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Potent HGF/c-Met axis inhibitors from Eucalyptus globulus: the coupling of phloroglucinol and sesquiterpenoid is essential for the activity.

Abstract：

:Eucalyptin A (1), together with two known compounds 2 and 3 exhibiting potent inhibition on HGF/c-Met axis, was discovered from the fruits of Eucalyptus globulus. 1 possessed an unprecedented carbon framework of phloroglucinol-coupled sesquiterpenoid, and its structure was elucidated by spectroscopic method and ECD calculation. A brief structure-activity relationship discussion indicated that the coupling of a phloroglucinol and a sesquiterpenoid is essential for the activity.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Yang SP,Zhang XW,Ai J,Gan LS,Xu JB,Wang Y,Su ZS,Wang L,Ding J,Geng MY,Yue JM

doi

10.1021/jm3007454

subject

Has Abstract

pub_date

2012-09-27 00:00:00

pages

8183-7

issue

18

eissn

0022-2623

issn

1520-4804

journal_volume

55

pub_type

杂志文章

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