Oxygen metabolism, oxygen extraction and positron emission tomography: Historical perspective and impact on basic and clinical neuroscience.

Abstract:

:Oxygen utilization is central to the human brain's high metabolic rate. Measurement of this fundamental process, in both disease and health, has been a focus of research attention over the last 35 years. This review plots the course of the use of oxygen-15 to study regional cerebral oxygen extraction and metabolism using Positron Emission Tomography (PET) in disease and in health. The scientific discoveries and resulting conceptual changes to both basic and clinical neuroscience, as well as the new methodological approaches brought about by this area of research, are also summarized. We conclude with a brief overview of the current status of oxygen-15 PET in neuroscience, along with our visions for future developments and applications.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Baron JC,Jones T

doi

10.1016/j.neuroimage.2011.12.036

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

492-504

issue

2

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(11)01438-8

journal_volume

61

pub_type

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