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2 beta-substituted analogues of cocaine. Synthesis and inhibition of binding to the cocaine receptor.

Abstract：

:The potencies of a series of 2 beta-substituted cocaine analogues to displace [3H]-3 beta-(p-fluorophenyl)tropane-2 beta-carboxylic acid methyl ester binding in rat striatal membranes demonstrate the requirement for a 2 beta-substituent with two hydrogen-bond acceptors. The insensitivity of the ester moiety to steric and electronic factors suggests its modification to provide site-specific irreversible ligands.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Lewin AH,Gao YG,Abraham P,Boja JW,Kuhar MJ,Carroll FI

doi

10.1021/jm00079a017

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

135-40

issue

1

eissn

0022-2623

issn

1520-4804

journal_volume

35

pub_type

杂志文章

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