Abstract：
:Neural networks for the processing of appetitive and aversive information, in isolation, have been well characterized. However, how the brain integrates competing signals associated with simultaneous appetitive and aversive information is less clear. In particular, it is unknown how the presence of concurrent reward modulates the processing of an aversive event throughout the brain. Here, we utilized a four-armed bandit task in an fMRI study to measure the representation of an aversive electric shock with and without the simultaneous receipt of monetary reward. Using a region of interest (ROI) approach, we first identified regions activated by the experience of aversive electric shock, and then measured how this shock-related activation is modulated by concurrent reward using independent data. Informed by prior literature and our own preliminary data, analyses focused on the dorsolateral prefrontal cortex, anterior and posterior insula, anterior cingulate cortex, and the thalamus and somatosensory cortex. We hypothesized that the neural response to punishment in these ROIs would be attenuated by the presence of concurrent reward. However, we found no evidence of concurrent reward attenuating the neural response to punishment in any ROI and also no evidence of concurrent punishment attenuating the neural response to reward in exploratory analyses. Altogether, our findings are consistent with the idea that neural networks responsible for the processing of reward and punishment signals are largely independent of one another, and that representations of overall value or utility are arrived at through the integration of separate reward and punishment signals at later stages of information processing.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Kim AJ,Anderson BAdoi
10.1016/j.neuroimage.2020.116890subject
Has Abstractpub_date
2020-08-15 00:00:00pages
116890eissn
1053-8119issn
1095-9572pii
S1053-8119(20)30376-1journal_volume
217pub_type
杂志文章相关文献
NEUROIMAGE文献大全abstract：:Depression is one of the leading causes of disability worldwide. Immense heterogeneity in symptoms of depression causes difficulty in diagnosis, and to date, there are no established biomarkers or imaging methods to examine depression. Unpredictable chronic mild stress (CMS) induced anhedonia is considered to be a rea...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.07.001
更新日期：2016-11-15 00:00:00
abstract：UNLABELLED:The brainstem contains various important monoaminergic neuronal centers, including the raphe nuclei which contain serotonergic neurons. The raphe nuclei, however, are not easily identifiable and located by conventional neuroimaging. METHODS:Fluorodeoxyglucose positron emission tomography (PET) and magnetic ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.09.036
更新日期：2012-01-16 00:00:00
abstract：:Previous studies have shown that individuals with overweight and obesity may experience attentional biases and reduced inhibition toward food stimuli. However, evidence is scarce as to whether the attentional bias is present even before stimuli are consciously recognized. Moreover, it is not known whether or not diffe...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2021.117725
更新日期：2021-01-20 00:00:00
abstract：:Economic decision-making involves the weighting of magnitude and probability of potential gains/losses. While previous work has examined the neural systems involved in decision-making, there is a need to understand how the parameters associated with decision-making (e.g., magnitude of expected reward, probability of e...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2008.08.016
更新日期：2009-01-15 00:00:00
abstract：:Seventeen clinically stabilized monohemispheric stroke patients were studied in order to investigate the chronic topographical modifications induced on primary sensory cortical hand areas by a monohemispheric stroke within the middle cerebral artery territory. Magnetoencephalographic (MEG) localization of the cortical...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1006/nimg.2000.0686
更新日期：2001-08-01 00:00:00
abstract：:Cast shadows can be salient depth cues in three-dimensional (3D) vision. Using a motion illusion in which a ball is perceived to roll in depth on the bottom or to flow in the front plane depending on the slope of the trajectory of its cast shadow, we investigated cortical mechanisms underlying 3D vision based on cast ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.07.075
更新日期：2011-01-01 00:00:00
abstract：:Tool use is one of the most remarkable skills of the human species, enabling complex interactions with the environment. To establish such interactions, we predict the sensory consequences of our actions based on a copy of the motor command (efference copy), leading to an attenuated perception and neural suppression of...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116309
更新日期：2020-02-01 00:00:00
abstract：:Traumatic brain injury (TBI) is one of the most common causes of long-term disability. Despite the importance of identifying neuropathology in individuals with chronic TBI, methodological challenges posed at the stage of inter-subject image registration have hampered previous voxel-based MRI studies from providing a c...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.10.005
更新日期：2008-02-01 00:00:00
abstract：:Sex hormones and the serotonergic system interact in the regulation of mood, learning, memory and sexual behaviour. However, the mechanisms have not been fully explored. The serotonin transporter protein (5-HTT) regulates synaptic concentrations of serotonin and is a primary target for selective serotonin reuptake inh...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2014.11.003
更新日期：2015-02-01 00:00:00
abstract：:Extracellular β-amyloid (Aβ) plaque deposits and inflammatory immune activation are thought to alter various aspects of tissue microstructure, such as extracellular free water, fractional anisotropy and diffusivity, as well as the density and geometric arrangement of axonal processes. Quantifying these microstructural...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2019.116138
更新日期：2019-11-15 00:00:00
abstract：:Cerebral hypoperfusion elevates the risk of brain white matter (WM) lesions and cognitive impairment. Central artery stiffness impairs baroreflex, which controls systemic arterial perfusion, and may deteriorate neuronal fiber integrity of brain WM. The purpose of this study was to examine the associations among brain ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2015.01.041
更新日期：2015-04-15 00:00:00
abstract：:Gaining new insights into the anatomy of the human hypothalamus is crucial for the development of new treatment strategies involving functional stereotactic neurosurgery. Here, using anatomical comparisons between histology and magnetic resonance images of the human hypothalamus in the coronal plane, we show that disc...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.07.013
更新日期：2012-01-02 00:00:00
abstract：:The cortical microvessels are organized in an intricate, hierarchical, three-dimensional network. Superimposed on this anatomical complexity is the highly complicated signaling that drives the focal blood flow adjustments following a rise in the activity of surrounding neurons. The microvascular response to neuronal a...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.01.011
更新日期：2013-05-01 00:00:00
abstract：:In this work, we investigated the use of real-time functional magnetic resonance imaging (fMRI) with neurofeedback training (NFT) to teach volitional down-regulation of the auditory cortex (AC) using directed attention strategies as there is a growing interest in the application of fMRI-NFT to treat neurologic disorde...
journal_title：NeuroImage
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroimage.2019.03.078
更新日期：2019-07-15 00:00:00
abstract：:Multiecho T(2) relaxation measurements offer specific information about myelin content through the myelin water fraction (MWF), as well as about the water environments through the intra- and extra-cellular (IE), and global, geometric mean T(2) (GMT(2)) times. While these measurements have yielded new insights into bra...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2010.08.076
更新日期：2011-01-15 00:00:00
abstract：:High-resolution diffusion MRI can provide the ability to resolve small brain structures, enabling investigations of detailed white matter architecture. A major challenge for in vivo high-resolution diffusion MRI is the low signal-to-noise ratio. In this work, we combine two highly compatible methods, ultra-high field ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.08.054
更新日期：2016-12-01 00:00:00
abstract：:Chronic stress in non-human animals decreases the volume of the hippocampus, a brain region that supports learning and memory and that regulates neuroendocrine activity. In humans with stress-related psychiatric syndromes characterized by impaired learning and memory and dysregulated neuroendocrine activity, surrogate...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2006.10.045
更新日期：2007-04-01 00:00:00
abstract：:Salient stimuli are characterized by their capability to perturb and seize available cognitive resources. Although the striatum and its dopaminergic inputs respond to a variety of stimuli categorically defined as salient, including rewards, the relationship between striatal activity and saliency is not well understood...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2005.08.006
更新日期：2006-02-01 00:00:00
abstract：:We established a strategy to perform cross-validation of serial optical coherence scanner imaging (SOCS) and diffusion tensor imaging (DTI) on a postmortem human medulla. Following DTI, the sample was serially scanned by SOCS, which integrates a vibratome slicer and a multi-contrast optical coherence tomography rig fo...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.06.032
更新日期：2014-10-15 00:00:00
abstract：:Visual information processing involves the integration of stimulus and goal-driven information, requiring neuronal communication. Gamma synchronisation is linked to neuronal communication, and is known to be modulated in visual cortex both by stimulus properties and voluntarily-directed attention. Stimulus-driven modu...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.04.108
更新日期：2013-10-01 00:00:00
abstract：:Although numbers carry averbal semantics (i.e., magnitude), they are often utilized in verbal Working Memory (vWM) tasks. However, vWM is thought to rely on a purely phonological code. Here, we tested the influence of (a) averbal semantics and (b) different tasks on performance in a vWM context by examining stimulus a...
journal_title：NeuroImage
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuroimage.2005.07.009
更新日期：2006-01-01 00:00:00
abstract：:The amygdala (AMG) has been repeatedly implicated in the processing of threatening and negatively valenced stimuli and multiple fMRI paradigms have reported personality, genetic, and psychopathological associations with individual differences in AMG activation in these paradigms. Yet the interchangeability of activati...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2016.11.038
更新日期：2017-02-01 00:00:00
abstract：:It is well established that the time to name target objects can be influenced by the presence of categorically related versus unrelated distractor items. A variety of paradigms have been developed to determine the level at which this semantic interference effect occurs in the speech production system. In this study, w...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.12.067
更新日期：2010-04-01 00:00:00
abstract：:Schippers, Renken and Keysers (NeuroImage, 2011) present a simulation of multi-subject lag-based causality estimation. We fully agree that single-subject evaluations (e.g., Smith et al., 2011) need to be revisited in the context of multi-subject studies, and Schippers' paper is a good example, including detailed multi...
journal_title：NeuroImage
pub_type： 评论,杂志文章
doi：10.1016/j.neuroimage.2011.08.015
更新日期：2012-01-16 00:00:00
abstract：:Imaging biomarkers derived from magnetic resonance imaging (MRI) data are used to quantify normal development, disease, and the effects of disease-modifying therapies. However, motion during image acquisition introduces image artifacts that, in turn, affect derived markers. A systematic effect can be problematic since...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2014.12.006
更新日期：2015-02-15 00:00:00
abstract：:The goal of the MEG study was to investigate the influence of tumor treatment on pathological delta activity (1-4 Hz). The treatment consisted of neurosurgery, and in some of the patients, additional radiotherapy. MEG and MR recordings were made both before and after the treatment in 17 patients. The signal power in t...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2003.07.030
更新日期：2003-12-01 00:00:00
abstract：:Connectivity and network analysis in neuroscience has been applied to multiple spatial scales, but the links between these different scales have rarely been investigated. In tumor-related epilepsy, altered network topology is related to behavior, but the molecular basis of these observations is unknown. We elucidate t...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2013.02.067
更新日期：2013-07-15 00:00:00
abstract：:The purpose of this study is to determine regions of cerebral cortex activated during the onset and propagation of dense array electroencephalographic (dEEG) epileptiform discharges in patients with juvenile myoclonic epilepsy (JME), through the use of 256 channel, dense array scalp EEG recordings. Ten patients (16-58...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2009.08.004
更新日期：2010-01-01 00:00:00
abstract：:Our goal is to study the human brain anatomical network. For this, the anatomical connection probabilities (ACP) between 90 cortical and subcortical brain gray matter areas are estimated from diffusion-weighted Magnetic Resonance Imaging (DW-MRI) techniques. The ACP between any two areas gives the probability that tho...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2007.10.060
更新日期：2008-04-15 00:00:00
abstract：:Connectivity analyses have become increasingly important in functional imaging. When used to describe the functional anatomy of a specific behavior, these analyses are generally applied to a subset of the data that demonstrate significant differences when experimental conditions are contrasted. Such data reduction is ...
journal_title：NeuroImage
pub_type： 杂志文章
doi：10.1016/j.neuroimage.2011.09.037
更新日期：2012-02-01 00:00:00
