:The unfolded protein response (UPR) is a network of intracellular signaling pathways that supports the ability of the secretory pathway to maintain a balance between the load of proteins entering the endoplasmic reticulum (ER) and the protein folding capacity of the ER lumen. Current evidence indicates that ...

journal_title：BMC genomics

authors： Krishnan K,Ren Z,Losada L,Nierman WC,Lu LJ,Askew DS

更新日期：2014-02-25 00:00:00

abstract：BACKGROUND:This paper presents a retrospective statistical study on the newly-released data set by the Stanley Neuropathology Consortium on gene expression in bipolar disorder and schizophrenia. This data set contains gene expression data as well as limited demographic and clinical data for each subject. Previous studi...

journal_title：BMC genomics

authors： Struyf J,Dobrin S,Page D

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:Obtaining reliable and reproducible two-color microarray gene expression data is critically important for understanding the biological significance of perturbations made on a cellular system. Microarray design, RNA preparation and labeling, hybridization conditions and data acquisition and analysis are varia...

journal_title：BMC genomics

authors： Novoradovskaya N,Whitfield ML,Basehore LS,Novoradovsky A,Pesich R,Usary J,Karaca M,Wong WK,Aprelikova O,Fero M,Perou CM,Botstein D,Braman J

更新日期：2004-03-09 00:00:00

abstract：BACKGROUND:Housekeeping (HK) genes are ubiquitously expressed in all tissue/cell types and constitute a basal transcriptome for the maintenance of basic cellular functions. Partitioning transcriptomes into HK and tissue-specific (TS) genes relatively is fundamental for studying gene expression and cellular differentiat...

journal_title：BMC genomics

authors： Zhu J,He F,Song S,Wang J,Yu J

更新日期：2008-04-16 00:00:00

abstract：MOTIVATION:With the rapid growth rate of newly sequenced genomes, species tree inference from multiple genes has become a basic bioinformatics task in comparative and evolutionary biology. However, accurate species tree estimation is difficult in the presence of gene tree discordance, which is often due to incomplete l...

journal_title：BMC genomics

authors： Bayzid MS,Hunt T,Warnow T

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression implicated in multiple cellular processes. Cyclic stretch of alveoli is characteristic of mechanical ventilation, and is postulated to be partly responsible for the lung injury and inflammation in ventilator-induced lung injury. We pro...

journal_title：BMC genomics

authors： Yehya N,Yerrapureddy A,Tobias J,Margulies SS

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:Artificial insemination and genetic selection are major factors contributing to population stratification in dairy cattle. In this study, we analyzed the effect of sample stratification and the effect of stratification correction on results of a dairy genome-wide association study (GWAS). Three methods for s...

journal_title：BMC genomics

authors： Ma L,Wiggans GR,Wang S,Sonstegard TS,Yang J,Crooker BA,Cole JB,Van Tassell CP,Lawlor TJ,Da Y

更新日期：2012-10-06 00:00:00

abstract：BACKGROUND:It is well understood that distinct communities of bacteria are present at different sites of the body, and that changes in the structure of these communities have strong implications for human health. Yet, challenges remain in understanding the complex interconnections between the bacterial taxa within thes...

journal_title：BMC genomics

authors： Fernandez M,Riveros JD,Campos M,Mathee K,Narasimhan G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in patients with cystic fibrosis. The bacterium survives within macrophages by interfering with endocytic trafficking and delaying the maturation of the B. cenocepacia-containing phagosome. We hypothesize that B. cenoce...

journal_title：BMC genomics

authors： Tolman JS,Valvano MA

更新日期：2012-02-09 00:00:00

abstract：:ᅟ: Upon publication of the original article [1], the authors had flagged that there was an error in Fig. 1c, as the key in this figure was displaying incorrectly. The colours had not displayed in the key in the final published article, and instead appear as plain white. ...

journal_title：BMC genomics

authors： Hohmann N,Koch MA

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Electron microscopy analyses of replicating chloroplast molecules earlier predicted bidirectional Cairns replication as the prevalent mechanism, perhaps followed by rounds of a rolling circle mechanism. This standard model is being challenged by the recent proposition of homologous recombination-mediated rep...

journal_title：BMC genomics

authors： Krishnan NM,Rao BJ

更新日期：2009-05-20 00:00:00

abstract：BACKGROUND:Mitochondrial genomes (mtDNA) of multicellular animals (Metazoa) with bilateral symmetry (Bilateria) are compact and usually carry 13 protein-coding genes for subunits of three respiratory complexes and ATP synthase. However, occasionally reported exceptions to this typical mtDNA organization prompted specul...

journal_title：BMC genomics

authors： Szafranski P

更新日期：2017-03-31 00:00:00