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Structural and cognitive deficits in remitting and non-remitting recurrent depression: a voxel-based morphometric study.

Abstract：

:Remission is the optimal outcome for major depressive disorder (MDD), but many patients do not improve appreciably despite treatment with medication. Treatment-resistant patients may experience deterioration in cognitive functions. Research has reported structural abnormalities in certain brain areas that may contribute to a poor clinical response. We hypothesize that there will be structural differences between patients able to achieve remission and those responding poorly to antidepressants. In the first voxel-based morphometric (VBM) study comparing remitting with non-remitting MDD, we investigated gray matter volume (GMV) differences between depressives to determine which structural abnormalities existed, and correlated these with diminished cognitive functioning. Of 44 adults with recurrent MDD, 19 had full remissions and 25 were non-remitters after a 6-week trial with antidepressant treatment. Remission was defined by 17-item Hamilton Depression Rating Scale scores of

journal_name

Neuroimage

journal_title

NeuroImage

authors

Li CT,Lin CP,Chou KH,Chen IY,Hsieh JC,Wu CL,Lin WC,Su TP

doi

10.1016/j.neuroimage.2009.11.021

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

347-56

issue

1

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(09)01205-1

journal_volume

50

pub_type

杂志文章

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