Comparison of gene coverage of mouse oligonucleotide microarray platforms.

abstract：BACKGROUND:Due to the high morbidity and mortality of fulminant hepatitis, early diagnosis followed by early effective treatment is the key for prognosis improvement. So far, little is known about the gene expression changes in the early stage of this serious illness. Identification of the genes related to the very ear...

journal_title：BMC genomics

authors： Chen F,Zhu HH,Zhou LF,Li J,Zhao LY,Wu SS,Wang J,Liu W,Chen Z

更新日期：2010-04-15 00:00:00

abstract：BACKGROUND:Fusion genes are known to be drivers of many common cancers, so they are potential markers for diagnosis, prognosis or therapy response. The advent of paired-end RNA sequencing enhances our ability to discover fusion genes. While there are available methods, routine analyses of large number of samples are st...

journal_title：BMC genomics

authors： Vu TN,Deng W,Trac QT,Calza S,Hwang W,Pawitan Y

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Much of the morphological diversity in eukaryotes results from differential regulation of gene expression in which transcription factors (TFs) play a central role. The nematode Caenorhabditis elegans is an established model organism for the study of the roles of TFs in controlling the spatiotemporal pattern ...

journal_title：BMC genomics

authors： Haerty W,Artieri C,Khezri N,Singh RS,Gupta BP

更新日期：2008-08-27 00:00:00

abstract：BACKGROUND:The substantially large bread wheat genome, organized into highly similar three sub-genomes, renders genomic research challenging. The construction of BAC-based physical maps of individual chromosomes reduces the complexity of this allohexaploid genome, enables elucidation of gene space and evolutionary rela...

journal_title：BMC genomics

authors： Akpinar BA,Magni F,Yuce M,Lucas SJ,Šimková H,Šafář J,Vautrin S,Bergès H,Cattonaro F,Doležel J,Budak H

更新日期：2015-06-13 00:00:00

abstract：BACKGROUND:Cytoplasmic male sterility (CMS) is an inability to produce functional pollen that is caused by mutation of the mitochondrial genome. Comparative analyses of mitochondrial genomes of lines with and without CMS in several species have revealed structural differences between genomes, including extensive rearra...

journal_title：BMC genomics

authors： Jo YD,Choi Y,Kim DH,Kim BD,Kang BC

更新日期：2014-07-04 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a large family of endogenous, non-coding RNAs, about 22 nucleotides long, which regulate gene expression through sequence-specific base pairing with target mRNAs. Extensive studies have shown that miRNA expression in the skin changes remarkably during distinct stages of the hair cycle ...

journal_title：BMC genomics

authors： Yuan C,Wang X,Geng R,He X,Qu L,Chen Y

更新日期：2013-07-28 00:00:00

abstract：BACKGROUND:Common carp (Cyprinus carpio) is thought to have undergone one extra round of genome duplication compared to zebrafish. Transcriptome analysis has been used to study the existence and timing of genome duplication in species for which genome sequences are incomplete. Large-scale transcriptome data for the com...

journal_title：BMC genomics

authors： Wang JT,Li JT,Zhang XF,Sun XW

更新日期：2012-03-19 00:00:00

abstract：BACKGROUND:Genome-scale pooled CRISPR screens are powerful tools for identifying genetic dependencies across varied cellular processes. The vast majority of CRISPR screens reported to date have focused exclusively on the perturbation of protein-coding gene function. However, protein-coding genes comprise < 2% of the se...

journal_title：BMC genomics

authors： Borys SM,Younger ST

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However, there is no information about the changes produced by the wounds...

journal_title：BMC genomics

authors： Cordero H,Brinchmann MF,Cuesta A,Esteban MA

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabol...

journal_title：BMC genomics

authors： Fonknechten N,Chaussonnerie S,Tricot S,Lajus A,Andreesen JR,Perchat N,Pelletier E,Gouyvenoux M,Barbe V,Salanoubat M,Le Paslier D,Weissenbach J,Cohen GN,Kreimeyer A

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Previous studies suggest genome structure is largely conserved between Eucalyptus species. However, it is unknown if this conservation extends to more divergent eucalypt taxa. We performed comparative genomics between the eucalypt genera Eucalyptus and Corymbia. Our results will facilitate transfer of genomi...

journal_title：BMC genomics

authors： Butler JB,Vaillancourt RE,Potts BM,Lee DJ,King GJ,Baten A,Shepherd M,Freeman JS

更新日期：2017-05-22 00:00:00

abstract：BACKGROUND:Human T cell leukemia virus type 1 (HTLV-1) Tax is a potent activator of viral and cellular gene expression that interacts with a number of cellular proteins. Many reports show that Tax is capable of regulating cell cycle progression and apoptosis both positively and negatively. However, it still remains to ...

journal_title：BMC genomics

authors： Arainga M,Murakami H,Aida Y

更新日期：2012-06-22 00:00:00

abstract：BACKGROUND:Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend themselves against ROS/RNS, bacteria possess a subsystem of detoxification enzymes, which are classi...

journal_title：BMC genomics

authors： Thybert D,Avner S,Lucchetti-Miganeh C,Chéron A,Barloy-Hubler F

更新日期：2008-12-31 00:00:00

abstract：BACKGROUND:Long terminal repeat retrotransposons are the most abundant transposons in plants. They play important roles in alternative splicing, recombination, gene regulation, and defense mechanisms. Large-scale sequencing projects for plant genomes are currently underway. Software tools are important for annotating l...

journal_title：BMC genomics

authors： Valencia JD,Girgis HZ

更新日期：2019-06-03 00:00:00

abstract：BACKGROUND:Paenibacillus larvae is a Firmicute bacterium that causes American Foulbrood, a lethal disease in honeybees and is a major source of global agricultural losses. Although P. larvae phages were isolated prior to 2013, no full genome sequences of P. larvae bacteriophages were published or analyzed. This report ...

journal_title：BMC genomics

authors： Merrill BD,Grose JH,Breakwell DP,Burnett SH

更新日期：2014-08-30 00:00:00

abstract：BACKGROUND:Olfaction is a versatile sensory mechanism for detecting thousands of volatile odorants. Although molecular basis of odorant signaling is relatively well understood considerable gaps remain in the complete charting of all relevant gene products. To address this challenge, we applied RNAseq to four well-chara...

journal_title：BMC genomics

authors： Olender T,Keydar I,Pinto JM,Tatarskyy P,Alkelai A,Chien MS,Fishilevich S,Restrepo D,Matsunami H,Gilad Y,Lancet D

更新日期：2016-08-11 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：BMC genomics

authors： Assefa AT,Vandesompele J,Thas O

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:The Transcription Factor (TF) p63 is a master regulator of epidermal development and differentiation as evident from the remarkable skin phenotype of p63 mouse knockouts. Furthermore, ectopic expression of p63 alone is sufficient to convert simple epithelium into stratified epithelial tissues in vivo and p63...

journal_title：BMC genomics

authors： Sethi I,Sinha S,Buck MJ

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:Precise identification of three-dimensional genome organization, especially enhancer-promoter interactions (EPIs), is important to deciphering gene regulation, cell differentiation and disease mechanisms. Currently, it is a challenging task to distinguish true interactions from other nearby non-interacting o...

journal_title：BMC genomics

authors： Zeng W,Wu M,Jiang R

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Infectious laryngotracheitis virus (ILTV; gallid herpesvirus 1) infection causes high mortality and huge economic losses in the poultry industry. To protect chickens against ILTV infection, chicken-embryo origin (CEO) and tissue-culture origin (TCO) vaccines have been used. However, the transmission of vacci...

journal_title：BMC genomics

authors： Lee J,Bottje WG,Kong BW

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Missing data is an inevitable phenomenon in gene expression microarray experiments due to instrument failure or human error. It has a negative impact on performance of downstream analysis. Technically, most existing approaches suffer from this prevalent problem. Imputation is one of the frequently used metho...

journal_title：BMC genomics

authors： Li H,Zhao C,Shao F,Li GZ,Wang X

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Oil palm is the second largest source of edible oil which contributes to approximately 20% of the world's production of oils and fats. In order to understand the molecular biology involved in in vitro propagation, flowering, efficient utilization of nitrogen sources and root diseases, we have initiated an ex...

journal_title：BMC genomics

authors： Ho CL,Kwan YY,Choi MC,Tee SS,Ng WH,Lim KA,Lee YP,Ooi SE,Lee WW,Tee JM,Tan SH,Kulaveerasingam H,Alwee SS,Abdullah MO

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs (miRNAs) have become a major therapeutic focus as their pervasive expression and powerful regulatory roles in disease pathogenesis become increasingly a...

journal_title：BMC genomics

authors： Kocerha J,Kouri N,Baker M,Finch N,DeJesus-Hernandez M,Gonzalez J,Chidamparam K,Josephs KA,Boeve BF,Graff-Radford NR,Crook J,Dickson DW,Rademakers R

更新日期：2011-10-27 00:00:00

abstract：BACKGROUND:The green crab Carcinus maenas is known for its high acclimation potential to varying environmental abiotic conditions. A high ability for ion and acid-base regulation is mainly based on an efficient regulation apparatus located in gill epithelia. However, at present it is neither known which ion transport p...

journal_title：BMC genomics

authors： Fehsenfeld S,Kiko R,Appelhans Y,Towle DW,Zimmer M,Melzner F

更新日期：2011-10-06 00:00:00

abstract：BACKGROUND:Banana and plantain (Musa spp.) comprise an important part of diets for millions of people around the globe. Low temperature is one of the key environmental stresses which greatly affects the global banana production. To understand the molecular mechanism of the cold-tolerance in plantain we used RNA-Seq bas...

journal_title：BMC genomics

authors： Yang QS,Gao J,He WD,Dou TX,Ding LJ,Wu JH,Li CY,Peng XX,Zhang S,Yi GJ

更新日期：2015-06-10 00:00:00

abstract：BACKGROUND:Lychas mucronatus is one scorpion species widely distributed in Southeast Asia and southern China. Anything is hardly known about its venom components, despite the fact that it can often cause human accidents. In this work, we performed a venomous gland transcriptome analysis by constructing and screening th...

journal_title：BMC genomics

authors： Ruiming Z,Yibao M,Yawen H,Zhiyong D,Yingliang W,Zhijian C,Wenxin L

更新日期：2010-07-28 00:00:00

abstract：BACKGROUND:Malaria, caused by the parasitic protist Plasmodium falciparum, represents a major public health problem in the developing world. The P. falciparum genome has been sequenced, which provides new opportunities for the identification of novel drug targets. Eukaryotic protein kinases (ePKs) form a large family o...

journal_title：BMC genomics

authors： Ward P,Equinet L,Packer J,Doerig C

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:The establishment of C4 photosynthesis in maize is associated with differential accumulation of gene transcripts and proteins between bundle sheath and mesophyll photosynthetic cell types. We have physically separated photosynthetic cell types in the leaf blade to characterize differences in gene expression ...

journal_title：BMC genomics

authors： Sawers RJ,Liu P,Anufrikova K,Hwang JT,Brutnell TP

更新日期：2007-01-09 00:00:00

abstract：BACKGROUND:Currently, diabetes has become one of the leading causes of death worldwide. Fasting plasma glucose (FPG) levels that are higher than optimal, even if below the diagnostic threshold of diabetes, can also lead to increased morbidity and mortality. Here we intend to study the magnitude of the genetic influence...

journal_title：BMC genomics

authors： Wang W,Zhang C,Liu H,Xu C,Duan H,Tian X,Zhang D

更新日期：2020-07-18 00:00:00

abstract：BACKGROUND:Plant nucleotide-binding site (NBS)-leucine-rich repeat (LRR) proteins encoded by resistance genes play an important role in the responses of plants to various pathogens, including viruses, bacteria, fungi, and nematodes. In this study, a comprehensive analysis of NBS-encoding genes within the whole cucumber...

journal_title：BMC genomics

authors： Wan H,Yuan W,Bo K,Shen J,Pang X,Chen J

更新日期：2013-02-19 00:00:00