S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs.

abstract：:Echocardiography, a non-invasive and cost-effective method for monitoring cardiac function, is commonly used for evaluation and pre-clinical diagnostics of pulmonary hypertension (PH). Previous echocardiographic studies in experimental models of PH are fragmentary in terms of the evaluation of right ventricle (RV) fun...

journal_title：Pulmonary circulation

authors： Zhu Z,Godana D,Li A,Rodriguez B,Gu C,Tang H,Minshall RD,Huang W,Chen J

更新日期：2019-04-01 00:00:00

abstract：:Current evidence suggests that exercise training is beneficial in pulmonary arterial hypertension (PAH). Unfortunately, the standard supervised, hospital-based programs limit patient accessibility to this important intervention. Our proof-of-concept study aimed to provide insight into the usefulness of a prescribed wa...

journal_title：Pulmonary circulation

authors： Brown MB,Kempf A,Collins CM,Long GM,Owens M,Gupta S,Hellman Y,Wong V,Farber M,Lahm T

更新日期：2018-01-01 00:00:00

abstract：:Despite the discovery more than 15 years ago that patients with hereditary pulmonary arterial hypertension (HPAH) inherit BMP type 2 receptor ( BMPR2) mutations, it is still unclear how these mutations cause disease. In part, this is attributable to the rarity of HPAH and difficulty obtaining tissue samples from patie...

journal_title：Pulmonary circulation

authors： Frump A,Prewitt A,de Caestecker MP

更新日期：2018-04-01 00:00:00

abstract：:[This corrects the article DOI: 10.1086/688060.]. ...

journal_title：Pulmonary circulation

authors：

更新日期：2016-12-01 00:00:00

abstract：:Quantifying metabolic derangements in pulmonary hypertension (PH) by plasma metabolomics could identify biomarkers useful for diagnosis and treatment. The objective of this paper is to test the hypotheses that circulating metabolites are differentially expressed in PH patients compared with controls and among differen...

journal_title：Pulmonary circulation

authors： Luo N,Craig D,Ilkayeva O,Muehlbauer M,Kraus WE,Newgard CB,Shah SH,Rajagopal S

更新日期：2017-02-01 00:00:00

abstract：:We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes...

journal_title：Pulmonary circulation

authors： Yum SK,Kim MS,Kwun Y,Moon CJ,Youn YA,Sung IK

更新日期：2018-04-01 00:00:00

abstract：:African Americans (AA) have a higher incidence of pulmonary hypertension (PH) risk factors. Few studies have examined the racial differences in the prevalence and etiology of PH and direct comparison of invasive hemodynamics between AAs and Caucasians has rarely been reported. In this study, we examined whether racial...

journal_title：Pulmonary circulation

authors： Yang BQ,Assad TR,O'Leary JM,Xu M,Halliday SJ,D'Amico RW,Farber-Eger EH,Wells QS,Hemnes AR,Brittain EL

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is characterized by obstruction of pre-capillary pulmonary arteries, which leads to sustained elevation of pulmonary arterial pressure. Identifying those at risk through early interventions, such as genetic testing, may mitigate disease course. Current practice guidelines recommen...

journal_title：Pulmonary circulation

authors： Jacher JE,Martin LJ,Chung WK,Loyd JE,Nichols WC

更新日期：2017-04-01 00:00:00

abstract：:Insulin resistance is highly prevalent in pulmonary arterial hypertension (PAH) patients. However, the long-term impact of diabetes mellitus (DM) on survival in PAH is unclear. Insulin resistance and DM are associated with left ventricular steatosis and dysfunction, but whether the right ventricle (RV) might be affect...

journal_title：Pulmonary circulation

authors： Benson L,Brittain EL,Pugh ME,Austin ED,Fox K,Wheeler L,Robbins IM,Hemnes AR

更新日期：2014-06-01 00:00:00

abstract：:Infection, thrombosis, and catheter dislodgment are well-recognized potential complications of chronic intravenous prostanoid therapy for pulmonary arterial hypertension. As long-term outcomes of pulmonary hypertension patients improve, novel adverse events are likely to arise. We describe the sudden development of un...

journal_title：Pulmonary circulation

authors： LeVarge BL,Law AC,Murphy B

更新日期：2018-01-01 00:00:00

abstract：:Increased exposure to ambient particulate matter (PM) is associated with elevated morbidity and mortality in patients with cardiopulmonary diseases and cancer. We and others have shown that PM induces lung microvascular barrier dysfunction which potentially enhances the systemic toxicity of PM. However, the mechanisms...

journal_title：Pulmonary circulation

authors： Wang T,Shimizu Y,Wu X,Kelly GT,Xu X,Wang L,Qian Z,Chen Y,Garcia JGN

更新日期：2017-07-01 00:00:00

abstract：:The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute...

journal_title：Pulmonary circulation

authors： Karki P,Birukova AA

更新日期：2018-04-01 00:00:00

abstract：:This manuscript on endpoints incorporates the broad experience of members of Pulmonary Vascular Research Institute's Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertens...

journal_title：Pulmonary circulation

authors： Sitbon O,Nikkho S,Benza R,Cq Deng C,W Farber H,Gomberg-Maitland M,Hassoun P,Meier C,Pepke-Zaba J,Prasad K,Seeger W,Corris PA

更新日期：2020-11-18 00:00:00

abstract：:Hypereosinophilic syndrome is a myeloproliferative disorder characterized by persistent eosinophilia with involvement of multiple organs. The occurrence of severe pulmonary hypertension (PH) in the setting of hypereosinophilic syndrome is very uncommon. A 43-year-old man with documented idiopathic hypereosinophlic syn...

journal_title：Pulmonary circulation

authors： Zhang L,Peng X,Adhikari BK,Li B,Liu Q,Mikeladze J,Zhang W

更新日期：2019-01-01 00:00:00

abstract：:N-terminal pro B-type natriuretic peptide (NT-proBNP) is a product of cleavage of the cardiac prohormone pro B-type natriuretic peptide into its active form. It has proven to be a useful biomarker in left heart failure. However, studies examining the utility of serial measurements of NT-proBNP in pulmonary arterial hy...

journal_title：Pulmonary circulation

authors： Soon E,Doughty NJ,Treacy CM,Ross RM,Toshner M,Upton PD,Sheares K,Morrell NW,Pepke-Zaba J

更新日期：2011-04-01 00:00:00

abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) require lifelong anticoagulation therapy. However, the bleeding risk and recurrence of venous thromboembolism (VTE) in CTEPH patients who are administered warfarin have not been adequately evaluated. The purpose of this study was to evaluate the risk ...

journal_title：Pulmonary circulation

authors： Jujo-Sanada T,Tanabe N,Sakao S,Sugiura T,Sekine A,Nishimura R,Suda R,Naito A,Miwa H,Yamamoto K,Sasaki A,Matsumura A,Ema R,Kasai H,Kato F,Tatsumi K

更新日期：2017-07-01 00:00:00

abstract：:Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described. Tracheobronchial compression from pulmonary arterial dilatation is rare in adults, and there are ...

journal_title：Pulmonary circulation

authors： Jaijee SK,Ariff B,Howard L,O'Regan DP,Gin-Sing W,Davies R,Gibbs JS

更新日期：2015-12-01 00:00:00

abstract：:The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role ...

journal_title：Pulmonary circulation

authors： Duarte JD,Kansal M,Desai AA,Riden K,Arwood MJ,Yacob AA,Stamos TD,Cavallari LH,Zamanian RT,Shah SJ,Machado RF

更新日期：2018-04-01 00:00:00

abstract：:The aim of this study was to investigate whether a dual endothelin receptor antagonist bosentan modulates the kinetics of bone marrow-derived stem cells in inhibiting the development of pulmonary hypertension. Bone marrow chimeric mice, transplanted with enhanced green fluorescent protein (eGFP)-positive bone marrow m...

journal_title：Pulmonary circulation

authors： Kato T,Mitani Y,Masuya M,Maruyama J,Sawada H,Ohashi H,Ikeyama Y,Otsuki S,Yodoya N,Shinohara T,Miyata E,Zhang E,Katayama N,Shimpo H,Maruyama K,Komada Y,Hirayama M

更新日期：2020-05-14 00:00:00

abstract：:Pathological alterations of inspiratory capacity (IC) have been observed in pulmonary hypertension. However, the clinical significance of IC in operable chronic thromboembolic pulmonary hypertension (CTEPH) without other pulmonary diseases remains unknown. CTEPH patients scheduled for pulmonary endarterectomy were pro...

journal_title：Pulmonary circulation

authors： Richter MJ,Gall H,Wittkämper G,Seeger W,Mayer E,Ghofrani HA,Guth S,Reichenberger F

更新日期：2017-04-01 00:00:00

abstract：:Pulmonary endarterectomy (PEA) is the standard therapy for chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) is an alternative therapy for such patients. Here we report the case of a 60-year-old woman who presented with severe CTEPH resulting in low cardiac output and liver fai...

journal_title：Pulmonary circulation

authors： Tsuji A,Ogo T,Demachi J,Ono Y,Sanda Y,Morita Y,Fukuda T,Nakanishi N

更新日期：2014-03-01 00:00:00

abstract：:Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the poten...

journal_title：Pulmonary circulation

authors： Gaskill C,Marriott S,Pratap S,Menon S,Hedges LK,Fessel JP,Kropski JA,Ames D,Wheeler L,Loyd JE,Hemnes AR,Roop DR,Klemm DJ,Austin ED,Majka SM

更新日期：2016-12-01 00:00:00

abstract：:Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and i...

journal_title：Pulmonary circulation

authors： Nickel NP,de Jesus Perez VA,Zamanian RT,Fessel JP,Cogan JD,Hamid R,West JD,de Caestecker MP,Yang H,Austin ED

更新日期：2019-04-01 00:00:00

abstract：:Patients with pulmonary hypertension are more sedentary than the general population, but attitudes and experiences that may influence their exercise behaviour remain poorly understood. This study identified patterns of behaviour, attitudes towards exercise, barriers and enablers of exercise for people living with pulm...

journal_title：Pulmonary circulation

authors： Chia KSW,Brown K,Kotlyar E,Wong PKK,Faux SG,Shiner CT

更新日期：2020-11-16 00:00:00

abstract：:Little is known about the impact of metabolic syndrome (MS) on right ventricular (RV) structure and function. We hypothesized that mice fed a Western diet (WD) would develop RV lipid accumulation and impaired RV function, which would be ameliorated with metformin. Male C57/Bl6 mice were fed a WD or standard rodent die...

journal_title：Pulmonary circulation

authors： Brittain EL,Talati M,Fortune N,Agrawal V,Meoli DF,West J,Hemnes AR

更新日期：2019-01-01 00:00:00

abstract：:Riociguat is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Some patients have difficulty swallowing tablets; therefore, 2 randomized, nonblinded, crossover studies compared the relative bioavailability of riociguat oral suspensions and immediate-releas...

journal_title：Pulmonary circulation

authors： Saleh S,Frey R,Becker C,Unger S,Wensing G,Mück W

更新日期：2016-03-01 00:00:00

abstract：:Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this "estrogen paradoxȍ of enhanced female survival despite increased female susceptibility remains a mystery, recent pro...

journal_title：Pulmonary circulation

authors： Austin ED,Lahm T,West J,Tofovic SP,Johansen AK,Maclean MR,Alzoubi A,Oka M

更新日期：2013-04-01 00:00:00

abstract：:Adherence to therapy for pulmonary arterial hypertension is essential to optimize patient outcomes, but data on real-world adherence to different pulmonary arterial hypertension drug classes are limited. This retrospective database analysis evaluated relationships between adherence, hospitalization, and healthcare cos...

journal_title：Pulmonary circulation

authors： Frantz RP,Hill JW,Lickert CA,Wade RL,Cole MR,Tsang Y,Drake W 3rd

更新日期：2020-03-18 00:00:00

abstract：:Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness (CMS). We hypothesized that differences in neonatal oxygenation were involved, with arterial O2 saturation (SaO2) being highest in...

journal_title：Pulmonary circulation

authors： Niermeyer S,Andrade-M MP,Vargas E,Moore LG

更新日期：2015-03-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of unresolved organised pulmonary emboli/thrombi obstructing the major pulmonary arteries. The aim of this study was to estimate the incidence and risk factors of CTEPH in a cohort with first venous thromboembolism (VTE). This was a population-bas...

journal_title：Pulmonary circulation

authors： Martinez C,Wallenhorst C,Teal S,Cohen AT,Peacock AJ

更新日期：2018-07-01 00:00:00