2009 H1N1 fatalities: the New Mexico experience.

Abstract:

:Histopathologic features of New Mexico 2009 H1N1 fatalities have not been representative of those reported nationwide. We retrospectively reviewed medical records of all New Mexico 2009 pandemic influenza A (pH1N1) fatalities (n = 50). In cases in which autopsy was performed (n = 12), histologic sections and culture results were examined. In contrast to previously published studies, the majority of our fatalities did not have diffuse alveolar damage (DAD) (2/12; 16.7%). Common findings included pulmonary interstitial inflammation and edema, tracheobronchitis, and pneumonia. Two cases had significant extra-pulmonary manifestations: myocarditis and cerebral edema with herniation. The majority had a rapid disease course: range from 1 to 12 days (median, 2 days), and Native Americans were disproportionately represented among fatalities. These findings suggest that New Mexico H1N1 fatalities generally did not survive long enough to develop the classic picture of DAD. Pathologists should be aware that H1N1 may cause extra-pulmonary pathology and perform postmortem cultures and histologic sampling accordingly.

journal_name

J Forensic Sci

authors

Brooks EG,Bryce CH,Avery C,Smelser C,Thompson D,Nolte KB

doi

10.1111/j.1556-4029.2012.02163.x

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

1512-8

issue

6

eissn

0022-1198

issn

1556-4029

journal_volume

57

pub_type

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