Ga-68 DOTA-NOC uptake in the pancreas: pathological and physiological patterns.

Abstract:

OBJECTIVE:Gallium-68 (Ga-68) DOTA-1-NaI3-octreotide (DOTA-NOC) positron emission tomography (PET)/computed tomography (CT) is increasingly used for neuroendocrine tumors (NETs), often found primarily in the pancreas. However, physiologic uptake of DOTA-NOC has been described in the uncinate process of the pancreas. We studied DOTA-NOC uptake in this organ. MATERIALS AND METHODS:Ninety-six patients underwent 103 DOTA-NOC scans, with pathology-proven pancreatic NET (n = 40) and nonpancreatic NET or biochemical suspicion of NET (n = 63). RESULTS:DOTA-NOC uptake was detected in 35 documented pancreatic tumor sites (SUV: 5.5-165; mean: 25.7 ± 28.8; median: 17.8). Among 63 cases without previous known pathology, uptake was suspicious for tumor in 24 sites (SUV: 4.7-35; mean 16.3 ± 8.0; median: 14.1), and in 38 sites, it was judged as physiological, generally lower relative to adjacent structures (SUV: 2.2-12.6; mean: 6.6 ± 2.2; median: 6.2). In 24 scans with suspected tumor and in 37 of 38 scans with physiological uptake, diagnostic computed tomography or magnetic resonance imaging or endoscopic ultrasonography failed to detect tumor. CONCLUSIONS:Pancreatic DOTA-NOC uptake must be interpreted with caution, and further studies are required.

journal_name

Clin Nucl Med

authors

Krausz Y,Rubinstein R,Appelbaum L,Mishani E,Orevi M,Fraenkel M,Tshori S,Glaser B,Bocher M,Salmon A,Chisin R,Gross DJ,Freedman N

doi

10.1097/RLU.0b013e3182393404

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

57-62

issue

1

eissn

0363-9762

issn

1536-0229

pii

00003072-201201000-00011

journal_volume

37

pub_type

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