Abstract:
PURPOSES:To evaluate the dosimetric effect of outpatient radioiodine therapy for thyroid cancer in members of a patient's family and their living environment, when using iodine-131 doses reaching 7.4 GBq. The following parameters were thus defined: (a) whole-body radiation doses to caregivers, (b) the production of contaminated solid waste, and (c) radiation potential and surface contamination within patients' living quarters. METHODS:In total, 100 patients were treated on an outpatient basis, taking into consideration their acceptable living conditions, interests, and willingness to comply with medical and radiation safety guidelines. Both the caregivers and the radiation dose potentiality inside patients' residences were monitored by using thermoluminescent dosimeters. Surface contamination and contaminated solid wastes were identified and measured with a Geiger-Müller detector. RESULTS:A total of 90 monitored individuals received a mean dose of 0.27 (±0.28) mSv, and the maximum dose registered was 1.6 mSv. The mean value for the potential dose within all living quarters was 0.31 (±0.34) mSv, and the mean value per monitored surface was 5.58 Bq/cm(2) for all the 1659 points measured. The overall production of contaminated solid wastes was at a low level, being about 3 times less than the exemption level indicated by the International Atomic Energy Agency. CONCLUSIONS:This study indicates that the treatment of thyroid cancer by applying radioiodine activities up to 7.4 GBq, on an outpatient basis, is a safe procedure, especially when supervised by qualified professionals. This alternative therapy should be a topic for careful discussion considering the high potential for reducing costs in healthcare and improving patient acceptance.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Willegaignon J,Sapienza M,Ono C,Watanabe T,Guimarães MI,Gutterres R,Marechal MH,Buchpiguel Cdoi
10.1097/RLU.0b013e3182184fa0subject
Has Abstractpub_date
2011-06-01 00:00:00pages
440-5issue
6eissn
0363-9762issn
1536-0229pii
00003072-201106000-00004journal_volume
36pub_type
临床试验,杂志文章abstract::The amino-terminal domain of fibronectin has a fibrin binding site and a site for covalent cross-linking to fibrin. This fibrin binding domain was isolated from human recombinant fibronectin and labeled with In-111; the final molecular weight was 12 kD. It was applied to a pilot study of 62 patients; 30 who were thoug...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00003072-199505000-00004
更新日期:1995-05-01 00:00:00
abstract::The authors describe a patient with the acquired immunodeficiency syndrome who had active pulmonary tuberculosis and was receiving anti-tuberculosis treatment. High-grade fever and a right-sided pleural effusion had recently developed. Results of a Ga-67 scan were negative for any focal infection in the chest. Fluorin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200006000-00028
更新日期:2000-06-01 00:00:00
abstract::A case of 99mTcO4 accumulation within the thorax is reported, consistent with septic emboli and thyroiditis during routine thyroid scintigraphy for subclinical hyperthyroidism. After antibiotic treatment, repeated 99mTcO4 imaging revealed complete resolution of foci of septic emboli. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000245
更新日期:2013-12-01 00:00:00
abstract::An 85-year-old woman who had an invasive ductal carcinoma of the breast and elevated alkaline phosphatases (420 U/L) was referred for Tc-99m MDP bone scintigraphy for initial evaluation of skeletal metastases. Bone symptoms were limited to chronic pain in both knees. A bone scan revealed pagetoid findings in both calc...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/01.rlu.0000247783.43949.c1
更新日期:2006-12-01 00:00:00
abstract::A 69-year-old man with biochemical recurrence after radical prostatectomy underwent 6 months of androgen deprivation therapy. Upon discontinuation of androgen deprivation therapy, serum prostate-specific antigen rose again to 0.69 ng/mL, and F-DCFPyL PET/CT was performed to identify the site of recurrence. However, on...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002428
更新日期:2019-03-01 00:00:00
abstract::Erlotinib is a reversible epidermal growth factor receptor tyrosine kinase inhibitor used to treat advanced non-small cell lung carcinoma patients who have shown progression on at least 1 prior chemotherapy regimen. Most of the patients on erlotinib show cutaneous adverse effects. We report the 18F-FDG PET/CT findings...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000586
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the utility of presynaptic dopaminergic imaging using 99mTc-TRODAT-1 SPECT/CT and 18F-FDOPA PET/CT and compare their performance in Parkinson's disease (PD), Parkinson-plus syndrome (PPS), and essential tremor (ET). PATIENTS AND METHODS:A total of 103 patients (PD = 48, PPS ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003409
更新日期:2021-02-01 00:00:00
abstract::We describe a rare case of metastatic pilomatrix carcinoma with distant metastases 10 months after diagnosis. A 37-year-old woman was diagnosed with pilomatrix carcinoma by excisional biopsy from the occipital region and referred to us for F-FDG PET/CT examinations at the time of diagnosis and 10 months after diagnosi...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002857
更新日期:2020-02-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. Often, patients present with inoperable and advanced disease. Selective internal radionuclide therapy offers prolonged survival and improved quality of life by delivering high radiation dose to the tumor with minimal complications. We report 2 inop...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002373
更新日期:2019-02-01 00:00:00
abstract::A retrospective analysis of 104 chest radionuclide angiography (CRNA) studies establishes the utility of this procedure in the evaluation of pulmonary malignancies and benign masses. Remarkable abnormalities in the perfusion of the lungs were identified in 36 (58%) of 62 cases that were not predictably normal or predi...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198409000-00005
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:To describe F-18 fluorodeoxyglucose positron emission tomography (FDG PET) profile in patients with subacute sclerosing panencephalitis (SSPE) and to investigate its possible correlation with clinical, electroencephalography (EEG) or magnetic resonance imaging/computed tomography (MRI/CT) findings. METHODS:E...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/RLU.0b013e3181e9fa5f
更新日期:2010-09-01 00:00:00
abstract::Three cases of sickle cell disease associated with functional asplenia are described. The spleen was not visualized on routine Tc-99m-sulfur colloid scan. The bone scan performed with Tc-99m-phosphate compounds revealed abnormal splenic activity in all three cases. The previous case reports and the literature on this ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198107000-00007
更新日期:1981-07-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the diagnostic capacity of F-18 fluorodeoxyglucose dual-time-point (DTP) positron emission tomography (PET)/computed tomography (CT) for intrathoracic lymph node (LN) metastases in patients with nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS:Thirty-four patients ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31819a1f3d
更新日期:2009-04-01 00:00:00
abstract::Ga somatostatin receptor PET/CT, currently the most sensitive imaging modality for well-differentiated neuroendocrine tumors, is based on the molecular imaging of somatostatin receptors (SSTRs) that are expressed in different tumor entities such as neuroendocrine neoplasms, lymphomas, meningiomas, or renal cell cancer...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000351
更新日期:2014-08-01 00:00:00
abstract::A retrospective review of two years' experience with radionuclide screening to detect lower gastrointestinal bleeding sites was conducted at New York's Montefiore Medical Center. Of 82 studies performed in 63 patients, 13 identified active bleeding sites. Only three of eight angiograms obtained in these 13 patients we...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198309000-00001
更新日期:1983-09-01 00:00:00
abstract::Immunoglobulin G4-related disease (IgG4-RD) is a systemic inflammatory condition that can manifest in atypical locations. We present the case of a middle-aged woman presenting with isolated IgG4-RD of left maxilla and nasal septum, confirmed with F-FDG PET/CT. She achieved complete metabolic response with multiple pha...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002848
更新日期:2020-02-01 00:00:00
abstract::Hyperplasia of the parathyroid glands usually is treated surgically by total parathyroidectomy, which would deprive the patient of the parathormone essential for calcium metabolism. The postoperative management of patients submitted to total parathyroidectomy consists either in oral administration of vitamin D and cal...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199212000-00010
更新日期:1992-12-01 00:00:00
abstract::Bone, brain, and gallium scintigrams are presented of a 48-year-old man with biopsy-proven cerebral amyloidosis. Brain scintigraphy revealed a well-circumscribed accumulation of Tc-99m pertechnetate in the amyloidoma. Bone scintigraphy using Tc-99m methylenediphosphonate likewise exhibited increased activity in the sa...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198311000-00003
更新日期:1983-11-01 00:00:00
abstract::A 19-year-old male military recruit presented with 3 weeks of persistent left hip and groin pain after abnormally twisting his hip during a hike. Initial radiographs were interpreted as negative. He subsequently underwent a bone scan which revealed linear left sacral uptake along or paralleling the sacroiliac joint. D...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001666
更新日期:2017-06-01 00:00:00
abstract:PURPOSE:Renal biopsy is crucial for management of lupus nephritis. However, it is invasive and can cause bleeding and infection. In our previous study, we developed a semiquantitative method for gallium renal imaging and demonstrated a good correlation between the left kidney-to-spine ratio (K/S ratio) and the results ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001108
更新日期:2016-06-01 00:00:00
abstract::A patient receiving nephrotoxic chemotherapy for metastatic cervical cancer was examined for acute renal failure. A Tc-99m MAG3 scan showed symmetric function, bilateral increasing parenchymal activity, and no tracer excretion in either collecting system. The differential diagnosis included cisplatin-induced nephrotox...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200202000-00007
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate whether computed tomography based-attenuation correction (CT-AC) provides any advantage over non-attenuation-corrected (NAC) images for qualitative and quantitative analysis of single photon emission tomography (SPECT) myocardial perfusion imaging (MPI). METHODS:W...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31823ea16b
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate the incremental value of cocktail F-FDG/F-NaF PET/CT over F-FDG PET/CT alone for detection of skeletal metastases in breast cancer patients. METHODS:Seventy patients with locally advanced/recurrent breast cancer were prospectively included. All patients underwent whole-bod...
journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
doi:10.1097/RLU.0000000000001615
更新日期:2017-05-01 00:00:00
abstract::Pulmonary perfusion scintigraphy with Tc-99m MAA was performed on 182 patients, on whom either pneumonectomy or lobectomy was performed, because of primary nonsmall-cell lung carcinoma. Among them, 76 underwent pneumonectomy, and 106 underwent lobectomy. The mean value of the perfusion fraction (PF) of the affected lu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199419120-00012
更新日期:1994-12-01 00:00:00
abstract::In this article, the authors described a 31-year-old woman with differentiated thyroid cancer is presented who had radioiodine uptake in the distribution of the tracheobronchial tree in association with symptoms of an acute respiratory tract infection. As expected, the uptake was transient and disappeared on the follo...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199705000-00006
更新日期:1997-05-01 00:00:00
abstract::The uptake of fluorine-18 fluorodeoxyglucose (F-18 FDG) by a malignant tumor depends on the blood glucose level. The authors present a striking case that illustrates the importance of blood glucose measurement in F-18 FDG positron emission tomographic (PET) imaging in a patient with a solitary pulmonary nodule. With t...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200111000-00002
更新日期:2001-11-01 00:00:00
abstract::Malignant melanoma is a rare malignant tumor arising within the melanocytes of the skin. The authors report a case of primary and metastatic malignant melanoma revealed with Tc-99m MIBI in one patient. Tc-99m MIBI images showed uptake in possible malignant melanoma skin lesions of the left calf and great toe of a 73-y...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-200205000-00008
更新日期:2002-05-01 00:00:00
abstract::Focal radionuclide accumulation of Tc-99m sulfur colloid (SC) and tc-99m macroaggregated albumin (MAA) in the liver has been reported in both inferior and superior vena caval obstruction. We studied a patient with uniform radionuclide accumulation of Tc-99m MAA in the liver during lung scintigraphy. In this patient, b...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198308000-00009
更新日期:1983-08-01 00:00:00
abstract::A 10-year-old girl with a history of complicated cystic fibrosis was hospitalized for pulmonary exacerbation with allergic bronchopulmonary aspergillosis and severe right upper lobe bronchiectasis diagnosed with chest radiograph and CT. She was started on itraconazole during the hospitalization in attempt to decrease ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002264
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:We aim to retrospectively evaluate the impact of hormone therapy (HT) on FDG avidity of metastatic lesions in patients with breast cancer (BC) undergoing PET/CT. PATIENTS AND METHODS:Three hundred eight patients with BC were scanned with PET/CT at 2 Italian institutions (mean time from diagnosis 4 yrs, rang...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318287353e
更新日期:2014-02-01 00:00:00