Evaluation of regional and whole gut motility using the wireless motility capsule: relevance in clinical practice.

abstract：Background:Recent evidence has shown that the complete blood count (CBC) is abnormal in patients with Crohn's disease (CD). We aimed to investigate an effective CBC parameter and explore its impact on disease activity in a large CD cohort. Methods:We performed a retrospective analysis of patients with established CD w...

journal_title：Therapeutic advances in gastroenterology

authors： Chen R,Li L,Chao K,Hong M,Cao Q,Ye L,Zhou G,Fang X,Guo H,Cao X,Ye X,Zeng Z,Chen M,Zhang S

更新日期：2020-12-21 00:00:00

abstract：:Crohn's disease (CD) is a chronic relapsing and remitting disorder of the gastrointestinal tract with no known cure. The inflammation that drives the disease can lead to debilitating symptoms and a number of complications that may lead to surgery. The introduction of biologic therapy a decade ago has offered a new opt...

journal_title：Therapeutic advances in gastroenterology

authors： Panaccione R,Ghosh S

更新日期：2010-05-01 00:00:00

abstract：Aims:Gastric cancer (GC) is the third leading cause of cancer death worldwide, but the burden of disease is not distributed evenly. GC screening routinely occurs in some high-incidence regions/countries and is generally cost-effective, which is attributed largely to the associated GC mortality reduction. In regions of ...

journal_title：Therapeutic advances in gastroenterology

authors： Canakis A,Pani E,Saumoy M,Shah SC

更新日期：2020-07-16 00:00:00

abstract：:Severe acute pancreatitis (SAP) is a critical abdominal disease associated with high death rates. A systemic inflammatory response promotes disease progression, resulting in multiple organ dysfunction. The functions of neutrophils in the pathology of SAP have been presumed traditionally to be activation of chemokine a...

journal_title：Therapeutic advances in gastroenterology

authors： Hu J,Kang H,Chen H,Yao J,Yi X,Tang W,Wan M

更新日期：2020-11-24 00:00:00

abstract：:Monoclonal antibodies to tumor necrosis factor (TNF) have become a mainstay of the therapeutic armamentarium in inflammatory bowel disease (IBD) over the last 15 years. Although highly effective, primary and secondary nonresponse are common and associated with poor clinical outcomes and significant costs. Multiple cli...

journal_title：Therapeutic advances in gastroenterology

authors： Kopylov U,Seidman E

更新日期：2016-07-01 00:00:00

abstract：:Functional gastrointestinal disorders, such as irritable bowel syndrome and functional dyspepsia, are complex conditions with multiple factors contributing to their pathophysiology. As a consequence they are difficult to treat and have posed significant challenges to the pharmaceutical industry when trying to develop ...

journal_title：Therapeutic advances in gastroenterology

authors： Sanger GJ,Chang L,Bountra C,Houghton LA

更新日期：2010-09-01 00:00:00

abstract：Background:In patients with a large, unresectable hepatocellular carcinoma (HCC), the primary recommendation is for transarterial chemoembolization (TACE) but used alone TACE is not typically curative. Combinations of TACE followed in a delayed fashion by single-applicator thermal ablation have also been suboptimal. As...

journal_title：Therapeutic advances in gastroenterology

authors： Zhang TQ,Huang ZM,Shen JX,Chen GQ,Shen LJ,Ai F,Gu YK,Yao W,Zhang YY,Guo RP,Chen MS,Huang JH

更新日期：2019-08-21 00:00:00

abstract：:Erratum to 'Possible interactions between dietary fibres and 5-aminosalicyclic acid' by C Henriksen, S Hansen, I Nordgaard-Lassen, J Rikardt Anderson and P Madsen. Therapeutic Advances in Gastroenterology (2010) 3(1) 5-9 [DOI: 10.1177/ 1756283X09347810][This corrects the article on p. 5 in vol. 3.]. ...

journal_title：Therapeutic advances in gastroenterology

authors：

更新日期：2012-09-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is becoming the most common cause of chronic liver disease in the developing world, found in 17-30% of the population in Western countries and 2-4% worldwide. Defined as the accumulation of fatty acid content greater than 5% of liver weight, NAFLD is a spectrum of disease rangi...

journal_title：Therapeutic advances in gastroenterology

authors： Kneeman JM,Misdraji J,Corey KE

更新日期：2012-05-01 00:00:00

abstract：Background:Variability in glucagon-like peptide (GLP)-1 and GLP-2 plasma concentrations has been suggested in Celiac disease (CD), with inconclusive results. We assessed the association between serum levels of GLP-1 and GLP-2 and their duodenal receptor expression in children with and without CD. Methods:This was a tw...

journal_title：Therapeutic advances in gastroenterology

authors： Rachmiel M,Ben-Yehudah G,Shirin H,Broide E

更新日期：2019-04-17 00:00:00

abstract：:Faecal incontinence, defined as the involuntary loss of solid or liquid stool, is a common problem affecting 0.8-8.3% of the adult population. Individuals suffering from faecal incontinence often live a restricted life with reduced quality of life. The present paper is a clinically oriented review of the pathophysiolo...

journal_title：Therapeutic advances in gastroenterology

authors： Duelund-Jakobsen J,Worsoe J,Lundby L,Christensen P,Krogh K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via protease-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosph...

journal_title：Therapeutic advances in gastroenterology

authors： Ammendola M,Sacco R,Vescio G,Zuccalà V,Luposella M,Patruno R,Zizzo N,Gadaleta C,Marech I,Ruggieri R,Kocak IF,Ozgurtas T,Gadaleta CD,Sammarco G,Ranieri G

更新日期：2017-04-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) are gram-negative bacteria that selectively colonizes the gastric mucosa. The prevalence of H. pylori infection varies from 20 to 50% in industrialized countries to over 80% in developing countries. The infection may persist lifelong without specific treatment. Prolonged infection and i...

journal_title：Therapeutic advances in gastroenterology

authors： Lee YC,Liou JM,Wu MS,Wu CY,Lin JT

更新日期：2008-09-01 00:00:00

abstract：:Remarkable advancements in techniques of genomic profiling and bioinformatics have led to the accumulation of vast amounts of knowledge on the genomic profiles of biliary tract cancer (BTC). Recent largescale molecular profiling studies have not only highlighted genomic differences characterizing tumors of the intrahe...

journal_title：Therapeutic advances in gastroenterology

authors： Lee H,Ross JS

更新日期：2017-06-01 00:00:00

abstract：:The human gastrointestinal tract comprises a series of complex and dynamic organs ranging from the stomach to the distal colon, which harbor immense microbial assemblages that are known to be vital for human health. Until recently, most of the details concerning our gut microbiota remained obscure. Over the past sever...

journal_title：Therapeutic advances in gastroenterology

authors： Kovatcheva-Datchary P,Zoetendal EG,Venema K,de Vos WM,Smidt H

更新日期：2009-07-01 00:00:00

abstract：:In recent years, mucosal healing has emerged as a key therapeutic goal in the clinical management of patients with Crohn's disease, as it has been associated with improved long-term clinical outcomes. With the vast improvements in endoscopic imaging techniques and the increase in available treatment options, which rep...

journal_title：Therapeutic advances in gastroenterology

authors： Klenske E,Bojarski C,Waldner M,Rath T,Neurath MF,Atreya R

更新日期：2019-06-14 00:00:00

abstract：BACKGROUND:Diarrhea-predominant irritable bowel syndrome (IBS-D) impairs patient quality of life (QOL). Rifaximin is an oral, nonsystemic antibiotic indicated for IBS-D. The objective of this secondary analysis was to evaluate rifaximin retreatment on IBS-related QOL in patients with IBS-D. METHODS:Patients received o...

journal_title：Therapeutic advances in gastroenterology

authors： Cash BD,Pimentel M,Rao SSC,Weinstock L,Chang L,Heimanson Z,Lembo A

更新日期：2017-09-01 00:00:00

abstract：:Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological cond...

journal_title：Therapeutic advances in gastroenterology

authors： Bien J,Palagani V,Bozko P

更新日期：2013-01-01 00:00:00

abstract：:Sex-based differences in inflammatory bowel disease (IBD) pathogenesis, disease course, and response to therapy have been increasingly recognized, however, not fully understood. Experimental and translational models have been leveraged to investigate hypothesized mechanisms for these observed differences, including th...

journal_title：Therapeutic advances in gastroenterology

authors： Rustgi SD,Kayal M,Shah SC

更新日期：2020-04-28 00:00:00

abstract：:Rates of transmission of hepatitis B virus (HBV) infection from organ donors with HBV markers to recipients along with reactivation of HBV during immunosuppression following transplantation have fallen significantly with the advent of hepatitis B immune globulin (HBIg) and effective antiviral therapy. Although the ava...

journal_title：Therapeutic advances in gastroenterology

authors： John S,Andersson KL,Kotton CN,Hertl M,Markmann JF,Cosimi AB,Chung RT

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Patients with Barrett's esophagus (BE) are commonly treated with proton-pump inhibitors (PPIs) to minimize the exposure of esophageal mucosa to stomach acid. However, the use of these medications can lead to significant hypergastrinemia in a subset of patients, which is concerning due to the known tumorigeni...

journal_title：Therapeutic advances in gastroenterology

authors： Green DA,Mlynarczyk CM,Vaccaro BJ,Capiak KM,Quante M,Lightdale CJ,Abrams JA

更新日期：2011-03-01 00:00:00

abstract：:Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients' prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated b...

journal_title：Therapeutic advances in gastroenterology

authors： Vilaseca M,Guixé-Muntet S,Fernández-Iglesias A,Gracia-Sancho J

更新日期：2018-11-25 00:00:00

abstract：:Capsule endoscopy for the colon was introduced to allow an alternative screening method to the invasive classic colonoscopy. The results of initial studies have shown inferior detection rates of colonic polyps by the colon capsule. In this paper we aim to review and summarize the recent advances in wireless capsule en...

journal_title：Therapeutic advances in gastroenterology

authors： Adler SN,Metzger YC

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Some chronic hepatitis C virus (HCV), genotype 1 infected patients treated with direct antiviral agents (DAAs) remain viremic at end of treatment (EOT+), yet go on to achieve sustained virological response 12 weeks after completion of therapy (SVR12). The incidence of EOT+/SVR in patients with genotype 1 and...

journal_title：Therapeutic advances in gastroenterology

authors： Malespin M,Benyashvili T,Uprichard SL,Perelson AS,Dahari H,Cotler SJ

更新日期：2017-01-01 00:00:00

abstract：Background:Postoperative pancreatic collection (POPC) is a frequent complication after pancreatectomy. Although percutaneous drainage (PD) has been the treatment of choice for POPC with encapsulation, endoscopic ultrasound-guided transmural drainage (EUS-TD) was recently reported effective for this condition. The main ...

journal_title：Therapeutic advances in gastroenterology

authors： Tamura T,Kitano M,Kawai M,Tanioka K,Itonaga M,Kawaji Y,Nuta J,Hatamaru K,Yamashita Y,Kitahata Y,Miyazawa M,Hirono S,Okada KI,Yamaue H

更新日期：2019-10-24 00:00:00

abstract：Background:Vedolizumab (VDZ) is a gut-specific α4-β7 integrin antagonist that has demonstrated efficacy in Crohn's disease (CD) and ulcerative colitis (UC). The safety of VDZ in the perioperative period remains unclear. The aim of this study was to evaluate postoperative complications and perioperative safety in VDZ-tr...

journal_title：Therapeutic advances in gastroenterology

authors： Kotze PG,Ma C,Mckenna N,Almutairdi A,Kaplan GG,Raffals LE,Loftus EV Jr,Panaccione R,Lightner AL

更新日期：2018-06-21 00:00:00

abstract：Background:The environment surrounding Helicobacter pylori eradication treatment is dramatically changing. Recently, vonoprazan, a first-in-class potassium-competitive acid blocker (P-CAB), was introduced onto the market in 2015. The aging of Japan's demographic structure is becoming pronounced. In this study, we exami...

journal_title：Therapeutic advances in gastroenterology

authors： Mori H,Suzuki H,Omata F,Masaoka T,Asaoka D,Kawakami K,Mizuno S,Kurihara N,Nagahara A,Sakaki N,Ito M,Kawamura Y,Suzuki M,Shimada Y,Sasaki H,Matsuhisa T,Torii A,Nishizawa T,Mine T,Ohkusa T,Kawai T,Tokunaga K,Tak

更新日期：2019-07-04 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases and hepatocellular carcinoma (HCC) worldwide. In the past few years, anti-HCV therapies have undergone a revolution with the approval of multiple direct-acting antivirals (DAAs), which enable interferon-free treatments with consider...

journal_title：Therapeutic advances in gastroenterology

authors： Crouchet E,Wrensch F,Schuster C,Zeisel MB,Baumert TF

更新日期：2018-03-21 00:00:00

abstract：Background:The incidence of Clostridioides difficile infection (CDI) is increasing in the general population. Data on the epidemiology of CDI in peripartum women - a highly vulnerable patient population - is scarce. The objective of this study was to report the incidence of CDI in peripartum women. Methods:A single-ce...

journal_title：Therapeutic advances in gastroenterology

authors： Saha S,Pardi R,Theiler RN,Pardi DS,Khanna S

更新日期：2020-07-27 00:00:00

abstract：Background:Recently the American Society for Gastrointestinal Endoscopy addressed the 'resect and discard' strategy, determining that accurate in vivo differentiation of colorectal polyps (CP) is necessary. Previous studies have suggested a promising application of artificial intelligence (AI), using deep learning in o...

journal_title：Therapeutic advances in gastroenterology

authors： Ozawa T,Ishihara S,Fujishiro M,Kumagai Y,Shichijo S,Tada T

更新日期：2020-03-20 00:00:00