14-aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity.

abstract：:Lens epithelial cells are the metabolic unit of the lens and antioxidant enzymes are mainly concentrated here. The purpose of this study was to maintain human lens epithelial cells (HLEC) in culture and examine the status of antioxidant enzymes (glutathione peroxidase (GSHPx), catalase (CAT), glutathione-S-transferase...

journal_title：Molecular and cellular biochemistry

authors： Mohanty I,Joshi S,Trivedi D,Srivastava S,Tandon R,Gupta SK

更新日期：2002-09-01 00:00:00

abstract：:The size distribution of lysosomes was determined in kidney proximal tubule cells of two mouse pigment mutants, pale ear and pallid, which have an increase in kidney lysosomal enzyme content caused by a decreased rate of secretion of lysosomal enzymes into urine. Both mutations have larger lysosomes when compared with...

journal_title：Molecular and cellular biochemistry

authors： Piccini AE,Jahreis GP,Novak EK,Swank RT

更新日期：1980-06-18 00:00:00

abstract：:Angiotensin II has previously been reported to have in vivo and in vitro cardiac hypertrophic effects. We used the salt-sensitive Dahl rat genetic strain to separate mechanical (pressure overload) vs. hormonal (renin-angiotensin system) input in cardiac hypertrophy. Blood pressure was significantly increased and left ...

journal_title：Molecular and cellular biochemistry

authors： Peeler TC,Baker KM,Esmurdoc CF,Chernin MI

更新日期：1991-05-29 00:00:00

abstract：:The present study was aimed to delineate in vivo mechanisms of orally administered fisetin with special reference to mitochondrial dysfunction in lung tissues employing benzo(a)pyrene (B(a)P) as the model lung carcinogen. The recent revival of interest in the study of mitochondria has been stimulated by the evidence t...

journal_title：Molecular and cellular biochemistry

authors： Ravichandran N,Suresh G,Ramesh B,Manikandan R,Choi YW,Vijaiyan Siva G

更新日期：2014-05-01 00:00:00

abstract：:Pre-steady-state and steady-state kinetics for the p.p. elastase-catalysed hydrolysis of ZAlaONp, one of the most favourable substrates for this serine protease, have been studied between pH 4.0 and 8.0. The results are consistent with the minimum three-step mechanism: (formula; see text) Under pre-steady-state condit...

journal_title：Molecular and cellular biochemistry

authors： Ascenzi P,Menegatti E,Guarneri M,Antonini E

更新日期：1983-01-01 00:00:00

abstract：:In vivo administration of pyridine has been shown to increase the activity and content of several forms of cytochrome P450 by transcriptional and posttranscriptional mechanisms. The effect of pyridine on CYP1A and CYP2E1 isozymes was studied in a rat hepatocyte culture model. Hepatocytes were isolated from non-induced...

journal_title：Molecular and cellular biochemistry

authors： Wu D,Ramin SA,Cederbaum AI

更新日期：1997-08-01 00:00:00

abstract：:Though, it is quite well-known how retinoic acid (RA) is able to induce neuritogenesis in different in vitro models, the putative role exerted by reactive oxygen species (ROS) during this process still need to be further studied. For such purpose, we used a neuronal-like cell line (SH-SY5Y cells) in order to investiga...

journal_title：Molecular and cellular biochemistry

authors： da Frota Junior ML,Pires AS,Zeidán-Chuliá F,Bristot IJ,Lopes FM,de Bittencourt Pasquali MA,Zanotto-Filho A,Behr GA,Klamt F,Gelain DP,Moreira JC

更新日期：2011-12-01 00:00:00

abstract：:A major component of the soluble fraction of rat heart is a homopolymer (Mr about 400-650 k) of a small protein (Mr about 20 k). This cardiac protein, which is highly homologous to alpha-B-crystallin, was isolated in its native state and visualized by electron microscopy. A homogeneous population of globular particles...

journal_title：Molecular and cellular biochemistry

authors： Longoni S,Lattonen S,Bullock G,Chiesi M

更新日期：1990-09-21 00:00:00

abstract：:Changes in fatty acid composition of myocardial lipids were examined in rats with heart failure following myocardial infarction. Left ventricular systolic pressure (LVSP) was decreased and left ventricular end-diastolic pressure (LVEDP) was elevated 24 h, 1 and 12 weeks after left coronary artery ligation (CAL), sugge...

journal_title：Molecular and cellular biochemistry

authors： Nasa Y,Sakamoto Y,Sanbe A,Sasaki H,Yamaguchi F,Takeo S

更新日期：1997-11-01 00:00:00

abstract：:It has been established that diabetes results in a cardiomyopathy, and increasing evidence suggests that an altered substrate supply and utilization by cardiac myocytes could be the primary injury in the pathogenesis of this specific heart muscle disease. For example, in diabetes, glucose utilization is insignificant,...

journal_title：Molecular and cellular biochemistry

authors： Rodrigues B,Cam MC,McNeill JH

更新日期：1998-03-01 00:00:00

abstract：:The antioxidant efficacy of vitamin E on Perchloroethylene (PER) induced cytotoxicity has been studied in rats. Feeding PER to rats for 42 days using sesame oil as vehicle alters total protein and protein bound carbohydrate components in liver and kidney of experimental animals. Supplementation of vitamin E prevented ...

journal_title：Molecular and cellular biochemistry

authors： Ebrahim AS,Gopalakrishnan R,Murugesan A,Sakthisekaran D

更新日期：1995-03-09 00:00:00

abstract：:One of the atrial natriuretic factor (ANF) receptors is a 180 kDa protein (180 kDa mGC) which possesses the extraordinary characteristic of being bifunctional: it is both a receptor and a guanylate cyclase. In addition to the 180 kDa mGC, there exists another 120-130 kDa protein which is also bifunctional and a 120 kD...

journal_title：Molecular and cellular biochemistry

authors： Marala RB,Sharma RK

更新日期：1992-01-15 00:00:00

abstract：:A number of quite specific and fairly potent inhibitors of protein kinase CK2, belonging to the classes of condensed polyphenolic compounds, tetrabromobenzimidazole/triazole derivatives and indoloquinazolines are available to date. The structural basis for their selectivity is provided by a hydrophobic pocket adjacent...

journal_title：Molecular and cellular biochemistry

authors： Sarno S,Ruzzene M,Frascella P,Pagano MA,Meggio F,Zambon A,Mazzorana M,Di Maira G,Lucchini V,Pinna LA

更新日期：2005-06-01 00:00:00

abstract：:MNSFβ, a ubiquitin-like protein, covalently binds to various target proteins including proapoptotic Bcl-G. During the course of isolation of MNSFβ-conjugating enzyme(s), we identified a novel target protein for MNSFβ. MALDI-TOF MS fingerprinting revealed that the MNSFβ-interacting protein is HSPA8 (heat shock 70-kDa p...

journal_title：Molecular and cellular biochemistry

authors： Notsu K,Nakagawa M,Nakamura M

更新日期：2016-10-01 00:00:00

abstract：:The purpose of this investigation was to determine whether fibronectin preparations from both chicken plasma and cell surface of fibroblasts can promote phagocytosis of gelatin-coated latex particles. Chicken plasma fibronectin was isolated (a) by ammonium sulfate fractionation, chromatography on Sepharose-4B followed...

journal_title：Molecular and cellular biochemistry

authors： Marquette D,Molnar J,Yamada K,Schlesinger D,Darby S,Van Alten P

更新日期：1981-05-26 00:00:00

abstract：:p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. We investigated the role of p90RSK in lung adenocarcinomas and whether the inhibition of p90RSK...

journal_title：Molecular and cellular biochemistry

authors： Abdulrahman N,Jaballah M,Poomakkoth N,Riaz S,Abdelaziz S,Issa A,Mraiche F

更新日期：2016-07-01 00:00:00

abstract：:NF45, also referred to as nuclear factor of activated T cells, has been reported to promote the progression of multiple cancer types. However, the expression and physiological significance of NF45 in pancreatic ductal adenocarcinoma (PDAC) remain largely elusive. In this study, we investigated the clinical relevance a...

journal_title：Molecular and cellular biochemistry

authors： Wan C,Gong C,Ji L,Liu X,Wang Y,Wang L,Shao M,Yang L,Fan S,Xiao Y,Wang X,Li M,Zhou G,Zhang Y

更新日期：2015-12-01 00:00:00

abstract：:In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were s...

journal_title：Molecular and cellular biochemistry

authors： Kovacs V,Gasz B,Balatonyi B,Jaromi L,Kisfali P,Borsiczky B,Jancso G,Marczin N,Szabados S,Melegh B,Nasri A,Roth E

更新日期：2014-04-01 00:00:00

abstract：:Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death...

journal_title：Molecular and cellular biochemistry

authors： Chen F,Vallyathan V,Castranova V,Shi X

更新日期：2001-06-01 00:00:00

abstract：:Increased protein kinase C (PKC) activity has been implicated in the pathogenesis of a number of diabetic complications, and high concentrations of glucose have been shown to increase PKC activity. The present study was designed to examine the role of PKC in diabetes-induced (and glucose-induced) cardiomyocyte dysfunc...

journal_title：Molecular and cellular biochemistry

authors： Davidoff AJ,Davidson MB,Carmody MW,Davis ME,Ren J

更新日期：2004-07-01 00:00:00

abstract：:Visceral leishmaniasis has been found to be associated with severe anemia and premature lysis of erythrocytes. Peroxidative damage of red cells has been noted in several hemolytic anemias. Present study shows enhanced formation of methemoglobin in hamsters infected with Leishmania donovani. Increased formation of malo...

journal_title：Molecular and cellular biochemistry

authors： Biswas T,Pal JK,Naskar K,Ghosh DK,Ghosal J

更新日期：1995-05-24 00:00:00

abstract：:p62/sequestosome-1 is a multifunctional adapter protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis, and plays an important role at the crossroad between autophagy and cancer. But, the connection between autophagy and cancer is complex and in some cases contradictory. Human colorectal...

journal_title：Molecular and cellular biochemistry

authors： Ren F,Shu G,Liu G,Liu D,Zhou J,Yuan L,Zhou J

更新日期：2014-01-01 00:00:00

abstract：:Chromium(VI) [Cr(VI)] induces chronic inflammation in hepatocytes. Inflammation has been shown to play an important role in tumorigenesis, tumor progression, and metastasis. To examine the effects of the Styrax Japonica Siebold et al. Zuccarini (SJSZ) glycoprotein on inflammation in BNL CL.2 cells, we evaluated the ac...

journal_title：Molecular and cellular biochemistry

authors： Lee J,Lim KT

更新日期：2012-08-01 00:00:00

abstract：:Signal transduction pathways control various biological processes in cells leading to distinct cellular functions. Protein-protein interactions and post-translational modifications are the physiological events that occur in signaling pathway. p38 MAPK are known to be involved in regulating wide range of cellular proce...

journal_title：Molecular and cellular biochemistry

authors： Rini J,Anbalagan M

更新日期：2017-11-01 00:00:00

abstract：:The Arrhenius plots for the active and low activity soluble forms of the ATPase purified from the membranes of Micrococcus lysodeikticus grown at 30 degrees C presented discontinuities at 30 and 33 degrees C, respectively. Their activation parameters differed, being highest for the low activity form of the enzyme. Bot...

journal_title：Molecular and cellular biochemistry

authors： Ayala J,Carreira J,Nieto M,Muñoz E

更新日期：1977-08-19 00:00:00

abstract：:Chemical and enzymatic properties of four collagenases newly isolated from anaerobic Clostridium histolyticum, aerobic Achromobacter iophagus, and from two lower eucaryotes, the fungus Entomophthora coronata and the insect Hypoderma lineatum are reviewed. The problems of their biosynthesis and precursors, namely the e...

journal_title：Molecular and cellular biochemistry

authors： Keil B

更新日期：1979-01-26 00:00:00

abstract：:Previously, we isolated and characterized the gene encoding the 3'-Nucleotidase/Nuclease (Ld3'NT/NU) from the human pathogen, Leishmania donovani. This unique cell surface enzyme has been shown to be involved in the salvage of host-derived purines, which are essential for the survival of this important protozoan paras...

journal_title：Molecular and cellular biochemistry

authors： Debrabant A,Bastien P,Dwyer DM

更新日期：2001-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of leading causes of cancer-related death, and its increasing incidence worldwide is a cause for concern. The recombinant analgesic-antitumor peptide (rAGAP), a protein consisting of small ubiquitin-related modifier linked with a hexa-histidine tag, exhibited the antitumor activit...

journal_title：Molecular and cellular biochemistry

authors： Cao Q,Lu W,Zhou T,Liu Y,Cai X,Zhu J,Cao P

更新日期：2019-05-01 00:00:00

abstract：:Hypermethylation of promoter CpG islands represents an alternative mechanism to inactivate tumor suppressor genes. This study was to detect promoter methylation status and mRNA expression levels of ARRDC3, ELP3, GATA5, and PAX6, and to explore the association between methylation and expression in invasive ductal carci...

journal_title：Molecular and cellular biochemistry

authors： Wang D,Yang PN,Chen J,Zhou XY,Liu QJ,Li HJ,Li CL

更新日期：2014-11-01 00:00:00

abstract：:Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightl...

journal_title：Molecular and cellular biochemistry

authors： Mahajan PB,Thompson EA

更新日期：1991-05-29 00:00:00