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Structure-activity relationship of the ficin hydrolysis of phenyl hippurates. Comparison with papain, actinidin, and bromelain.

Abstract：

:A study of the hydrolysis of 30 substituted-phenyl hippurates by the enzyme ficin has been made. From the results the following quantitative structure--activity relationship (QSAR) has been derived: log 1/Km = 0.79 pi'3 + 0.58 sigma + 0.28 MR4,5 + 3.70. In this expression Km is the Michaelis constant, pi'3 refers to the more hydrophobic of the two meta substituents, and MR4,5 is the molar refractivity of substituents in the 4- and 5-positions of the phenyl ring. This QSAR is compared with those from papain, actinidin, bromelain B, and bromelain D.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Carotti A,Casini G,Hansch C

doi

10.1021/jm00377a009

subject

Has Abstract

pub_date

1984-11-01 00:00:00

pages

1427-31

issue

11

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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