Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer.

abstract：BACKGROUND:The capacity of European pear fruit (Pyrus communis L.) to ripen after harvest develops during the final stages of growth on the tree. The objective of this study was to characterize changes in 'Bartlett' pear fruit physico-chemical properties and transcription profiles during fruit maturation leading to att...

journal_title：BMC genomics

authors： Nham NT,de Freitas ST,Macnish AJ,Carr KM,Kietikul T,Guilatco AJ,Jiang CZ,Zakharov F,Mitcham EJ

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Much of the morphological diversity in eukaryotes results from differential regulation of gene expression in which transcription factors (TFs) play a central role. The nematode Caenorhabditis elegans is an established model organism for the study of the roles of TFs in controlling the spatiotemporal pattern ...

journal_title：BMC genomics

authors： Haerty W,Artieri C,Khezri N,Singh RS,Gupta BP

更新日期：2008-08-27 00:00:00

abstract：BACKGROUND:Rainbow trout is a significant fish farming species under temperate climates. Female reproduction traits play an important role in the economy of breeding companies with the sale of fertilized eggs. The objectives of this study are threefold: to estimate the genetic parameters of female reproduction traits, ...

journal_title：BMC genomics

authors： D'Ambrosio J,Morvezen R,Brard-Fudulea S,Bestin A,Acin Perez A,Guéméné D,Poncet C,Haffray P,Dupont-Nivet M,Phocas F

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:The recently developed RNA interference (RNAi) technology has created an unprecedented opportunity which allows the function of individual genes in whole organisms or cell lines to be interrogated at genome-wide scale. However, multiple issues, such as off-target effects or low efficacies in knocking down ce...

journal_title：BMC genomics

authors： Wang L,Tu Z,Sun F

更新日期：2009-05-12 00:00:00

abstract：BACKGROUND:The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway has been well-characterized as a crucial signal transduction cascade that regulates vital biological responses including development, immunity and oncogenesis. Additionally to its canonical pathway that uses the phosphorylat...

journal_title：BMC genomics

authors： Tsurumi A,Zhao C,Li WX

更新日期：2017-09-11 00:00:00

abstract：BACKGROUND:In biomedical research, gene expression profiling studies have been extensively conducted. The analysis of gene expression data has led to a deeper understanding of human genetics as well as practically useful models. Clustering analysis has been a critical component of gene expression data analysis and can ...

journal_title：BMC genomics

authors： Teran Hidalgo SJ,Wu M,Ma S

更新日期：2017-08-16 00:00:00

abstract：BACKGROUND:Transmembrane β-barrel proteins are a special class of transmembrane proteins which play several key roles in human body and diseases. Due to experimental difficulties, the number of transmembrane β-barrel proteins with known structures is very small. Over the years, a number of learning-based methods have b...

journal_title：BMC genomics

authors： Tran Vdu T,Chassignet P,Sheikh S,Steyaert JM

更新日期：2012-04-12 00:00:00

abstract：BACKGROUND:Bifidobacterial genome analysis has provided insights as to how these gut commensals adapt to and persist in the human GIT, while also revealing genetic diversity among members of a given bifidobacterial (sub)species. Bifidobacteria are notoriously recalcitrant to genetic modification, which prevents explora...

journal_title：BMC genomics

authors： O'Callaghan A,Bottacini F,O'Connell Motherway M,van Sinderen D

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Genome-wide expression profiles are altered during biological aging and can describe molecular regulation of tissue degeneration. Age-regulated mRNA expression trends from cross-sectional studies could describe how aging progresses. We developed a novel statistical methodology to identify age-regulated expre...

journal_title：BMC genomics

authors： Gheorghe M,Snoeck M,Emmerich M,Bäck T,Goeman JJ,Raz V

更新日期：2014-02-14 00:00:00

abstract：BACKGROUND:Rare genetic variation in the human population is a major source of pathophysiological variability and has been implicated in a host of complex phenotypes and diseases. Finding disease-related genes harboring disparate functional rare variants requires sequencing of many individuals across many genomic regio...

journal_title：BMC genomics

authors： Ramos E,Levinson BT,Chasnoff S,Hughes A,Young AL,Thornton K,Li A,Vallania FL,Province M,Druley TE

更新日期：2012-12-06 00:00:00

abstract：BACKGROUND:Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend themselves against ROS/RNS, bacteria possess a subsystem of detoxification enzymes, which are classi...

journal_title：BMC genomics

authors： Thybert D,Avner S,Lucchetti-Miganeh C,Chéron A,Barloy-Hubler F

更新日期：2008-12-31 00:00:00

abstract：BACKGROUND:A-to-I RNA-editing mediated by ADAR (adenosine deaminase acting on RNA) enzymes that converts adenosine to inosine in RNA sequence can generate mutations and alter gene regulation in metazoans. Previous studies have shown that A-to-I RNA-editing plays vital roles in mouse embryogenesis. However, the RNA-edit...

journal_title：BMC genomics

authors： Qiu S,Li W,Xiong H,Liu D,Bai Y,Wu K,Zhang X,Yang H,Ma K,Hou Y,Li B

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:The Gram-negative bacterium Chlamydia pneumoniae (Cpn) is the leading intracellular human pathogen responsible for respiratory infections such as pneumonia and bronchitis. Basic and applied research in pathogen biology, especially the elaboration of new mechanism-based anti-pathogen strategies, target discov...

journal_title：BMC genomics

authors： Maier CJ,Maier RH,Virok DP,Maass M,Hintner H,Bauer JW,Onder K

更新日期：2012-11-16 00:00:00

abstract：BACKGROUND:We present here the assembly of the bovine genome. The assembly method combines the BAC plus WGS local assembly used for the rat and sea urchin with the whole genome shotgun (WGS) only assembly used for many other animal genomes including the rhesus macaque. RESULTS:The assembly process consisted of multipl...

journal_title：BMC genomics

authors： Liu Y,Qin X,Song XZ,Jiang H,Shen Y,Durbin KJ,Lien S,Kent MP,Sodeland M,Ren Y,Zhang L,Sodergren E,Havlak P,Worley KC,Weinstock GM,Gibbs RA

更新日期：2009-04-24 00:00:00

abstract：BACKGROUND:The insect order Neuroptera encompasses more than 5,700 described species. To date, only three neuropteran mitochondrial genomes have been fully and one partly sequenced. Current knowledge on neuropteran mitochondrial genomes is limited, and new data are strongly required. In the present work, the mitochondr...

journal_title：BMC genomics

authors： Negrisolo E,Babbucci M,Patarnello T

更新日期：2011-05-10 00:00:00

abstract：BACKGROUND:Identifying the genotypes underlying human disease phenotypes is a fundamental step in human genetics and medicine. High-throughput genomic technologies provide thousands of genetic variants per individual. The causal genes of a specific phenotype are usually expected to be functionally close to each other. ...

journal_title：BMC genomics

authors： Itan Y,Mazel M,Mazel B,Abhyankar A,Nitschke P,Quintana-Murci L,Boisson-Dupuis S,Boisson B,Abel L,Zhang SY,Casanova JL

更新日期：2014-04-03 00:00:00

abstract：BACKGROUND:Genome research in farm animals will expand our basic knowledge of the genetic control of complex traits, and the results will be applied in the livestock industry to improve meat quality and productivity, as well as to reduce the incidence of disease. A combination of quantitative trait locus mapping and mi...

journal_title：BMC genomics

authors： Kim TH,Kim NS,Lim D,Lee KT,Oh JH,Park HS,Jang GW,Kim HY,Jeon M,Choi BH,Lee HY,Chung HY,Kim H

更新日期：2006-02-27 00:00:00

abstract：BACKGROUND:Use of genomic tools to characterize wildlife populations has increased in recent years. In the past, genetic characterization has been accomplished with more traditional genetic tools (e.g., microsatellites). The explosion of genomic methods and the subsequent creation of large SNP datasets has led to the p...

journal_title：BMC genomics

authors： Zimmerman SJ,Aldridge CL,Oyler-McCance SJ

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The relationships between parasitoids and their insect hosts have attracted attention at two levels. First, the basic biology of host-parasitoid interactions is of fundamental interest. Second, parasitoids are widely used as biological control agents in sustainable agricultural programs. Females of the grega...

journal_title：BMC genomics

authors： Fang Q,Wang L,Zhu J,Li Y,Song Q,Stanley DW,Akhtar ZR,Ye G

更新日期：2010-09-02 00:00:00

abstract：BACKGROUND:It has been shown that nearly a quarter of the initial predicted gene models in the Plasmodium falciparum genome contain errors. Although there have been efforts to obtain complete cDNA sequences to correct the errors, the coverage of cDNA sequences on the predicted genes is still incomplete, and many gene m...

journal_title：BMC genomics

authors： López-Barragán MJ,Lemieux J,Quiñones M,Williamson KC,Molina-Cruz A,Cui K,Barillas-Mury C,Zhao K,Su XZ

更新日期：2011-11-30 00:00:00

abstract：BACKGROUND:Oligonucleotide microarray-based comparative genomic hybridization (CGH) offers an attractive possible route for the rapid and cost-effective genome-wide discovery of deletion mutations. CGH typically involves comparison of the hybridization intensities of genomic DNA samples with microarray chip representat...

journal_title：BMC genomics

authors： Belfield EJ,Brown C,Gan X,Jiang C,Baban D,Mithani A,Mott R,Ragoussis J,Harberd NP

更新日期：2014-03-22 00:00:00

abstract：BACKGROUND:Precision medicine is a medical approach that takes into account individual genetic variability and often requires Next Generation Sequencing data in order to predict new treatments. Here we present GMIEC, Genomic Modules Identification et Characterization for genomics medicine, an application that is able t...

journal_title：BMC genomics

authors： Malagoli Tagliazucchi G,Taccioli C

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gain-of-function screens are less common, although some reports have utilized arrayed viral expression ...

journal_title：BMC genomics

authors： Feddersen CR,Wadsworth LS,Zhu EY,Vaughn HR,Voigt AP,Riordan JD,Dupuy AJ

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Gaucher disease is caused by defective glucocerebrosidase activity and the consequent accumulation of glucosylceramide. The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure. RESULTS:To elucidate this pathogenic pathway, de...

journal_title：BMC genomics

authors： Xu YH,Jia L,Quinn B,Zamzow M,Stringer K,Aronow B,Sun Y,Zhang W,Setchell KD,Grabowski GA

更新日期：2011-01-11 00:00:00

abstract：BACKGROUND:The spiral cleavage mode of early development is utilized in over one-third of all animal phyla and generates embryonic cells of different size, position, and fate through a conserved set of stereotypic and invariant asymmetric cell divisions. Despite the widespread use of spiral cleavage, regulatory and mol...

journal_title：BMC genomics

authors： Chou HC,Pruitt MM,Bastin BR,Schneider SQ

更新日期：2016-08-05 00:00:00

abstract：BACKGROUND:Tandem mass spectrometry (MS/MS) has become a standard method for identification of proteins extracted from biological samples but the huge number and the noise contamination of MS/MS spectra obstruct swift and reliable computer-aided interpretation. Typically, a minor fraction of the spectra per sample (mos...

journal_title：BMC genomics

authors： Mujezinovic N,Schneider G,Wildpaner M,Mechtler K,Eisenhaber F

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:On a single strand of genomic DNA the number of As is usually about equal to the number of Ts (and similarly for Gs and Cs), but deviations have been noted for transcribed regions and origins of replication. RESULTS:The mouse genome is shown to have a segmented structure defined by strand bias. Transcriptio...

journal_title：BMC genomics

authors： Evans KJ

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:Wild sugarcane Saccharum spontaneum plants vary in ploidy, which complicates the utilization of its germplasm in sugarcane breeding. Investigations on cold tolerance in relation to different ploidies in S. spontaneum may promote the exploitation of its germplasm and accelerate the improvement of sugarcane va...

journal_title：BMC genomics

authors： Yang H,Wang T,Yu X,Yang Y,Wang C,Yang Q,Wang X

更新日期：2020-07-22 00:00:00

abstract：:We describe an emerging initiative - the 'Functional Annotation of All Salmonid Genomes' (FAASG), which will leverage the extensive trait diversity that has evolved since a whole genome duplication event in the salmonid ancestor, to develop an integrative understanding of the functional genomic basis of phenotypic var...

journal_title：BMC genomics

authors： Macqueen DJ,Primmer CR,Houston RD,Nowak BF,Bernatchez L,Bergseth S,Davidson WS,Gallardo-Escárate C,Goldammer T,Guiguen Y,Iturra P,Kijas JW,Koop BF,Lien S,Maass A,Martin SAM,McGinnity P,Montecino M,Naish KA,Nichols K

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNF) is able to induce a variety of biological responses in the nervous system including inflammation and neuroprotection. Human astrocytoma cells U373 have been widely used as a model for inflammatory cytokine actions in the nervous system. Here we used cDNA microarrays to analy...

journal_title：BMC genomics

authors： Schwamborn J,Lindecke A,Elvers M,Horejschi V,Kerick M,Rafigh M,Pfeiffer J,Prüllage M,Kaltschmidt B,Kaltschmidt C

更新日期：2003-11-25 00:00:00