Changes in serum fast and slow skeletal troponin I concentration following maximal eccentric contractions.

Abstract:

OBJECTIVES:We tested the hypothesis that fast skeletal muscle troponin I (fsTnI) concentration in serum would increase more than those of slow skeletal muscle troponin I (ssTnI) after eccentric exercise of the elbow flexors using a sensitive blood marker to track fibre specific muscle damage. DESIGN:Observational comparison of response in a single experimental group. METHODS:Eight young men (26.4±6.2 years) performed 210 (35 sets of 6) eccentric contractions of the elbow flexors on an isokinetic dynamometer with one arm. Changes in serum fsTnI and ssTnI concentrations, serum creatine kinase (CK) activity, and maximal voluntary isometric contraction torque (MVIC) before and 1, 2, 3, 4 and 14 days following exercise were analysed by a Student-Newman-Keuls multiple comparison test. The relationship between serum CK activity and fsTnI or ssTnI concentrations was determined using a Pearson's product moment correlation. RESULTS:Significant (P<0.05) decreases in MVIC and increases in serum CK activity and fsTnI were evident after exercise, but ssTnI did not change. The time course of changes in fsTnI was similar to that of CK, peaking at 4 days post-exercise, and the two were highly correlated (r=0.8). CONCLUSIONS:Increases in serum fsTnI concentrations reflect muscle damage, and it seems likely that only fast twitch fibres were damaged by eccentric contractions.

journal_name

J Sci Med Sport

authors

Chapman DW,Simpson JA,Iscoe S,Robins T,Nosaka K

doi

10.1016/j.jsams.2012.05.006

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

82-5

issue

1

eissn

1440-2440

issn

1878-1861

pii

S1440-2440(12)00104-1

journal_volume

16

pub_type

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