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Phototoxicity of chlorpromazine.

Abstract：

:The constitution of chlorpromazine has been studied in the context of its phototoxicity. Electron transfer from the side chain to the aromatic nucleus of the drug contributes to its instability to light. Even without the side chain, however, chlorophenothiazines appear to be very photolabile, so that it is unlikely that nonphototoxic analogues of chlorpromazine can be prepared merely by altering the constitution of the side chain.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Bunce NJ,Kumar Y,Ravanal L

doi

10.1021/jm00188a016

subject

Has Abstract

pub_date

1979-02-01 00:00:00

pages

202-4

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

22

pub_type

杂志文章

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