Abstract:
AIM:To determine diagnostic rate, complications and patient tolerability of endobronchial ultrasound-guide sheath (EBUS-GS) and computed tomography (CT)-guided percutaneous core biopsy for peripheral lung lesions. METHODS:Lesions >1 cm diameter on CT were randomised to either EBUS-GS or CT-guided biopsy. Excluded were patients with severe chronic obstructive airway disease, lesions touching visceral pleura or hilum, and patients with symptoms needing bronchoscopic evaluation. Patients completed preprocedure and postprocedure questionnaires on tolerability. RESULTS:Of 64 participants (mean lesion size 29 ± 16 mm), 57 completed the study. Diagnostic sensitivity was 67% for EBUS-GS and 78% for CT-guided biopsy (P = not significant). In those with negative results, in the EBUS group, nine had a CT-guided biopsy as a cross-over, seven of which were positive. In the CT group, four had cross-over EBUS-GS of which three were diagnostic. Sensitivity for malignancy was 17/23 for EBUS-GS (74%) and 23/26 (88%, P = not significant). For lesions <2 cm, CT-guided biopsy had a significantly better diagnostic yield (80% vs 50%, P = 0.05). In EBUS-GS cases, for lesions with an air bronchogram, sensitivity was 89%. Pneumothorax and intercostal catheter insertion occurred in three and two cases, respectively, for EBUS, and 10 and 3 cases for CT-guided biopsy (P = 0.02 for pneumothorax). Nine unexpected admissions occurred after CT-guided biopsy compared with three after EBUS-GS. Overall, tolerability was high for both groups; however three patients had moderate-to-severe pain after CT-guided biopsy. CONCLUSIONS:In lesions <2 cm, CT-guided biopsy had higher yields; however, EBUS-GS had better tolerability and fewer complications.
journal_name
Intern Med Jjournal_title
Internal medicine journalauthors
Fielding DI,Chia C,Nguyen P,Bashirzadeh F,Hundloe J,Brown IG,Steinke Kdoi
10.1111/j.1445-5994.2011.02707.xsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
894-900issue
8eissn
1444-0903issn
1445-5994journal_volume
42pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) is a subgroup of oncogene addicted lung cancer that predicts response to tyrosine kinase inhibitors (TKI). However, there is variability in response and survival outcomes in patients with EGFR mutation treated with TKI. AIM:T...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13555
更新日期:2017-12-01 00:00:00
abstract:AIMS:Our primary aim was to determine the rate of overseas travel in immunocompromised individuals attending appropriate clinics at an Australian tertiary care hospital. We also aimed to characterise health-seeking behaviour prior to travel and investigated sources of pre-travel advice, compared travel patterns and act...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12753
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Type 2 diabetes (T2D) in young adults is associated with a high risk of diabetes complications. AIMS:To investigated the demography and the emergence of complications of young adults with T2D in the central Auckland region where there has been substantial immigration. METHODS:In total, 310 young adults wit...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13623
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND: According to the International Prognostic Scoring System (IPSS), sole +8 is categorized as intermediate cytogenetic subgroup. But as some myelodysplastic syndrome (MDS) patients with +8 perhaps progress quickly to acute leukaemia and have shorter survival, some reports have suggested that +8 should be cate...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.02061.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:The relationship between serum triglycerides (TG) level and the risk of coronary heart disease (CHD) mortality remains controversial. AIMS:To evaluate whether TG level is a risk factor for CHD in elderly people from general population, and to look for interactions between TG and other risk factors. METHODS...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2005.00940.x
更新日期:2005-10-01 00:00:00
abstract::ABSTRACT Treatment of invasive fungal infections is increasingly complex. Amphotericin B deoxycholate has long been the mainstay of treatment. However, there has been increasing recognition of both the propensity for nephro-toxicity in haematology, transplant and intensive care patients as well as its adverse impact o...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1444-0903.2004.00541.x
更新日期:2004-04-01 00:00:00
abstract::The Australian National Chronic Obstructive Pulmonary Disease (COPD) guidelines recommend that inhaled corticosteroids (ICS) be reserved for patients with a post-bronchodilator forced expiratory volume in 1 s (FEV1 ) less than 50% predicted and those who experience ≥2 exacerbations in 12 months. In total, 707 COPD pat...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13611
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:The reported risk of depression in patients with hypomagnesaemia is controversial. AIM:The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS:A literature search was performed using MEDLINE, EMBASE, Cochrane Database and clinicaltrials.gov from inc...
journal_title:Internal medicine journal
pub_type: 杂志文章,meta分析,评审
doi:10.1111/imj.12682
更新日期:2015-04-01 00:00:00
abstract:AIMS:To measure factors associated with underuse of beta-blocker therapy after myocardial infarction (MI). METHODS:The Newcastle and Perth collaborating centres of the World Health Organization (WHO) MONICA project (to MONItor trends and determinants of Cardiovascular disease) systematically evaluated all patients adm...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2001.00098.x
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Several epidemiological studies have suggested a positive association of coronary heart disease with both Helicobacter pylori and Chlamydia pneumoniae infection. The issue has been difficult to resolve because of the potential impact of several confounding factors, in particular, socioeconomic status for H. ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1046/j.1445-5994.2003.00349.x
更新日期:2003-07-01 00:00:00
abstract::Bronchiectasis is generally classified into cystic fibrosis and non-cystic fibrosis bronchiectasis. This review article describes non-cystic fibrosis bronchiectasis in adults. Bronchiectasis can be considered a heterogeneous condition characterized by irreversible airway dilatation with chronic bronchial infection/inf...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2006.01219.x
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:Glomerular M-type phospholipase A2 receptor (PLA2 R) is important for diagnosing idiopathic membranous nephropathy (IMN). The relation between glomerular PLA2 R expression and response to treatment remains to be explored. AIMS:We conducted the study to explore the positive rate and clinical significance of ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13233
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Exacerbations requiring hospital admission for chronic obstructive pulmonary disease (COPD) contribute to a decline in health status and are costly to the community. Long-term trends in admissions and associated outcomes are difficult to establish because of frequent readmissions, high case fatality and pote...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01240.x
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Early involvement of palliative care and advance care planning improves quality of life outcomes and survival for patients with advanced lung cancer, however there are barriers to implementation. AIMS AND METHODS:A single-centre prospective audit reviewing "Goals of Care" (GOC) form completion and palliativ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14817
更新日期:2020-03-23 00:00:00
abstract::Autoimmune inflammatory rheumatic diseases (AIIRD), such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis are often complicated by infection, which results in significant morbidity and mortality. The increased risk of infection is probably due to a combination of immunosuppressive effects of the...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.13371
更新日期:2017-05-01 00:00:00
abstract:AIMS:Low molecular weight heparins (LMWH) permit safe and effective treatment of uncomplicated deep venous thrombosis (DVT) at home. The aim of this study was to evaluate the cost minimization, cost shifting and patient satisfaction associated with at-home DVT treatment using the LMWH enoxaparin, compared to standard i...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::Neuroimaging in dementia has focused on documenting any burden of vascular disease or excluding any reversible intracranial pathology. We review the use of computed tomography to examine for medial temporal lobe atrophy in dementia and compare this with a case series of such measurements from our memory clinic. Measur...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2007.01598.x
更新日期:2008-02-01 00:00:00
abstract::Advanced heart failure represents a small proportion of patients with heart failure that possess high-risk features associated with high hospital readmission rates, significant functional impairment and mortality. Identification of those who have progressed to, or are near a state of advanced heart failure should prom...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12817
更新日期:2016-05-01 00:00:00
abstract::Undiagnosed pheochromocytoma in pregnancy is associated with significant maternal and foetal mortality. Herein we reviewed five cases of pheochromocytoma in pregnancy occurring during late pregnancy. The mean age at presentation was 30.6 years, and the gestational age ranged from 26 to 36 weeks. All patients had eleva...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12118
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Advance care planning (ACP) provides patients with the ability to make their decisions known about how they would like to be treated if they lose capacity. Medical practitioners have a key role to play in providing information on ACP to their patients. This research explores their knowledge and attitudes to ...
journal_title:Internal medicine journal
pub_type: 杂志文章,随机对照试验
doi:10.1111/imj.12354
更新日期:2014-03-01 00:00:00
abstract::We hereby present two case reports of moderate coronavirus disease patients, suffering from profound hypoxaemia, further deteriorating later on. A schedule pre-planned awake prone position manoeuvres were executed during their hospital stay. Following this, the patients' saturation improved, later to be weaned from ox...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14926
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Advanced training in gastroenterology currently consists of 2 years of core training and 1 elective (non-core) year. We surveyed gastroenterologists 2-7 years following completion of training to determine the strengths and weaknesses of their training. METHODS:All gastroenterologists were invited to partici...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2012.02757.x
更新日期:2013-04-01 00:00:00
abstract::During a pandemic when hospitals are stretched and patients need isolation, the role of hospital-in-the-home (HITH) providing acute medical care at home has never been more relevant. We aimed to define and address the challenges to acute home care services posed by the COVID-19 pandemic. Planning for service operation...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.15011
更新日期:2020-10-01 00:00:00
abstract::The negative health effects of the 2003 invasion of Iraq should act as a watershed in the medical profession's approach to violent conflict. ...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2007.01319.x
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The NSW Clinical Excellence commission introduced the "Between the Flags" program in response to the death of a young patient as a system wide approach for early detection and management of the deteriorating patient in all 242 NSW hospitals. The impact of BTF implementation on the 35 larger hospitals with IC...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.14812
更新日期:2020-03-04 00:00:00
abstract::Clarithromycin is the most documented cytochrome P450 3A4 (CYP3A4) inhibitor to cause an adverse interaction with simvastatin. This particular case is of interest as rhabdomyolysis only occurred after an increase in the dose of clarithromycin. The patient developed raised cardiac biomarkers without any obvious cardiac...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.12464
更新日期:2014-07-01 00:00:00
abstract::Extramedullary haemopoiesis (EMH) is a complication commonly associated with beta-thalassaemia intermedia; it is frequently asymptomatic but can sometimes lead to symptomatic tumour-like masses. No guidelines or common consensus are available in literature regarding the different treatment strategies and only single c...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/imj.12386
更新日期:2014-04-01 00:00:00
abstract::It has been stated that academic medicine is in a worldwide crisis. Is this decline in hospital academic practice a predictable consequence of modern clinical practice with its emphasis on community and outpatient-based services as well as a corporate health-care ethos or does it relate to innate problems in the train...
journal_title:Internal medicine journal
pub_type: 杂志文章,评审
doi:10.1111/j.1445-5994.2007.01490.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Bali, Indonesia, presents significant infectious and non-infectious health risks for Australian travellers. Understanding this spectrum of illnesses has the potential to assist clinicians in evaluating unwell returning travellers and guide provision of pre-travel advice. AIM:To describe the spectrum of illn...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/imj.13993
更新日期:2019-01-01 00:00:00
abstract:AIM:Bigge Park Centre (BPC) is a sexual health clinic located in a socially disadvantaged area in Southwest Sydney. This served as a retrospective clinical audit, documenting patient demographics, identifying factors associated with virological, immunological and discordant responses, evaluating the centre's ability in...
journal_title:Internal medicine journal
pub_type: 杂志文章
doi:10.1111/j.1445-5994.2009.01983.x
更新日期:2010-04-01 00:00:00