Comparative study on the pregnancy outcomes of in vitro fertilization-embryo transfer between long-acting gonadotropin-releasing hormone agonist combined with transvaginal ultrasound-guided cyst aspiration and long-acting gonadotropin-releasing hormone ag

abstract：BACKGROUND:Despite efforts by the U.S. Department of Defense to train behavioral health (BH) providers in evidence-based psychotherapies (EBPs) for posttraumatic stress disorder (PTSD), numerous barriers limit EBP implementation. A context-tailored implementation approach called TACTICS (Targeted Assessment and Context...

journal_title：Contemporary clinical trials

authors： Rosen CS,Davis CA,Riggs D,Cook J,Peterson AL,Young-McCaughan S,Comtois KA,Haddock CK,Borah EV,Dondanville KA,Finley EP,Jahnke SA,Poston WSC,Wiltsey-Stirman S,Neitzer A,Broussard CR,Brzuchalski MA,Clayton MSP,Conforte

更新日期：2020-06-01 00:00:00

abstract：:Pediatric primary care is an important setting in which to address obesity prevention, yet relatively few interventions have been evaluated and even fewer have been shown to be effective. The development and evaluation of cost-effective approaches to obesity prevention that leverage opportunities of direct access to f...

journal_title：Contemporary clinical trials

authors： Sherwood NE,Levy RL,Langer SL,Senso MM,Crain AL,Hayes MG,Anderson JD,Seburg EM,Jeffery RW

更新日期：2013-09-01 00:00:00

abstract：:Researchers have long sought to find combinations of cancer drugs that might achieve synergy. However, while observed in some preclinical tumor models, synergistic effects are rarely seen in clinical trials. In fact, growing evidence in clinical trial data shows that the treatment effect of most approved combination t...

journal_title：Contemporary clinical trials

authors： Chen C,Liu F,Ren Y,Suttner L,Sun Z,Shentu Y,Schmidt EV

更新日期：2020-11-01 00:00:00

abstract：:This pilot study examined knowledge, understanding and perceived acceptability of key methodological concepts in clinical trials among injecting drug users (IDUs) in Sydney, Australia. Participants were clinical trial-experienced (n = 17) and trial-naïve (n = 99) IDUs recruited from community needle and syringe progra...

journal_title：Contemporary clinical trials

authors： Doab A,Topp L,Day CA,Dore GJ,Maher L

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:To assess parental decision making and experiences in an autologous umbilical cord blood infusion study in young children with type 1 diabetes (T1D). METHODS:Surveys were completed with 22 parents of children with T1D who received infusion and 22 parents who declined infusion. RESULTS:Parents who stored umb...

journal_title：Contemporary clinical trials

authors： Driscoll KA,Johnson SB,Schatz DA,Haller MJ

更新日期：2011-07-01 00:00:00

abstract：:The use of blinding strengthens the credibility of randomized controlled trials (RCTs) by minimizing bias. However, there is confusion surrounding the definition of blinding as well as the terms single, double, and triple blind. It has been suggested that these terms should be discontinued due to their broad misinterp...

journal_title：Contemporary clinical trials

authors： Miller LE,Stewart ME

更新日期：2011-03-01 00:00:00

abstract：:Illustrated is the use of a patient enrichment adaptive design in a randomized phase II trial which allows the evaluation of treatment benefits by the biomarker expression level and makes interim adjustment according to the pre-specified rules. The design was applied to an actual phase II metastatic hepatocellular car...

journal_title：Contemporary clinical trials

authors： Song JX

更新日期：2014-01-01 00:00:00

abstract：:Identifying effective strategies for treating obesity is a clinical challenge and a public health priority. The present study is an innovative test of the relative effectiveness of lottery-based financial incentives and environmental strategies on weight loss and maintenance. The Healthy Weigh study is evaluating the ...

journal_title：Contemporary clinical trials

authors： Glanz K,Shaw PA,Hoffer K,Chung A,Zhu J,Wu R,Huang QE,Choi JR,Volpp KG

更新日期：2019-01-01 00:00:00

abstract：:Phase IIA clinical trials are commonly conducted as pilot studies to evaluate efficacy and safety in selected populations of patients with the disease or condition to be treated or prevented. The efficacy objective is to find preliminarily evidence of the effectiveness or ineffectiveness of study treatments. Go/no-go ...

journal_title：Contemporary clinical trials

authors： Zhong B

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:This article describes the protocol for a Hybrid Type I cost-effectiveness and implementation study of interpersonal psychotherapy (IPT) for men and women prisoners with major depressive disorder (MDD). The goal is to promote uptake of evidence-based treatments in criminal justice settings by conducting a rando...

journal_title：Contemporary clinical trials

authors： Johnson JE,Miller TR,Stout RL,Zlotnick C,Cerbo LA,Andrade JT,Wiltsey-Stirman S

更新日期：2016-03-01 00:00:00

abstract：:This randomized, controlled trial tested the effectiveness of a nurse-run, telephone-based intervention to improve lipid control in patients with diabetes. Our patient population is predominantly low-income and Latino. Using our diabetes registry, we randomly assigned 381 patients to continue with their usual care and...

journal_title：Contemporary clinical trials

authors： Fischer H,Mackenzie T,McCullen K,Everhart R,Estacio RO

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:The comprehension of informed consent is an integral part of clinical trials. Though India is rapidly becoming a hub of clinical trials very few studies have dealt with the issue of comprehension of informed consent by the patients participating in these trials. METHODS:Patients who were invited to particip...

journal_title：Contemporary clinical trials

authors： Bhansali S,Shafiq N,Malhotra S,Pandhi P,Singh I,Venkateshan SP,Siddhu S,Sharma YP,Talwar KK

更新日期：2009-09-01 00:00:00

abstract：:Suicide remains the 10th leading cause of death among adults in the United States (U.S.). Annually, approximately 30 per 100,000 U.S. military Veterans commit suicide, compared to 14 per 100,000 U.S. civilians. Symptoms associated with suicidality can be treatment resistant and proven-effective pharmaceuticals may hav...

journal_title：Contemporary clinical trials

authors： Marriott BP,Hibbeln JR,Killeen TK,Magruder KM,Holes-Lewis K,Tolliver BK,Turner TH,BRAVO Group.

更新日期：2016-03-01 00:00:00

abstract：:The HIV pandemic is a pressing threat to global public health; HIV vaccine development is critical. Clinical evaluation of HIV vaccine candidates differs from the standard therapeutics trial framework primarily due to the fact that healthy individuals are studied. We present an early stage evaluation program developed...

journal_title：Contemporary clinical trials

authors： Moodie Z,Rossini AJ,Hudgens MG,Gilbert PB,Self SG,Russell ND

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Bipolar Disorder (BD) is a common and severe form of mental illness. Pharmacotherapy is the main treatment offered, but has limited effectiveness, and there is increasing evidence that people with BD respond well to psychological interventions. Inequalities in access to face-to-face psychological interventio...

journal_title：Contemporary clinical trials

authors： Todd NJ,Solis-Trapala I,Jones SH,Lobban FA

更新日期：2012-07-01 00:00:00

abstract：:The usual development cycles are too slow for the development of vaccines, diagnostics and treatments in pandemics such as the ongoing SARS-CoV-2 pandemic. Given the pressure in such a situation, there is a risk that findings of early clinical trials are overinterpreted despite their limitations in terms of size and d...

journal_title：Contemporary clinical trials

authors： Friedrich S,Friede T

更新日期：2020-12-01 00:00:00

abstract：:An instrumental variable (IV) estimator has been widely used to estimate causal effects among compliers in randomized trials with noncompliance. The estimator of complier average treatment effect can be expressed as a ratio of two unbiased estimators but the ratio estimator is not unbiased. The bias of IV estimator ca...

journal_title：Contemporary clinical trials

authors： Chan KC

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) increases the risk of thromboembolic stroke. An oral anticoagulant should be administrated to prevent stroke in patients with moderate stroke risk (ie, CHA2DS2-VASc score>2). If the stroke risk is low (i.e. the score=1), however, antiplatelet agent such as aspirin is widely used. Asp...

journal_title：Contemporary clinical trials

authors： Park SM,Jeong H,Jung MH,Hong KS,Hong MK,Bang CS,Kim CY

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Focal ablation therapy is playing an increasing role in oncology and may reduce the toxicity of current surgical treatments while achieving adequate oncological benefit. Irreversible electroporation (IRE) has been proposed to be tissue-selective with potential advantages compared with current thermal-ablat...

journal_title：Contemporary clinical trials

authors： Wendler JJ,Porsch M,Nitschke S,Köllermann J,Siedentopf S,Pech M,Fischbach F,Ricke J,Schostak M,Liehr UB

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIMS:Cocaine use disorder (CUD) persists as a major public health problem in the United States. Response to evidence-based behavioral treatment has been shown to be predicted by dopaminergic dysfunction. Amphetamine formulations modulate dopaminergic systems and are one of the few agents with positive clinic...

journal_title：Contemporary clinical trials

authors： Blevins D,Carpenter KM,Martinez D,Mariani JJ,Levin FR

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability. The current anti-inflammatory treatments for MS have little or no efficacy in PMS in the absence of obvious active inflammation. Optimal ...

journal_title：Contemporary clinical trials

authors： Fox RJ,Coffey CS,Cudkowicz ME,Gleason T,Goodman A,Klawiter EC,Matsuda K,McGovern M,Conwit R,Naismith R,Ashokkumar A,Bermel R,Ecklund D,Koepp M,Long J,Natarajan S,Ramachandran S,Skaramagas T,Thornell B,Yankey J,Agi

更新日期：2016-09-01 00:00:00

abstract：:Smokers are at high risk for oral disease. As a result, they represent an important target group for population-level, public oral health promotion efforts. While dental health professionals often address smoking with their patients, no systematic efforts have been made to offer smokers an intervention to improve thei...

journal_title：Contemporary clinical trials

authors： McClure JB,Blasi PR,Cook A,Bush T,Fishman P,Nelson J,Anderson ML,Catz SL

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:This paper reports the protocol of a randomised, double-blind, placebo-controlled study to test the efficacy, safety, and tolerability of lubiprostone (LUB) vs. placebo on suppressing gut permeability in non-alcoholic fatty liver disease (NAFLD) patients with constipation. NAFLD, including non-alcoholic stea...

journal_title：Contemporary clinical trials

authors： Kessoku T,Imajo K,Kobayashi T,Honda Y,Kato T,Ogawa Y,Tomeno W,Kato S,Higurashi T,Yoneda M,Kirikoshi H,Kubota K,Taguri M,Yamanaka T,Usuda H,Wada K,Saito S,Nakajima A

更新日期：2018-06-01 00:00:00

abstract：:Parents of young children with type 1 diabetes (T1D) experience unique, developmental challenges in managing their child's T1D, resulting in psychosocial distress. Only a small portion of young children reach glucose goals and adherence to diabetes devices that help improve T1D management have historically been low in...

journal_title：Contemporary clinical trials

authors： Berget C,Driscoll KA,Lagges A,Lange S,DiMeglio LA,Hannon TS,Woerner SE,Iturralde E,Barley RC,Hanes S,Hood KK,Buckingham BB,Toddler Diabetes Technology Study Group.

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To describe the strategies-based on the social triad concept of a partnership of researchers, school personnel and community-employed to recruit low-income, minority parent/caregivers of kindergarten children into a school-based tooth decay prevention trial in the United States. METHODS:The study site was an u...

journal_title：Contemporary clinical trials

authors： Nelson S,Milgrom P

更新日期：2012-01-01 00:00:00

abstract：:Recruiting sufficient patients within an acceptable time horizon is an issue for most clinical trials and is especially challenging in the field of rare diseases. It is therefore an attractive option to include historical data from previous (pilot) trials in the current study thus reducing the recruitment burden. In c...

journal_title：Contemporary clinical trials

authors： Hees K,Kieser M

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Comparative effectiveness research (CER) evidence on childhood obesity provides the basis for effective screening and management strategies in pediatric primary care. The uses of health information technology including decision support tools in the electronic health records (EHRs), as well as remote and mobi...

journal_title：Contemporary clinical trials

authors： Taveras EM,Marshall R,Horan CM,Gillman MW,Hacker K,Kleinman KP,Koziol R,Price S,Simon SR

更新日期：2013-01-01 00:00:00

abstract：:Cancer related cognitive impairments (CRCI) are frequently reported by patients prior to, during and after medical treatment. Although this cognitive decline severely affects patients' quality of life, little is known about effective treatments. Exercise programs represent a promising supportive strategy in this field...

journal_title：Contemporary clinical trials

authors： Zimmer P,Oberste M,Bloch W,Schenk A,Joisten N,Hartig P,Wolf F,Baumann FT,Garthe A,Hallek M,Elter T

更新日期：2016-07-01 00:00:00

abstract：:A response-adaptive randomization (RAR) design refers to the method in which the probability of treatment assignment changes according to how well the treatments are performing in the trial. Holding the promise of treating more patients with the better treatments, RARs have been successfully implemented in clinical tr...

journal_title：Contemporary clinical trials

authors： Du Y,Wang X,Jack Lee J

更新日期：2015-01-01 00:00:00

abstract：:The combined use of cigarettes and alcohol is associated with an increased risk of morbidity and mortality. Yet, efficacious interventions that address both behaviors concurrently are lacking. Smoking cessation and alcohol modification not only garner health benefits, but there is also value in addressing alcohol use ...

journal_title：Contemporary clinical trials

authors： Hemenway M,Witkiewitz K,Unrod M,Brandon KO,Brandon TH,Wetter DW,Sutton SK,Vinci C

更新日期：2020-11-14 00:00:00