A new thrombus imaging agent. Human recombinant fibrin binding domain labeled with In-111.

Abstract:

:The amino-terminal domain of fibronectin has a fibrin binding site and a site for covalent cross-linking to fibrin. This fibrin binding domain was isolated from human recombinant fibronectin and labeled with In-111; the final molecular weight was 12 kD. It was applied to a pilot study of 62 patients; 30 who were thought to have deep vein thrombosis and 32 controls. All 30 patients had either impedance plethysmography, duplex ultrasound, contrast venography, or various combinations of the three. Eight disagreements in the 30 patients suspected of having deep vein thrombosis were registered between fibrin binding domain imaging and the other examinations. Three of the patients with negative scan results had clots that were 1 week old or older, and this may be a limitation of the technique. In three other patients who had negative scan results, but positive alternative studies, there was a history of previous episodes of deep vein thrombosis and this could be a cause of false-positive results in the other modalities. There was one documented false-negative scan in a fresh clot. Normal scans were obtained in the lower extremities of the control patients, except in two who demonstrated uptake at the sites of insulin injections. The initial results of this feasibility study are encouraging and warrant further investigation.

journal_name

Clin Nucl Med

authors

Rosenthall L,Leclerc J

doi

10.1097/00003072-199505000-00004

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

398-402

issue

5

eissn

0363-9762

issn

1536-0229

journal_volume

20

pub_type

临床试验,杂志文章
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  • Efficacy and safety of 177Lu-EDTMP in bone metastatic pain palliation in breast cancer and hormone refractory prostate cancer: a phase II study.

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    更新日期:2013-02-01 00:00:00

  • Cholesterol Granuloma Masquerading as Gallbladder Carcinoma on 18F-FDG PET/CT.

    abstract::F-FDG PET/CT was performed on a 70-year-old man to stage the newly diagnosed multiple myeloma. A hypermetabolic lesion in the gallbladder fundus was revealed incidentally and suspected for gallbladder carcinoma, but was finally proven to be a cholesterol granuloma by the pathology of cholecystectomy. ...

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    abstract::Hepatobiliary studies were performed over a three-year period on 139 patients suspected of having cystic duct obstruction. Each patient was infused intravenously with sincalide, a C-terminal octapeptide of CCK, 15 minutes prior to the administration of the hepatobiliary imaging agent Tc-99m paraisopropyl iminodiacetic...

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    authors: Patterson FK,Kam JW

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  • Tumor detection with 67Ga-citrate: a literature survey (1970--1978).

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    pub_type: 杂志文章,评审

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  • 68Ga-PSMA-Ligand PET/CT Uptake in Anthracosilicosis.

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  • Chest radionuclide angiography in the evaluation of pulmonary masses.

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  • In Vivo Assessment of Tau Deposition in Alzheimer Disease and Assessing Its Relationship to Regional Brain Glucose Metabolism and Cognition.

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    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002791

    authors: Baghel V,Tripathi M,Parida G,Gupta R,Yadav S,Kumar P,Dey AB,Damle NA,Kumar R,Bal C

    更新日期:2019-11-01 00:00:00

  • Acute intramural hematoma of the aorta as a cause of positive FDG PET/CT.

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    authors: Ryan A,McCook B,Sholosh B,Pryma DA,Jablonowski E,Fuhrman C,Blodgett TM

    更新日期:2007-09-01 00:00:00

  • Asymmetric abnormality of renal perfusion with symmetric function in aortic dissection.

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  • Diagnostic value of FDG PET and salivary gland scintigraphy for parotid tumors.

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章,评审

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  • F-18 FDG PET/CT findings of primary sinonasal hemangiopericytoma: rare location in a young adult patient.

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    pub_type: 杂志文章

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    authors: Aras M,Dede F,Ones T,Atasoy BM,Inanir S,Erdil TY,Turoglu HT

    更新日期:2011-06-01 00:00:00

  • Bone Flare to Androgen Deprivation Therapy in Metastatic, Hormone-Sensitive Prostate Cancer on 68Ga-Prostate-Specific Membrane Antigen PET/CT.

    abstract::A 69-year-old man with newly diagnosed prostate cancer PSA 274 ng/mL, Gleason 4+3, T-stage 3b) underwent Ga-PSMA PET/CT for staging with follow-up scans 6 and 13 weeks after androgen deprivation therapy (ADT) initiation. Six weeks after ADT initiation, lymph node metastases observed at staging showed metabolic and rad...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

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    authors: Zacho HD,Petersen LJ

    更新日期:2018-11-01 00:00:00

  • Abnormal captopril scintigraphy in Bartter syndrome.

    abstract::A 37-year-old patient with severe hypokalemia (approximately 1.7 mEq/L) and muscular weakness had a very high serum renin level. No renin-producing tumor was found and she was diagnosed with Bartter Syndrome The parathyroid hormone level was high due to concomitant renal calcium loss. Tc-99m-DTPA captopril scintigraph...

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    pub_type: 杂志文章

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    authors: Zelmanovitz F,Fregapani JA,Zelmanovitz T,Spiro BL

    更新日期:2005-04-01 00:00:00

  • Allergic Reaction to Ginkgo Nut on FDG PET/CT.

    abstract::We report the case of a 36-year-old woman who previously underwent total thyroidectomy for papillary thyroid carcinoma. F FDG PET/CT images demonstrated multiple lymph nodes with increased FDG uptake in the neck, chest, and abdomen and diffusely increased FDG uptake in the spleen, which were highly suspicious findings...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

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    authors: Han EJ,Park HL,Kim SH

    更新日期:2016-09-01 00:00:00

  • 18F-FDG PET/CT Revealing Constrictive Pericarditis as the Only Manifestation of Malignant Mesothelioma.

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    pub_type: 杂志文章

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    authors: Edel JP,Balink H

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  • F-18 FDG positron emission tomography findings in primary pancreatic lymphoma.

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    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000135269.00531.f8

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    更新日期:2004-09-01 00:00:00

  • Cocaine-induced reflex sympathetic dystrophy.

    abstract::Reflex sympathetic dystrophy (RSD) usually follows traumatic injuries or neurologic disorders. The authors report a rare case of RSD that followed intraarterial administration of cocaine in a patient with a history of intravenous drug abuse. The cocaine was self-administered inadvertently into the femoral artery rathe...

    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/00003072-200011000-00001

    authors: Gay D,Singh A

    更新日期:2000-11-01 00:00:00

  • Integration of 68Ga-PSMA-PET/CT in Radiotherapy Planning for Prostate Cancer Patients.

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    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/RLU.0000000000002691

    authors: Onal C,Torun N,Akyol F,Guler OC,Hurmuz P,Yildirim BA,Cağlar M,Reyhan M,Ozyigit G

    更新日期:2019-09-01 00:00:00

  • Renal cell carcinoma detected on Tc-99m-labeled red blood cell imaging.

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    journal_title:Clinical nuclear medicine

    pub_type: 杂志文章

    doi:10.1097/01.rlu.0000093089.53875.3e

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    更新日期:2003-11-01 00:00:00

  • Unusual pattern of lung uptake of technetium-99m sulfur colloid seen on the liver scan of a patient with pulmonary tuberculosis.

    abstract::In evaluating alcoholic liver disease in a patient with pulmonary tuberculosis, a liver-spleen scan was performed that showed an unusual uptake of sulfur colloid in the lungs. There was diffuse uptake in the left lung and portions of the right lower lung with absent uptake in the right upper lobe and portions of the r...

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    pub_type: 杂志文章

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    authors: Stewart CA,Hung GL,Siegel ME,McHutchison JG

    更新日期:1989-04-01 00:00:00

  • Tendon abnormalities mimicking metastatic disease in patients with prostate cancer.

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    pub_type: 杂志文章

    doi:10.1097/RLU.0b013e3180a1acc3

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    更新日期:2007-08-01 00:00:00

  • Mismatch between radionuclide and contrast angiography in the assessment of the perfusion of a transplanted kidney.

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    更新日期:1991-11-01 00:00:00

  • Detection of an infected abdominal aortic aneurysm with three-phase bone scan and gallium-67 scan.

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    pub_type: 杂志文章

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    更新日期:2008-04-01 00:00:00

  • Fracture of the laryngeal cartilage. An incidental finding on bone scintigraphy.

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    pub_type: 杂志文章

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    更新日期:1992-10-01 00:00:00

  • Reverse oblique reconstruction for SPECT of the spine.

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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  • Intraosseous Medullary Fat Necrosis on 99mTc-MDP Bone Scan of Patient With Acute Pancreatitis.

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    pub_type: 杂志文章

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