Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance.


BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular, MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via protease-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase (MAPK) phosphorylation. Nevertheless, no data are available concerning the relationship among tryptase MC density (TMCD), endothelial cells (ECs) positive to PAR-2 microvascular density (PAR-2-MVD) and classical MVD (C-MVD) in gastric cancer (GC) angiogenesis. METHODS:In this study, we analyzed the correlation of TMCD, PAR-2-MVD, C-MVD with each other and with the main clinicopathological features in GC patients who underwent surgery. A series of 77 GC patients with stage T2-3N2-3M0 (classified by the American Joint Committee on Cancer for Gastric Cancer, 7th edition) were selected and then underwent surgery. RESULTS:Tumour tissue samples were evaluated by mean of immunohistochemistry and image analysis methods in terms of numbers of TMCD, PAR-2-MVD and C-MVD. A significant correlation between the TMCD, PAR-2-MVD and C-MVD groups with each other was found by Pearson t-test analysis (r ranged from 0.64 to 0.76; p value ranged from 0.02 to 0.03). There was no other significant correlation between the above parameters and clinicopathological features. CONCLUSIONS:Our in vivo preliminary data suggest that TMCD and PAR-2-MVD may play a role in GC angiogenesis and they could be further evaluated as a target of antiangiogenic therapy.


Ammendola M,Sacco R,Vescio G,Zuccalà V,Luposella M,Patruno R,Zizzo N,Gadaleta C,Marech I,Ruggieri R,Kocak IF,Ozgurtas T,Gadaleta CD,Sammarco G,Ranieri G




Has Abstract


2017-04-01 00:00:00














  • Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders.

    abstract::Several clinical trials and experimental studies strongly suggest a place for Saccharomyces boulardii as a biotherapeutic agent for the prevention and treatment of several gastrointestinal diseases. S. boulardii mediates responses resembling the protective effects of the normal healthy gut flora. The multiple mechanis...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Kelesidis T,Pothoulakis C

    更新日期:2012-03-01 00:00:00

  • Optimal use of biologics in the management of Crohn's disease.

    abstract::Crohn's disease (CD) is a chronic relapsing and remitting disorder of the gastrointestinal tract with no known cure. The inflammation that drives the disease can lead to debilitating symptoms and a number of complications that may lead to surgery. The introduction of biologic therapy a decade ago has offered a new opt...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Panaccione R,Ghosh S

    更新日期:2010-05-01 00:00:00

  • The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease?

    abstract::Gut microbiota is a compilation of microorganisms dwelling in the entire mammalian gastrointestinal tract. They display a symbiotic relationship with the host contributing to its intestinal health and disease. Even a slight fluctuation in this equipoise may be deleterious to the host, leading to many pathological cond...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Bien J,Palagani V,Bozko P

    更新日期:2013-01-01 00:00:00

  • PillCam COLON capsule endoscopy: recent advances and new insights.

    abstract::Capsule endoscopy for the colon was introduced to allow an alternative screening method to the invasive classic colonoscopy. The results of initial studies have shown inferior detection rates of colonic polyps by the colon capsule. In this paper we aim to review and summarize the recent advances in wireless capsule en...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Adler SN,Metzger YC

    更新日期:2011-07-01 00:00:00

  • Screening colonoscopy bowel preparation: experience in an urban minority population.

    abstract:METHODS:Suboptimal bowel preparation, present in over 20% of colonoscopies, can severely compromise the effectiveness of the colonoscopy procedure. We surveyed 93 primarily urban minority men and women who underwent asymptomatic 'screening' colonoscopy regarding their precolonoscopy bowel-preparation experience. RESUL...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Basch CH,Basch CE,Wolf RL,Zybert P,Lebwohl B,Shmukler C,Neugut AI,Shea S

    更新日期:2013-11-01 00:00:00

  • Cost savings following faecal microbiota transplantation for recurrent Clostridium difficile infection.

    abstract:Background:Recurrent Clostridium difficile infection (rCDI) is becoming increasingly common. Faecal microbiota transplantation (FMT) is effective for rCDI, but the costs of an FMT and hospital cost savings related to FMT are unknown. The aim of this study was to calculate the cost of an FMT and the total hospital costs...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Dehlholm-Lambertsen E,Hall BK,Jørgensen SMD,Jørgensen CW,Jensen ME,Larsen S,Jensen JS,Ehlers L,Dahlerup JF,Hvas CL

    更新日期:2019-04-10 00:00:00

  • Decision model analyses of upper endoscopy for gastric cancer screening and preneoplasia surveillance: a systematic review.

    abstract:Aims:Gastric cancer (GC) is the third leading cause of cancer death worldwide, but the burden of disease is not distributed evenly. GC screening routinely occurs in some high-incidence regions/countries and is generally cost-effective, which is attributed largely to the associated GC mortality reduction. In regions of ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Canakis A,Pani E,Saumoy M,Shah SC

    更新日期:2020-07-16 00:00:00

  • Clostridium difficile infection: management strategies for a difficult disease.

    abstract::Clostridium difficile was first described as a cause of diarrhea in 1978 and in the last three decades has reached an epidemic state with increasing incidence and severity in both healthcare and community settings. There also has been a rise in severe outcomes from C. difficile infection (CDI). There have been tremend...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Khanna S,Pardi DS

    更新日期:2014-03-01 00:00:00

  • The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study.

    abstract:Background:Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Tyrovolas S,Panagiotakos DB,Georgousopoulou EN,Chrysohoou C,Skoumas J,Pan W,Tousoulis D,Pitsavos C

    更新日期:2019-06-23 00:00:00

  • Effectiveness of endoscopic ultrasound-guided drainage for noncapsulated postoperative pancreatic collection.

    abstract:Background:Postoperative pancreatic collection (POPC) is a frequent complication after pancreatectomy. Although percutaneous drainage (PD) has been the treatment of choice for POPC with encapsulation, endoscopic ultrasound-guided transmural drainage (EUS-TD) was recently reported effective for this condition. The main ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Tamura T,Kitano M,Kawai M,Tanioka K,Itonaga M,Kawaji Y,Nuta J,Hatamaru K,Yamashita Y,Kitahata Y,Miyazawa M,Hirono S,Okada KI,Yamaue H

    更新日期:2019-10-24 00:00:00

  • Correlation between serum gastrin and cellular proliferation in Barrett's esophagus.

    abstract:BACKGROUND:Patients with Barrett's esophagus (BE) are commonly treated with proton-pump inhibitors (PPIs) to minimize the exposure of esophageal mucosa to stomach acid. However, the use of these medications can lead to significant hypergastrinemia in a subset of patients, which is concerning due to the known tumorigeni...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Green DA,Mlynarczyk CM,Vaccaro BJ,Capiak KM,Quante M,Lightdale CJ,Abrams JA

    更新日期:2011-03-01 00:00:00

  • Combined radiological-endoscopic management of difficult bile duct stones: 18-year single center experience.

    abstract:OBJECTIVES:Clinical evidence regarding radiological-endoscopic management of intrahepatic bile duct stones is currently lacking. Our aim is to report our 18-year experience in combined radiological-endoscopic management of intrahepatic difficult bile duct stones. METHODS:From June 1994 to June 2012, 299 symptomatic pa...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Cannavale A,Bezzi M,Cereatti F,Lucatelli P,Fanello G,Salvatori FM,Fanelli F,Fiocca F,Donatelli G

    更新日期:2015-11-01 00:00:00

  • Clinical outcome of patients with obscure gastrointestinal bleeding during antithrombotic drug therapy.

    abstract:Background:The clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) during antithrombotic drug therapy has not been fully investigated. Methods:Patients who underwent video capsule endoscopy (VCE) for the investigation of OGIB at Okayama University Hospital from January 2009 to March 2016 were en...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Kono Y,Kawano S,Okamoto Y,Obayashi Y,Baba Y,Sakae H,Abe M,Gotoda T,Inokuchi T,Kanzaki H,Iwamuro M,Kawahara Y,Okada H

    更新日期:2018-01-14 00:00:00

  • Clinical impact of dual red imaging in colorectal endoscopic submucosal dissection: a pilot study.

    abstract:BACKGROUND:Dual red imaging (DRI), a novel image-enhanced endoscopic technique, is expected to improve visibility of thin vessels, but no reports of the clinical use of DRI in colorectal endoscopic submucosal dissection (ESD) have been published. We aimed to compare the visibility of vessels, demarcation line between t...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Ninomiya Y,Oka S,Tanaka S,Hirano D,Sumimoto K,Tamaru Y,Asayama N,Shigita K,Nishiyama S,Hayashi N,Chayama K

    更新日期:2016-09-01 00:00:00

  • Hereditary pancreatitis for the endoscopist.

    abstract::Hereditary pancreatitis shares a majority of clinical and morphologic features with chronic alcoholic pancreatitis, but may present at an earlier age. The term hereditary pancreatitis has primarily been associated with mutations in the serine protease 1 gene (PRSS1) which encodes for cationic trypsinogen. PRSS1 mutati...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Patel MR,Eppolito AL,Willingham FF

    更新日期:2013-03-01 00:00:00

  • Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders.

    abstract::Functional gastrointestinal disorders, such as irritable bowel syndrome and functional dyspepsia, are complex conditions with multiple factors contributing to their pathophysiology. As a consequence they are difficult to treat and have posed significant challenges to the pharmaceutical industry when trying to develop ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Sanger GJ,Chang L,Bountra C,Houghton LA

    更新日期:2010-09-01 00:00:00

  • Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer.

    abstract::Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor immunity. Programmed death-1 (PD-1) and programmed death ligand-1 (...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Liu X,Yang Z,Latchoumanin O,Qiao L

    更新日期:2016-11-01 00:00:00

  • Targeting neutrophil extracellular traps in severe acute pancreatitis treatment.

    abstract::Severe acute pancreatitis (SAP) is a critical abdominal disease associated with high death rates. A systemic inflammatory response promotes disease progression, resulting in multiple organ dysfunction. The functions of neutrophils in the pathology of SAP have been presumed traditionally to be activation of chemokine a...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Hu J,Kang H,Chen H,Yao J,Yi X,Tang W,Wan M

    更新日期:2020-11-24 00:00:00

  • Automated endoscopic detection and classification of colorectal polyps using convolutional neural networks.

    abstract:Background:Recently the American Society for Gastrointestinal Endoscopy addressed the 'resect and discard' strategy, determining that accurate in vivo differentiation of colorectal polyps (CP) is necessary. Previous studies have suggested a promising application of artificial intelligence (AI), using deep learning in o...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Ozawa T,Ishihara S,Fujishiro M,Kumagai Y,Shichijo S,Tada T

    更新日期:2020-03-20 00:00:00

  • Bilio-pancreatic endoscopy during COVID-19 pandemic.

    abstract::On 31 December 2019, the WHO China Country Office was informed of cases of pneumonia of unknown etiology detected in Wuhan (Hubei Province of China). In January 2020, a new coronavirus named SARS-CoV2 was isolated and, since that time, SARS-CoV2 related disease (COVID-19) rapidly spread all over the world becoming pan...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Bove V,Schepis T,Boškoski I,Landi R,Orlandini B,Pontecorvi V,Familiari P,Tringali A,Perri V,Costamagna G

    更新日期:2020-06-24 00:00:00

  • Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews.

    abstract:Background:Pharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potenti...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Chu MHK,Wu IXY,Ho RST,Wong CHL,Zhang AL,Zhang Y,Wu JCY,Chung VCH

    更新日期:2018-07-16 00:00:00

  • Hepatocellular carcinoma: review of current treatment with a focus on targeted molecular therapies.

    abstract::The treatment of hepatocellular carcinoma (HCC) remains a challenge, with 1- and 3-year survival rates of 20% and 5%, respectively, and a median survival of 8 months. However, a better understanding of the pathogenesis of HCC, and advances in targeted molecular therapies provide physicians treating this disease with n...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Olsen SK,Brown RS,Siegel AB

    更新日期:2010-01-01 00:00:00

  • The changing landscape of hepatitis C virus therapy: focus on interferon-free treatment.

    abstract::Chronic hepatitis C (CHC) affects over 185 million individuals worldwide, approximately 3% of the world's population. CHC can lead to quality of life impairment, cirrhosis, hepatocellular carcinoma (HCC), liver failure and liver-related death. While CHC has been associated with increases in HCC, liver-related mortalit...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Lam BP,Jeffers T,Younoszai Z,Fazel Y,Younossi ZM

    更新日期:2015-09-01 00:00:00

  • Platelet-to-lymphocyte percentage ratio index: a simple non-invasive index to monitor the endoscopic activity in Crohn's disease.

    abstract:Background:Recent evidence has shown that the complete blood count (CBC) is abnormal in patients with Crohn's disease (CD). We aimed to investigate an effective CBC parameter and explore its impact on disease activity in a large CD cohort. Methods:We performed a retrospective analysis of patients with established CD w...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Chen R,Li L,Chao K,Hong M,Cao Q,Ye L,Zhou G,Fang X,Guo H,Cao X,Ye X,Zeng Z,Chen M,Zhang S

    更新日期:2020-12-21 00:00:00

  • The potential role of comprehensive genomic profiling to guide targeted therapy for patients with biliary cancer.

    abstract::Remarkable advancements in techniques of genomic profiling and bioinformatics have led to the accumulation of vast amounts of knowledge on the genomic profiles of biliary tract cancer (BTC). Recent largescale molecular profiling studies have not only highlighted genomic differences characterizing tumors of the intrahe...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Lee H,Ross JS

    更新日期:2017-06-01 00:00:00

  • Targeting mucosal healing in Crohn's disease: what the clinician needs to know.

    abstract::In recent years, mucosal healing has emerged as a key therapeutic goal in the clinical management of patients with Crohn's disease, as it has been associated with improved long-term clinical outcomes. With the vast improvements in endoscopic imaging techniques and the increase in available treatment options, which rep...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章,评审


    authors: Klenske E,Bojarski C,Waldner M,Rath T,Neurath MF,Atreya R

    更新日期:2019-06-14 00:00:00

  • Fully covered self-expandable metal stent in the treatment of postsurgical colorectal diseases: outcome in 29 patients.

    abstract:BACKGROUND:Self-expandable metal stent (SEMS) placement is a minimally invasive treatment for palliation of malignant colorectal strictures and as a bridge to surgery. However, the use of SEMS for benign colorectal diseases is controversial. The purpose of this retrospective study is to evaluate the efficacy and safety...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Cereatti F,Fiocca F,Dumont JL,Ceci V,Vergeau BM,Tuszynski T,Meduri B,Donatelli G

    更新日期:2016-03-01 00:00:00

  • Erratum for PMID 21180585.

    abstract::Erratum to 'Possible interactions between dietary fibres and 5-aminosalicyclic acid' by C Henriksen, S Hansen, I Nordgaard-Lassen, J Rikardt Anderson and P Madsen. Therapeutic Advances in Gastroenterology (2010) 3(1) 5-9 [DOI: 10.1177/ 1756283X09347810][This corrects the article on p. 5 in vol. 3.]. ...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 已发布勘误



    更新日期:2012-09-01 00:00:00

  • Repeat treatment with rifaximin improves irritable bowel syndrome-related quality of life: a secondary analysis of a randomized, double-blind, placebo-controlled trial.

    abstract:BACKGROUND:Diarrhea-predominant irritable bowel syndrome (IBS-D) impairs patient quality of life (QOL). Rifaximin is an oral, nonsystemic antibiotic indicated for IBS-D. The objective of this secondary analysis was to evaluate rifaximin retreatment on IBS-related QOL in patients with IBS-D. METHODS:Patients received o...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Cash BD,Pimentel M,Rao SSC,Weinstock L,Chang L,Heimanson Z,Lembo A

    更新日期:2017-09-01 00:00:00

  • Immunogenicity of biologics in inflammatory bowel disease.

    abstract::Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Treatment options include biologic therapies; however, a proportion of patients lose response to biologics, partly due to the formation of anti-drug antibodies (ADAbs). Concomitant immunosuppressive agents reduce t...

    journal_title:Therapeutic advances in gastroenterology

    pub_type: 杂志文章


    authors: Vermeire S,Gils A,Accossato P,Lula S,Marren A

    更新日期:2018-01-21 00:00:00