Abstract:
:Oxygen utilization is central to the human brain's high metabolic rate. Measurement of this fundamental process, in both disease and health, has been a focus of research attention over the last 35 years. This review plots the course of the use of oxygen-15 to study regional cerebral oxygen extraction and metabolism using Positron Emission Tomography (PET) in disease and in health. The scientific discoveries and resulting conceptual changes to both basic and clinical neuroscience, as well as the new methodological approaches brought about by this area of research, are also summarized. We conclude with a brief overview of the current status of oxygen-15 PET in neuroscience, along with our visions for future developments and applications.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Baron JC,Jones Tdoi
10.1016/j.neuroimage.2011.12.036subject
Has Abstractpub_date
2012-06-01 00:00:00pages
492-504issue
2eissn
1053-8119issn
1095-9572pii
S1053-8119(11)01438-8journal_volume
61pub_type
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