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The effects of N-terminal part modification of arginine vasopressin analogues with 2-aminoindane-2-carboxylic acid: a highly potent V2 agonist.

Abstract：

:In this study we present the synthesis and some pharmacological properties of nine new analogues of arginine vasopressin modified in the N-terminal part of the molecule with 2-aminoindane-2-carboxylic acid (Aic). The peptides were tested for their in vitro uterotonic and in vivo pressor and antidiuretic activities. One of the new peptides, [Mpa1,Aic2,Val4,D-Arg8]VP, exhibited an antidiuretic activity similar to that of [Mpa1,D-Arg8]VP, thus being one of the most potent antidiuretic vasopressin analogues reported to date.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Kowalczyk W,Sobolewski D,Prahl A,Derdowska I,Borovicková L,Slaninová J,Lammek B

doi

10.1021/jm070174s

subject

Has Abstract

pub_date

2007-06-14 00:00:00

pages

2926-9

issue

12

eissn

0022-2623

issn

1520-4804

journal_volume

50

pub_type

杂志文章

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