Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components.

abstract：BACKGROUND:Malaria caused by Plasmodium vivax is an experimentally neglected severe disease with a substantial burden on human health. Because of technical limitations, little is known about the biology of this important human pathogen. Whole genome analysis methods on patient-derived material are thus likely to have a...

journal_title：BMC genomics

authors： Bright AT,Tewhey R,Abeles S,Chuquiyauri R,Llanos-Cuentas A,Ferreira MU,Schork NJ,Vinetz JM,Winzeler EA

更新日期：2012-06-21 00:00:00

abstract：BACKGROUND:Short non-coding RNAs (ncRNAs) perform their cellular functions in ribonucleoprotein (RNP) complexes, which are also essential for maintaining the stability of the ncRNAs. Depletion of individual protein components of non-coding ribonucleoprotein (ncRNP) particles by RNA interference (RNAi) may therefore aff...

journal_title：BMC genomics

authors： Aftab MN,He H,Skogerbø G,Chen R

更新日期：2008-06-11 00:00:00

abstract：BACKGROUND:Copy number variants (CNVs) have been shown to increase risk for physical anomalies, developmental, psychiatric and medical disorders. Some of them have been associated with changes in weight, height, and other physical traits. As most studies have been performed on children and young people, these effects o...

journal_title：BMC genomics

authors： Owen D,Bracher-Smith M,Kendall KM,Rees E,Einon M,Escott-Price V,Owen MJ,O'Donovan MC,Kirov G

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:Thymoma is a heterogeneous group of tumors in biology and clinical behavior. Even though thymoma is divided into five subgroups following the World Health Organization classification, the nature of the disease is mixed within the subgroups. RESULTS:We investigated the molecular characteristics of genetic ch...

journal_title：BMC genomics

authors： Lee GY,Yang WI,Jeung HC,Kim SC,Seo MY,Park CH,Chung HC,Rha SY

更新日期：2007-09-03 00:00:00

abstract：BACKGROUND:Chloroplasts have their own genomes, independent from nuclear genomes, that play vital roles in growth, which is a major targeted trait for genetic improvement in Populus. Angiosperm chloroplast genomes are maternally inherited, but the chloroplast' variation pattern of poplar at the single-base level during...

journal_title：BMC genomics

authors： Zhu S,Xu M,Wang H,Pan H,Wang G,Huang M

更新日期：2018-05-29 00:00:00

abstract：BACKGROUND:Tomato plant growth is frequently hampered by a high susceptibility to pests and diseases. Traditional chemical control causes a serious impact on both the environment and human health. Therefore, seeking environment-friendly and cost-effective green methods in agricultural production becomes crucial nowaday...

journal_title：BMC genomics

authors： Zhou L,Song C,Li Z,Kuipers OP

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Prediction methods are increasingly used in biosciences to forecast diverse features and characteristics. Binary two-state classifiers are the most common applications. They are usually based on machine learning approaches. For the end user it is often problematic to evaluate the true performance and applica...

journal_title：BMC genomics

authors： Vihinen M

更新日期：2012-06-18 00:00:00

abstract：BACKGROUND:Evolution leaves an imprint in species through genetic change. At the molecular level, evolutionary changes can be explored by studying ratios of nucleotide substitutions. The interplay among molecular evolution, derived phenotypes, and ecological ranges can provide insights into adaptive radiations. Caecili...

journal_title：BMC genomics

authors： Torres-Sánchez M,Gower DJ,Alvarez-Ponce D,Creevey CJ,Wilkinson M,San Mauro D

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Despite the importance of chromosomal translocations in the initiation and/or progression of cancer, a comprehensive catalog of translocation breakpoints in which these are precisely located on the reference sequence of the human genome is not available at present. DESCRIPTION:We have created a database tha...

journal_title：BMC genomics

authors： Novo FJ,de Mendíbil IO,Vizmanos JL

更新日期：2007-01-26 00:00:00

abstract：BACKGROUND:The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT). The method is built on two information-theoretic metrics, the k-way interaction inf...

journal_title：BMC genomics

authors： Chanda P,Sucheston L,Liu S,Zhang A,Ramanathan M

更新日期：2009-11-04 00:00:00

abstract：BACKGROUND:Recent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement ...

journal_title：BMC genomics

authors： Taylor-Brown A,Bachmann NL,Borel N,Polkinghorne A

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in young children. The degree of disease severity is determined by the host response to infection. Lung macrophages play an important early role in the host response to infection and we have used a systems-based appr...

journal_title：BMC genomics

authors： Ravi LI,Li L,Sutejo R,Chen H,Wong PS,Tan BH,Sugrue RJ

更新日期：2013-03-18 00:00:00

abstract：BACKGROUND:Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases. Aneuploidies frequently affect only a subset of cells in a sample; this is known as "mosaic" aneuploidy. A cell that harbours an aneup...

journal_title：BMC genomics

authors： Griffiths JA,Scialdone A,Marioni JC

更新日期：2017-11-25 00:00:00

abstract：BACKGROUND:Non-coding RNAs (ncRNAs), which perform diverse regulatory roles, have been found in organisms from all superkingdoms of life. However, there have been limited numbers of studies on the functions of ncRNAs, especially in nonmodel organisms such as Kluyveromyces marxianus that is widely used in the field of i...

journal_title：BMC genomics

authors： Cho YB,Lee EJ,Cho S,Kim TY,Park JH,Cho BK

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Comparative genomics approaches have facilitated the discovery of many novel non-coding and structured RNAs (ncRNAs). The increasing availability of related genomes now makes it possible to systematically search for compensatory base changes - and thus for conserved secondary structures - even in genomic reg...

journal_title：BMC genomics

authors： Kirsch R,Seemann SE,Ruzzo WL,Cohen SM,Stadler PF,Gorodkin J

更新日期：2018-12-11 00:00:00

abstract：BACKGROUND:LEF1/TCF transcription factors and their activator β-catenin are effectors of the canonical Wnt pathway. Although Wnt/β-catenin signaling has been implicated in neurodegenerative and psychiatric disorders, its possible role in the adult brain remains enigmatic. To address this issue, we sought to identify th...

journal_title：BMC genomics

authors： Wisniewska MB,Nagalski A,Dabrowski M,Misztal K,Kuznicki J

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:Musa species (Zingiberaceae, Zingiberales) including bananas and plantains are collectively the fourth most important crop in developing countries. Knowledge concerning Musa genome structure and the origin of distinct cultivars has greatly increased over the last few years. Until now, however, no large-scale...

journal_title：BMC genomics

authors： Lescot M,Piffanelli P,Ciampi AY,Ruiz M,Blanc G,Leebens-Mack J,da Silva FR,Santos CM,D'Hont A,Garsmeur O,Vilarinhos AD,Kanamori H,Matsumoto T,Ronning CM,Cheung F,Haas BJ,Althoff R,Arbogast T,Hine E,Pappas GJ Jr,Sas

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:Copy neutral loss of heterozygosity (CN-LOH) refers to a special case of LOH occurring without any resulting loss in copy number. These alterations is sometimes seen in tumors as a way to inactivate a tumor suppressor gene and have been found to be important in several types of cancer. RESULTS:We have used ...

journal_title：BMC genomics

authors： Kryh H,Carén H,Erichsen J,Sjöberg RM,Abrahamsson J,Kogner P,Martinsson T

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:The Chinese Taihu is one of the most prolific pig breeds in the world, which farrows at least five more piglets per litter than Western pig breeds partly due to a greater ovulation rate. Variation of ovulation rate maybe associated with the differences in the transcriptome of Chinese Taihu and Large White ov...

journal_title：BMC genomics

authors： Sun X,Mei S,Tao H,Wang G,Su L,Jiang S,Deng C,Xiong Y,Li F

更新日期：2011-02-16 00:00:00

abstract：BACKGROUND:Alternative splicing (AS) regulation is extensive and shapes the functional complexity of higher organisms. However, the contribution of alternative splicing to fungal biology is not well studied. RESULTS:This study provides sequences of the transcriptomes of the plant wilt pathogen Verticillium dahliae, us...

journal_title：BMC genomics

authors： Jin L,Li G,Yu D,Huang W,Cheng C,Liao S,Wu Q,Zhang Y

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Aeromonas salmonicida subsp. salmonicida is a ubiquitous psychrophilic waterborne bacterium and a fish pathogen. The numerous mobile elements, especially insertion sequences (IS), in its genome promote rearrangements that impact its phenotype. One of the main virulence factors of this bacterium, its type thr...

journal_title：BMC genomics

authors： Tanaka KH,Vincent AT,Emond-Rheault JG,Adamczuk M,Frenette M,Charette SJ

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:Litchi (Litchi chinensis Sonn.) is an economically important evergreen fruit tree widely cultivated in subtropical areas. Low temperature is absolutely required for floral induction of litchi, but its molecular mechanism is not fully understood. Leaves of litchi played a key role during floral induction and ...

journal_title：BMC genomics

authors： Zhang H,Shen J,Wei Y,Chen H

更新日期：2017-05-10 00:00:00

abstract：BACKGROUND:Copy number variation (CNV) is a major component of genomic variation, yet methods to accurately type genomic CNV lag behind methods that type single nucleotide variation. High-throughput sequencing can contribute to these methods by using sequence read depth, which takes the number of reads that map to a gi...

journal_title：BMC genomics

authors： Forni D,Martin D,Abujaber R,Sharp AJ,Sironi M,Hollox EJ

更新日期：2015-11-02 00:00:00

abstract：BACKGROUND:In many eukaryotes, microRNAs (miRNAs) bind to complementary sites in the 3'-untranslated regions (3'-UTRs) of target messenger RNAs (mRNAs) and regulate their expression at the stage of translation. Recent studies have revealed that many miRNAs are evolutionarily conserved; however, the evolution of their t...

journal_title：BMC genomics

authors： Takane K,Fujishima K,Watanabe Y,Sato A,Saito N,Tomita M,Kanai A

更新日期：2010-02-09 00:00:00

abstract：BACKGROUND:The Xanthomonas citri pv. citri (X. citri) is a phytopathogenic bacterium that infects different species of citrus plants where it causes canker disease. The adaptation to different habitats is related to the ability of the cells to metabolize and to assimilate diverse compounds, including sulfur, an essenti...

journal_title：BMC genomics

authors： Pereira CT,Moutran A,Fessel M,Balan A

更新日期：2015-07-14 00:00:00

abstract：BACKGROUND:The ribosome is a central player in the translation system, which in mammals consists of four RNA species and 79 ribosomal proteins (RPs). The control mechanisms of gene expression and the functions of RPs are believed to be identical. Most RP genes have common promoters and were therefore assumed to have a ...

journal_title：BMC genomics

authors： Ishii K,Washio T,Uechi T,Yoshihama M,Kenmochi N,Tomita M

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:Streptococcus infantarius subsp. infantarius (Sii) belongs to the Streptococcus bovis/Streptococcus equinus complex associated with several human and animal infections. Sii is a predominant bacterium in spontaneously fermented milk products in Africa. The genome sequence of Sii strain CJ18 was compared with ...

journal_title：BMC genomics

authors： Jans C,Follador R,Hochstrasser M,Lacroix C,Meile L,Stevens MJ

更新日期：2013-03-22 00:00:00

abstract：BACKGROUND:The laying hen model of spontaneous epithelial ovarian cancer (EOC) is unique in that it is the only model that enables observations of early events in disease progression and is therefore also uniquely suited for chemoprevention trials. Previous studies on the effect of dietary flaxseed in laying hens have ...

journal_title：BMC genomics

authors： Hales KH,Speckman SC,Kurrey NK,Hales DB

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:The study and analysis of gene expression measurements is the primary focus of functional genomics. Once expression data is available, biologists are faced with the task of extracting (new) knowledge associated to the underlying biological phenomenon. Most often, in order to perform this task, biologists exe...

journal_title：BMC genomics

authors： Miyazaki FA,Guardia GD,Vêncio RZ,de Farias CR

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder that is clinically defined in terms of motor symptoms. These are preceded by prodromal non-motor manifestations that prove the systemic nature of the disease. Identifying genes and pathways altered in living patients provide new inf...

journal_title：BMC genomics

authors： Calligaris R,Banica M,Roncaglia P,Robotti E,Finaurini S,Vlachouli C,Antonutti L,Iorio F,Carissimo A,Cattaruzza T,Ceiner A,Lazarevic D,Cucca A,Pangher N,Marengo E,di Bernardo D,Pizzolato G,Gustincich S

更新日期：2015-10-28 00:00:00