Rescue balloon pulmonary angioplasty in a rapidly deteriorating chronic thromboembolic pulmonary hypertension patient with liver failure and refractory infection.

abstract：:The biological mechanisms behind the development of pulmonary hypertension in the setting of left heart failure (HF-PH), including combined pre- and post-capillary pulmonary hypertension (Cpc-PH), remains unclear. This study aimed to use candidate polymorphisms in nitric oxide synthase (NOS) genes to explore the role ...

journal_title：Pulmonary circulation

authors： Duarte JD,Kansal M,Desai AA,Riden K,Arwood MJ,Yacob AA,Stamos TD,Cavallari LH,Zamanian RT,Shah SJ,Machado RF

更新日期：2018-04-01 00:00:00

abstract：:Acute respiratory distress syndrome in patients with Coronavirus disease 19 is associated with an unusually high incidence of pulmonary embolism and microthrombotic disease, with evidence for reduced fibrinolysis. We describe seven patients requiring invasive ventilation for COVID-19-associated acute respiratory distr...

journal_title：Pulmonary circulation

authors： Price LC,Garfield B,Bleakley C,Keeling AGM,Mcfadyen C,McCabe C,Ridge CA,Wort SJ,Price S,Arachchillage DJ

更新日期：2020-12-15 00:00:00

abstract：:Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described. Tracheobronchial compression from pulmonary arterial dilatation is rare in adults, and there are ...

journal_title：Pulmonary circulation

authors： Jaijee SK,Ariff B,Howard L,O'Regan DP,Gin-Sing W,Davies R,Gibbs JS

更新日期：2015-12-01 00:00:00

abstract：:Oral treprostinil (TRE) is a prostacylin that is approved for the treatment of patients with pulmonary arterial hypertension (PAH). Dosing is approved for two or three times daily (t.i.d.); however, adverse effects, including gastrointestinal-related symptoms, may limit the ability to reach optimal doses. We report ou...

journal_title：Pulmonary circulation

authors： Coons JC,Bunner C,Ishizawar DC,Risbano MG,Rivera-Lebron B,Mathier MA,Chan SY,Simon MA

更新日期：2018-01-01 00:00:00

abstract：:Abstract Changes in voltage-gated K(+) (Kv) channel function contribute to the pathogenesis of pulmonary hypertension. Yet the mechanisms underlying Kv channel impairments in the pulmonary circulation remain unclear. We tested the hypothesis that reactive oxygen species (ROSs) contribute to the Kv channel dysfunction ...

journal_title：Pulmonary circulation

authors： Fike CD,Aschner JL,Kaplowitz MR,Zhang Y,Madden JA

更新日期：2013-09-01 00:00:00

abstract：:A loss of K+ efflux in pulmonary arterial smooth muscle cells (PASMCs) contributes to abnormal vasoconstriction and PASMC proliferation during pulmonary hypertension (PH). Activation of high-conductance Ca2+-activated (BK) channels represents a therapeutic strategy to restore K+ efflux to the affected PASMCs. However,...

journal_title：Pulmonary circulation

authors： Detweiler ND,Song L,McClenahan SJ,Versluis RJ,Kharade SV,Kurten RC,Rhee SW,Rusch NJ

更新日期：2016-12-01 00:00:00

abstract：:Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right ventricular function is the most important predictor of morbidity and mortality in patients suffering from pulmonary hypertension, but currently there are no approved treatments directly supporting the failing right ventricle...

journal_title：Pulmonary circulation

authors： Hansen MS,Andersen A,Nielsen-Kudsk JE

更新日期：2018-07-01 00:00:00

abstract：:Two oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A retrospective administrative claims study was conducted using the Optum...

journal_title：Pulmonary circulation

authors： McConnell JW,Tsang Y,Pruett J,Iii WD

更新日期：2020-11-10 00:00:00

abstract：:In a subgroup of patients with systemic sclerosis (SSc), vasospasm affecting the pulmonary circulation may contribute to worsening respiratory symptoms, including dyspnea. Noninvasive assessment of pulmonary blood flow (PBF), utilizing inert-gas rebreathing (IGR) and dual-energy computed-tomography pulmonary angiograp...

journal_title：Pulmonary circulation

authors： Keir GJ,Nair A,Giannarou S,Yang GZ,Oldershaw P,Wort SJ,MacDonald P,Hansell DM,Wells AU

更新日期：2015-09-01 00:00:00

abstract：:Optimal pulmonary hypertension (PH) management relies on a timely, accurate diagnosis and follow-up in specialized clinics by multidisciplinary teams that have clearly defined responsibilities and protocols. Internationally agreed criteria for expert center staff are lacking, particularly with respect to nurses, who o...

journal_title：Pulmonary circulation

authors： Doyle-Cox C,Nicholson G,Stewart T,Gin-Sing W

更新日期：2019-04-01 00:00:00

abstract：:African Americans (AA) have a higher incidence of pulmonary hypertension (PH) risk factors. Few studies have examined the racial differences in the prevalence and etiology of PH and direct comparison of invasive hemodynamics between AAs and Caucasians has rarely been reported. In this study, we examined whether racial...

journal_title：Pulmonary circulation

authors： Yang BQ,Assad TR,O'Leary JM,Xu M,Halliday SJ,D'Amico RW,Farber-Eger EH,Wells QS,Hemnes AR,Brittain EL

更新日期：2018-04-01 00:00:00

abstract：:Current knowledge gaps pertaining to diagnosis and management of neonatal chronic pulmonary hypertension (cPH) may result in significant variability in clinical practice. The objective of the study is to understand cPH management practices in neonatal intensive care units affiliated with the Canadian Neonatal Network ...

journal_title：Pulmonary circulation

authors： Baczynski M,Bell EF,Finan E,McNamara PJ,Jain A

更新日期：2020-07-16 00:00:00

abstract：:Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported. Anagrelide is an oral imidazoquinazoline agent that is prescribed for reducing elevated platelet counts in patients with m...

journal_title：Pulmonary circulation

authors： Sumimoto K,Taniguchi Y,Matsuoka Y,Onishi H,Emoto N,Hirata KI

更新日期：2019-12-27 00:00:00

abstract：:Endothelial nitric oxide synthase (eNOS) plays a major role in maintaining pulmonary vascular homeostasis. Tetrahydrobiopterin (BH4), an essential cofactor that stabilizes the dimerization of eNOS and balances nitric oxide (NO) and superoxide production, may have therapeutic potential in pulmonary hypertension. In the...

journal_title：Pulmonary circulation

authors： Francis BN,Hale A,Channon KM,Wilkins MR,Zhao L

更新日期：2014-09-01 00:00:00

abstract：:Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM)...

journal_title：Pulmonary circulation

authors： Chyou AC,Klein BEK,Klein R,Barr RG,Cotch MF,Praestgaard A,Wong TY,Lima J,Bluemke DA,Kawut S

更新日期：2018-12-03 00:00:00

abstract：:Pulmonary capillary hemangiomatosis (PCH) is a rare form of pulmonary arterial hypertension (PAH) characterized by pulmonary capillary proliferation and pseudoinvasion of collagenous septal structures. PCH is often accompanied by veno-occlusive changes and pulmonary hypertensive arterial remodeling. The clinical and p...

journal_title：Pulmonary circulation

authors： DuBrock HM,Kradin RL,Rodriguez-Lopez JM,Channick RN

更新日期：2015-09-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects. Nanomedicine uses nanoparticles to improve drug delivery and/or reduce side effects. We hypothesize that thi...

journal_title：Pulmonary circulation

authors： Mohamed NA,Davies RP,Lickiss PD,Ahmetaj-Shala B,Reed DM,Gashaw HH,Saleem H,Freeman GR,George PM,Wort SJ,Morales-Cano D,Barreira B,Tetley TD,Chester AH,Yacoub MH,Kirkby NS,Moreno L,Mitchell JA

更新日期：2017-07-01 00:00:00

abstract：:While it is well established that the haemodynamic cause of hypoxic pulmonary hypertension is increased pulmonary vascular resistance, the molecular pathogenesis of the increased resistance remains incompletely understood. Macrophage migration inhibitory factor is a pleiotropic cytokine with endogenous tautomerase enz...

journal_title：Pulmonary circulation

authors： Li L,Xu M,Rowan SC,Howell K,Russell-Hallinan A,Donnelly SC,McLoughlin P,Baugh JA

更新日期：2020-10-26 00:00:00

abstract：:Insulin resistance is highly prevalent in pulmonary arterial hypertension (PAH) patients. However, the long-term impact of diabetes mellitus (DM) on survival in PAH is unclear. Insulin resistance and DM are associated with left ventricular steatosis and dysfunction, but whether the right ventricle (RV) might be affect...

journal_title：Pulmonary circulation

authors： Benson L,Brittain EL,Pugh ME,Austin ED,Fox K,Wheeler L,Robbins IM,Hemnes AR

更新日期：2014-06-01 00:00:00

abstract：:This manuscript on endpoints incorporates the broad experience of members of Pulmonary Vascular Research Institute's Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertens...

journal_title：Pulmonary circulation

authors： Sitbon O,Nikkho S,Benza R,Cq Deng C,W Farber H,Gomberg-Maitland M,Hassoun P,Meier C,Pepke-Zaba J,Prasad K,Seeger W,Corris PA

更新日期：2020-11-18 00:00:00

abstract：:PH occurs alone or in association with many disorders. Many patients with transthoracic echocardiography (TTE) findings suggesting PH never receive additional evaluation. Patient characteristics and echocardiographic data associated with increased recognition of PH have not been fully evaluated. We evaluated TTE repor...

journal_title：Pulmonary circulation

authors： Kingrey JF,Panos RJ,Ying J,Meganathan K,Vandivier R,Elwing JM

更新日期：2013-04-01 00:00:00

abstract：:Current evidence suggests that exercise training is beneficial in pulmonary arterial hypertension (PAH). Unfortunately, the standard supervised, hospital-based programs limit patient accessibility to this important intervention. Our proof-of-concept study aimed to provide insight into the usefulness of a prescribed wa...

journal_title：Pulmonary circulation

authors： Brown MB,Kempf A,Collins CM,Long GM,Owens M,Gupta S,Hellman Y,Wong V,Farber M,Lahm T

更新日期：2018-01-01 00:00:00

abstract：:We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes...

journal_title：Pulmonary circulation

authors： Yum SK,Kim MS,Kwun Y,Moon CJ,Youn YA,Sung IK

更新日期：2018-04-01 00:00:00

abstract：:Pulmonary hypertension (PH) comprises a group of pathophysiological syndromes characterized by elevated pulmonary artery pressure and pulmonary vascular resistance, which lead to right ventricular overload, and even right heart failure. PH has a poor prognosis and severely leads to a decline in quality of life. Histor...

journal_title：Pulmonary circulation

authors： Zhang X,Xu D

更新日期：2020-07-07 00:00:00

abstract：:Transforming growth factor-β (TGF-β) inhibition is an investigational therapy for pulmonary arterial hypertension with promising results in experimental studies. The present work compared this approach with endothelin-receptor blockade and evaluated the effects of combined administration. Pulmonary arterial hypertensi...

journal_title：Pulmonary circulation

authors： Megalou AJ,Glava C,Vilaeti AD,Oikonomidis DL,Baltogiannis GG,Papalois A,Vlahos AP,Kolettis TM

更新日期：2012-10-01 00:00:00

abstract：:Pulmonary hypertension currently has minimal guidelines for outpatient disease management. Congestive heart failure studies, however, have shown effectiveness of disease management plans in reducing all-cause mortality and all-cause and congestive heart failure-related hospital readmissions. Heart failure exacerbation...

journal_title：Pulmonary circulation

authors： Dolan J,Mandras S,Mehta JP,Navas V,Tarver J,Chakinala M,Rahaghi F

更新日期：2020-12-07 00:00:00

abstract：:Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension. Here, we show that chronic hypoxia fails to promote CREB depletion in pulmonary artery smooth muscle...

journal_title：Pulmonary circulation

authors： Garat CV,Majka SM,Sullivan TM,Crossno JT Jr,Reusch JEB,Klemm DJ

更新日期：2020-04-14 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a rapidly progressive and fatal disease for which there is an ever-expanding body of genetic and related pathophysiological information on disease pathogenesis. The most common single culprit gene known is BMPR2, and animal models of the disease in several forms exist. There is...

journal_title：Pulmonary circulation

authors： Fessel JP,Loyd JE,Austin ED

更新日期：2011-07-01 00:00:00

abstract：:Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the poten...

journal_title：Pulmonary circulation

authors： Gaskill C,Marriott S,Pratap S,Menon S,Hedges LK,Fessel JP,Kropski JA,Ames D,Wheeler L,Loyd JE,Hemnes AR,Roop DR,Klemm DJ,Austin ED,Majka SM

更新日期：2016-12-01 00:00:00

abstract：:Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to mutations in the bone morphogenetic protein receptor type 2, pulmonary vascular dysfunction and i...

journal_title：Pulmonary circulation

authors： Nickel NP,de Jesus Perez VA,Zamanian RT,Fessel JP,Cogan JD,Hamid R,West JD,de Caestecker MP,Yang H,Austin ED

更新日期：2019-04-01 00:00:00