Phytochemical and comparative transcriptome analyses reveal different regulatory mechanisms in the terpenoid biosynthesis pathways between Matricaria recutita L. and Chamaemelum nobile L.


BACKGROUND:Matricaria recutita (German chamomile) and Chamaemelum nobile (Roman chamomile) belong to the botanical family Asteraceae. These two herbs are not only morphologically distinguishable, but their secondary metabolites - especially the essential oils present in flowers are also different, especially the terpenoids. The aim of this project was to preliminarily identify regulatory mechanisms in the terpenoid biosynthetic pathways that differ between German and Roman chamomile by performing comparative transcriptomic and metabolomic analyses. RESULTS:We determined the content of essential oils in disk florets and ray florets in these two chamomile species, and found that the terpenoid content in flowers of German chamomile is greater than that of Roman chamomile. In addition, a comparative RNA-seq analysis of German and Roman chamomile showed that 54% of genes shared > 75% sequence identity between the two species. In particular, more highly expressed DEGs (differentially expressed genes) and TF (transcription factor) genes, different regulation of CYPs (cytochrome P450 enzymes), and rapid evolution of downstream genes in the terpenoid biosynthetic pathway of German chamomile could be the main reasons to explain the differences in the types and levels of terpenoid compounds in these two species. In addition, a phylogenetic tree constructed from single copy genes showed that German chamomile and Roman chamomile are closely related to Chrysanthemum nankingense. CONCLUSION:This work provides the first insights into terpenoid biosynthesis in two species of chamomile. The candidate unigenes related to terpenoid biosynthesis will be important in molecular breeding approaches to modulate the essential oil composition of Matricaria recutita and Chamaemelum nobile.


BMC Genomics


BMC genomics


Tai Y,Hou X,Liu C,Sun J,Guo C,Su L,Jiang W,Ling C,Wang C,Wang H,Pan G,Si X,Yuan Y




Has Abstract


2020-02-18 00:00:00












  • Genetic diversity of male and female Chinese bayberry (Myrica rubra) populations and identification of sex-associated markers.

    abstract:BACKGROUND:Chinese bayberry (Myrica rubra Sieb. & Zucc.) is an important subtropical evergreen fruit tree in southern China. Generally dioecious, the female plants are cultivated for fruit and have been studied extensively, but male plants have received very little attention. Knowledge of males may have a major impact ...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Jia HM,Jiao Y,Wang GY,Li YH,Jia HJ,Wu HX,Chai CY,Dong X,Guo Y,Zhang L,Gao QK,Chen W,Song LJ,van de Weg E,Gao ZS

    更新日期:2015-05-19 00:00:00

  • Genome-wide analysis of the effect of histone modifications on the coexpression of neighboring genes in Saccharomyces cerevisiae.

    abstract:BACKGROUND:Neighboring gene pairs in the genome of Saccharomyces cerevisiae have a tendency to be expressed at the same time. The distribution of histone modifications along chromatin fibers is suggested to be an important mechanism responsible for such coexpression. However, the extent of the contribution of histone m...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Deng Y,Dai X,Xiang Q,Dai Z,He C,Wang J,Feng J

    更新日期:2010-10-09 00:00:00

  • A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae.

    abstract:BACKGROUND:The understanding of the biological function, regulation, and cellular interactions of the yeast genome and proteome, along with the high conservation in gene function found between yeast genes and their human homologues, has allowed for Saccharomyces cerevisiae to be used as a model organism to deduce biolo...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Arita A,Zhou X,Ellen TP,Liu X,Bai J,Rooney JP,Kurtz A,Klein CB,Dai W,Begley TJ,Costa M

    更新日期:2009-11-15 00:00:00

  • Comparative genome analysis of Streptococcus infantarius subsp. infantarius CJ18, an African fermented camel milk isolate with adaptations to dairy environment.

    abstract:BACKGROUND:Streptococcus infantarius subsp. infantarius (Sii) belongs to the Streptococcus bovis/Streptococcus equinus complex associated with several human and animal infections. Sii is a predominant bacterium in spontaneously fermented milk products in Africa. The genome sequence of Sii strain CJ18 was compared with ...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Jans C,Follador R,Hochstrasser M,Lacroix C,Meile L,Stevens MJ

    更新日期:2013-03-22 00:00:00

  • Identification of common carp (Cyprinus carpio) microRNAs and microRNA-related SNPs.

    abstract:BACKGROUND:MicroRNAs (miRNAs) exist pervasively across viruses, plants and animals and play important roles in the post-transcriptional regulation of genes. In the common carp, miRNA targets have not been investigated. In model species, single-nucleotide polymorphisms (SNPs) have been reported to impair or enhance miRN...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Zhu YP,Xue W,Wang JT,Wan YM,Wang SL,Xu P,Zhang Y,Li JT,Sun XW

    更新日期:2012-08-21 00:00:00

  • Structure, phylogeny, allelic haplotypes and expression of sucrose transporter gene families in Saccharum.

    abstract:BACKGROUND:Sugarcane is an economically important crop contributing to about 80% of the world sugar production. Increasing efforts in molecular biological studies have been performed for improving the sugar yield and other relevant important agronomic traits. However, due to sugarcane's complicated genomes, it is still...

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    pub_type: 杂志文章


    authors: Zhang Q,Hu W,Zhu F,Wang L,Yu Q,Ming R,Zhang J

    更新日期:2016-02-01 00:00:00

  • Proteome dynamics and early salt stress response of the photosynthetic organism Chlamydomonas reinhardtii.

    abstract:BACKGROUND:The cellular proteome and metabolome are underlying dynamic regulation allowing rapid adaptation to changes in the environment. System-wide analysis of these dynamics will provide novel insights into mechanisms of stress adaptation for higher photosynthetic organisms. We applied pulsed-SILAC labeling to a ph...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Mastrobuoni G,Irgang S,Pietzke M,Assmus HE,Wenzel M,Schulze WX,Kempa S

    更新日期:2012-05-31 00:00:00

  • Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds.

    abstract:BACKGROUND:Tea is one of the most popular non-alcoholic beverages worldwide. However, the tea plant, Camellia sinensis, is difficult to culture in vitro, to transform, and has a large genome, rendering little genomic information available. Recent advances in large-scale RNA sequencing (RNA-seq) provide a fast, cost-eff...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Shi CY,Yang H,Wei CL,Yu O,Zhang ZZ,Jiang CJ,Sun J,Li YY,Chen Q,Xia T,Wan XC

    更新日期:2011-02-28 00:00:00

  • Transcriptional response to sulfide in the Echiuran Worm Urechis unicinctus by digital gene expression analysis.

    abstract:BACKGROUND:Urechis unicinctus, an echiuran worm inhabiting the U-shaped burrows in the coastal mud flats, is an important commercial and ecological invertebrate in Northeast Asian countries, which has potential applications in the study of animal evolution, coastal sediment improvement and marine drug development. Furt...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Liu X,Zhang L,Zhang Z,Ma X,Liu J

    更新日期:2015-10-21 00:00:00

  • Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia.

    abstract:BACKGROUND:The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very late relapse. TEL/AM...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Gandemer V,Rio AG,de Tayrac M,Sibut V,Mottier S,Ly Sunnaram B,Henry C,Monnier A,Berthou C,Le Gall E,Le Treut A,Schmitt C,Le Gall JY,Mosser J,Galibert MD

    更新日期:2007-10-23 00:00:00

  • A hybrid imputation approach for microarray missing value estimation.

    abstract:BACKGROUND:Missing data is an inevitable phenomenon in gene expression microarray experiments due to instrument failure or human error. It has a negative impact on performance of downstream analysis. Technically, most existing approaches suffer from this prevalent problem. Imputation is one of the frequently used metho...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Li H,Zhao C,Shao F,Li GZ,Wang X

    更新日期:2015-01-01 00:00:00

  • Unravelling the complex trait of harvest index in rapeseed (Brassica napus L.) with association mapping.

    abstract:BACKGROUND:Harvest index (HI), the ratio of grain yield to total biomass, is considered as a measure of biological success in partitioning assimilated photosynthate to the harvestable product. While crop production can be dramatically improved by increasing HI, the underlying molecular genetic mechanism of HI in rapese...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Luo X,Ma C,Yue Y,Hu K,Li Y,Duan Z,Wu M,Tu J,Shen J,Yi B,Fu T

    更新日期:2015-05-12 00:00:00

  • Comparative analysis of surface-exposed virulence factors of Acinetobacter baumannii.

    abstract:BACKGROUND:Acinetobacter baumannii is a significant hospital pathogen, particularly due to the dissemination of highly multidrug resistant isolates. Genome data have revealed that A. baumannii is highly genetically diverse, which correlates with major variations seen at the phenotypic level. Thus far, comparative genom...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Eijkelkamp BA,Stroeher UH,Hassan KA,Paulsen IT,Brown MH

    更新日期:2014-11-25 00:00:00

  • Genome-wide analyses of Epstein-Barr virus reveal conserved RNA structures and a novel stable intronic sequence RNA.

    abstract:BACKGROUND:Epstein-Barr virus (EBV) is a human herpesvirus implicated in cancer and autoimmune disorders. Little is known concerning the roles of RNA structure in this important human pathogen. This study provides the first comprehensive genome-wide survey of RNA and RNA structure in EBV. RESULTS:Novel EBV RNAs and RN...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Moss WN,Steitz JA

    更新日期:2013-08-09 00:00:00

  • Whole genome scanning and association mapping identified a significant association between growth and a SNP in the IFABP-a gene of the Asian seabass.

    abstract:BACKGROUND:Aquaculture is the quickest growing sector in agriculture. However, QTL for important traits have been only identified in a few aquaculture species. We conducted QTL mapping for growth traits in an Asian seabass F(2) family with 359 individuals using 123 microsatellites and 22 SNPs, and performed association...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Xia JH,Lin G,He X,Liu P,Liu F,Sun F,Tu R,Yue GH

    更新日期:2013-05-01 00:00:00

  • Whole exome sequencing (WES) on formalin-fixed, paraffin-embedded (FFPE) tumor tissue in gastrointestinal stromal tumors (GIST).

    abstract:BACKGROUND:Next generation sequencing (NGS) technology has been rapidly introduced into basic and translational research in oncology, but the reduced availability of fresh frozen (FF) tumor tissues and the poor quality of DNA extracted from formalin-fixed, paraffin-embedded (FFPE) has significantly impaired this proces...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Astolfi A,Urbini M,Indio V,Nannini M,Genovese CG,Santini D,Saponara M,Mandrioli A,Ercolani G,Brandi G,Biasco G,Pantaleo MA

    更新日期:2015-11-03 00:00:00

  • Genome-wide survey of two-component signal transduction systems in the plant growth-promoting bacterium Azospirillum.

    abstract:BACKGROUND:Two-component systems (TCS) play critical roles in sensing and responding to environmental cues. Azospirillum is a plant growth-promoting rhizobacterium living in the rhizosphere of many important crops. Despite numerous studies about its plant beneficial properties, little is known about how the bacterium s...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Borland S,Oudart A,Prigent-Combaret C,Brochier-Armanet C,Wisniewski-Dyé F

    更新日期:2015-10-22 00:00:00

  • How Athila retrotransposons survive in the Arabidopsis genome.

    abstract:BACKGROUND:Transposable elements are selfish genetic sequences which only occasionally provide useful functions to their host species. In addition, models of mobile element evolution assume a second type of selfishness: elements of different families do not cooperate, but they independently fight for their survival in ...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Marco A,Marín I

    更新日期:2008-05-14 00:00:00

  • GBS-based single dosage markers for linkage and QTL mapping allow gene mining for yield-related traits in sugarcane.

    abstract:BACKGROUND:Sugarcane (Saccharum spp.) is predominantly an autopolyploid plant with a variable ploidy level, frequent aneuploidy and a large genome that hampers investigation of its organization. Genetic architecture studies are important for identifying genomic regions associated with traits of interest. However, due t...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Balsalobre TW,da Silva Pereira G,Margarido GR,Gazaffi R,Barreto FZ,Anoni CO,Cardoso-Silva CB,Costa EA,Mancini MC,Hoffmann HP,de Souza AP,Garcia AA,Carneiro MS

    更新日期:2017-01-11 00:00:00

  • Proteome-wide analysis of Anopheles culicifacies mosquito midgut: new insights into the mechanism of refractoriness.

    abstract:BACKGROUND:Midgut invasion, a major bottleneck for malaria parasites transmission is considered as a potential target for vector-parasite interaction studies. New intervention strategies are required to explore the midgut proteins and their potential role in refractoriness for malaria control in Anopheles mosquitoes. T...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Vijay S,Rawal R,Kadian K,Singh J,Adak T,Sharma A

    更新日期:2018-05-08 00:00:00

  • COMUS: Clinician-Oriented locus-specific MUtation detection and deposition System.

    abstract:BACKGROUND:A disease-causing mutation refers to a heritable genetic change that is associated with a specific phenotype (disease). The detection of a mutation from a patient's sample is critical for the diagnosis, treatment, and prognosis of the disease. There are numerous databases and applications with which to archi...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Jho S,Kim BC,Ghang H,Kim JH,Park D,Kim HM,Jung SY,Yoo KY,Kim HJ,Lee S,Bhak J

    更新日期:2009-12-03 00:00:00

  • Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies.

    abstract:BACKGROUND:Genetic influences underpinning complex traits are thought to involve multiple quantitative trait loci (QTLs) of small effect size. Detection of such QTL associations requires systematic screening of large numbers of DNA markers within large sample populations. Using pooled DNA on SNP microarrays to screen f...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Docherty SJ,Butcher LM,Schalkwyk LC,Plomin R

    更新日期:2007-07-04 00:00:00

  • Linkage disequilibrium and genome-wide association analysis for anthocyanin pigmentation and fruit color in eggplant.

    abstract:BACKGROUND:The genome-wide association (GWA) approach represents an alternative to biparental linkage mapping for determining the genetic basis of trait variation. Both approaches rely on recombination to re-arrange the genome, and seek to establish correlations between phenotype and genotype. The major advantages of G...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Cericola F,Portis E,Lanteri S,Toppino L,Barchi L,Acciarri N,Pulcini L,Sala T,Rotino GL

    更新日期:2014-10-14 00:00:00

  • Subtelomere organization in the genome of the microsporidian Encephalitozoon cuniculi: patterns of repeated sequences and physicochemical signatures.

    abstract:BACKGROUND:The microsporidian Encephalitozoon cuniculi is an obligate intracellular eukaryotic pathogen with a small nuclear genome (2.9 Mbp) consisting of 11 chromosomes. Although each chromosome end is known to contain a single rDNA unit, the incomplete assembly of subtelomeric regions following sequencing of the gen...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Dia N,Lavie L,Faye N,Méténier G,Yeramian E,Duroure C,Toguebaye BS,Frutos R,Niang MN,Vivarès CP,Ben Mamoun C,Cornillot E

    更新日期:2016-01-07 00:00:00

  • Genome-wide analysis of purple acid phosphatase structure and expression in ten vegetable species.

    abstract:BACKGROUND:Acquisition of external phosphorus (P) and optimisation of internal P are essential for plant growth and development, and insufficient availability of P in soils is a major challenge in agriculture. Members of the purple acid phosphatase (PAP) family of enzymes are candidates for increasing P use efficiency....

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Xie L,Shang Q

    更新日期:2018-08-31 00:00:00

  • A hybrid expectation maximisation and MCMC sampling algorithm to implement Bayesian mixture model based genomic prediction and QTL mapping.

    abstract:BACKGROUND:Bayesian mixture models in which the effects of SNP are assumed to come from normal distributions with different variances are attractive for simultaneous genomic prediction and QTL mapping. These models are usually implemented with Monte Carlo Markov Chain (MCMC) sampling, which requires long compute times ...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Wang T,Chen YP,Bowman PJ,Goddard ME,Hayes BJ

    更新日期:2016-09-21 00:00:00

  • Time course of the response to ACTH in pig: biological and transcriptomic study.

    abstract:BACKGROUND:HPA axis plays a major role in physiological homeostasis. It is also involved in stress and adaptive response to the environment. In farm animals in general and specifically in pigs, breeding strategies have highly favored production traits such as lean growth rate, feed efficiency and prolificacy at the cos...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Sautron V,Terenina E,Gress L,Lippi Y,Billon Y,Larzul C,Liaubet L,Villa-Vialaneix N,Mormède P

    更新日期:2015-11-17 00:00:00

  • Connecting rules from paired miRNA and mRNA expression data sets of HCV patients to detect both inverse and positive regulatory relationships.

    abstract:BACKGROUND:Intensive research based on the inverse expression relationship has been undertaken to discover the miRNA-mRNA regulatory modules involved in the infection of Hepatitis C virus (HCV), the leading cause of chronic liver diseases. However, biological studies in other fields have found that inverse expression r...

    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Song R,Liu Q,Liu T,Li J

    更新日期:2015-01-01 00:00:00

  • Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.

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    journal_title:BMC genomics

    pub_type: 杂志文章,meta分析


    authors: Mullin BH,Walsh JP,Zheng HF,Brown SJ,Surdulescu GL,Curtis C,Breen G,Dudbridge F,Richards JB,Spector TD,Wilson SG

    更新日期:2016-02-25 00:00:00

  • OxyGene: an innovative platform for investigating oxidative-response genes in whole prokaryotic genomes.

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    journal_title:BMC genomics

    pub_type: 杂志文章


    authors: Thybert D,Avner S,Lucchetti-Miganeh C,Chéron A,Barloy-Hubler F

    更新日期:2008-12-31 00:00:00