Restorative neurology: consideration of the new anatomy and physiology of the injured nervous system.

Abstract:

:The adult human nervous system is an incredibly complex set of thousands to tens of thousands of connections between a hundred billion neurons that develops via an intricate spatial-temporal process and is shaped by experience. In addition, any one anatomical arrangement of neural circuits is usually capable of multiple physiological states. Following neurological injury, a new anatomy, and consequently a new spectrum of physiology, emerges within this nervous system with its mix of both injured and uninjured parts. It is this new combination of neural components that determines the extent to which natural functional recovery can occur and the extent to which clinical interventions can further that recovery. Detecting the new anatomy and physiology of the injured human nervous system is difficult but not impossible and some methods can track over time changes in neural structure or, more often, functions that correlate with neurological improvement. The goal of restorative neurology is to make best use of this new anatomy and physiology to facilitate neurological recovery. While we are still learning about how neurorehabilitation interventions generate functional recovery, we can begin to test hypothesis regarding the underlying mechanisms of neural plasticity and attempt to augment those processes.

journal_name

Clin Neurol Neurosurg

authors

Tansey KE,McKay WB,Kakulas BA

doi

10.1016/j.clineuro.2012.01.010

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

436-40

issue

5

eissn

0303-8467

issn

1872-6968

pii

S0303-8467(12)00022-4

journal_volume

114

pub_type

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