Abstract:
:Resveratrol is a natural compound present in red grapes and red wine, and is often consumed in the human diet. The chemopreventive and chemotherapeutic potential of resveratrol in hepatocellular carcinoma (HCC), one of the most common types of liver cancer, has received much attention in recent years. However, the side-effects of resveratrol stimulation are of concern due to the high doses administered to humans. This study investigated the effects of resveratrol on the mRNA expression of pten and bcl-xl in HepG2 cells using semi-quantitative and quantitative PCR. This study demonstrated that 200 µmol/l resveratrol stimulation for 12 h resulted in the inhibition of HepG2 proliferation, reduced pten and increased bcl-xl mRNA expression. The data suggest that (a) the anticancer mechanism of resveratrol does not involve the induction of pten and inhibition of bcl-xl expression and (b) resveratrol induces a cellular self-protection response, which underlies the cellular chemoresistance against resveratrol in HepG2 cells.
journal_name
Mol Med Repjournal_title
Molecular medicine reportsauthors
Zheng M,Chen R,Zhong H,Lin Q,Wang X,Zhao Z,Xie Ldoi
10.3892/mmr.2012.1077subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1367-70issue
6eissn
1791-2997issn
1791-3004journal_volume
6pub_type
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