A non-selective endothelin receptor antagonist bosentan modulates kinetics of bone marrow-derived cells in ameliorating pulmonary hypertension in mice.

abstract：:Pulmonary arterial hypertension (PAH) is a major complication of sickle cell disease (SCD). Low levels of apolipoprotein A1 (Apo-A1) have been implicated in the development of PAH in SCD. We speculate that lower levels of Apo-A1 are related to dysregulation of the ubiquitin-proteasome pathway (UPP). Of 36 recruited pa...

journal_title：Pulmonary circulation

authors： Anjum F,Lazar J,Soh J,Albitar M,Gowda S,Hussain MM,Wadgaonkar R

更新日期：2013-12-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension (CTEPH) is a complication of unresolved organised pulmonary emboli/thrombi obstructing the major pulmonary arteries. The aim of this study was to estimate the incidence and risk factors of CTEPH in a cohort with first venous thromboembolism (VTE). This was a population-bas...

journal_title：Pulmonary circulation

authors： Martinez C,Wallenhorst C,Teal S,Cohen AT,Peacock AJ

更新日期：2018-07-01 00:00:00

abstract：:Two oral medications targeting the prostacyclin pathway are available to treat pulmonary arterial hypertension in the United States: oral treprostinil and selexipag. We compared real-world hospitalization in patients receiving these medications. A retrospective administrative claims study was conducted using the Optum...

journal_title：Pulmonary circulation

authors： McConnell JW,Tsang Y,Pruett J,Iii WD

更新日期：2020-11-10 00:00:00

abstract：:Levels of the cAMP-responsive transcription factor, CREB, are reduced in medial smooth muscle cells in remodeled pulmonary arteries from hypertensive calves and rats with chronic hypoxia-induced pulmonary hypertension. Here, we show that chronic hypoxia fails to promote CREB depletion in pulmonary artery smooth muscle...

journal_title：Pulmonary circulation

authors： Garat CV,Majka SM,Sullivan TM,Crossno JT Jr,Reusch JEB,Klemm DJ

更新日期：2020-04-14 00:00:00

abstract：:Insulin resistance is highly prevalent in pulmonary arterial hypertension (PAH) patients. However, the long-term impact of diabetes mellitus (DM) on survival in PAH is unclear. Insulin resistance and DM are associated with left ventricular steatosis and dysfunction, but whether the right ventricle (RV) might be affect...

journal_title：Pulmonary circulation

authors： Benson L,Brittain EL,Pugh ME,Austin ED,Fox K,Wheeler L,Robbins IM,Hemnes AR

更新日期：2014-06-01 00:00:00

abstract：:Many dyspneic patients who undergo computerized tomographic pulmonary angiography (CTPA) for presumed acute pulmonary embolism (PE) have no identified cause for their dyspnea yet have persistent symptoms, leading to more CTPA scanning. Right ventricular (RV) dysfunction or overload can signal treatable causes of dyspn...

journal_title：Pulmonary circulation

authors： Kline JA,Russell FM,Lahm T,Mastouri RA

更新日期：2015-03-01 00:00:00

abstract：:Chronic lung disease (CLD), including pulmonary fibrosis (PF) and chronic obstructive pulmonary disease (COPD), is the fourth leading cause of mortality worldwide. Both are debilitating pathologies that impede overall tissue function. A common co-morbidity in CLD is vasculopathy, characterized by deregulated angiogene...

journal_title：Pulmonary circulation

authors： Kropski JA,Richmond BW,Gaskill CF,Foronjy RF,Majka SM

更新日期：2018-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a rapidly progressive and fatal disease for which there is an ever-expanding body of genetic and related pathophysiological information on disease pathogenesis. The most common single culprit gene known is BMPR2, and animal models of the disease in several forms exist. There is...

journal_title：Pulmonary circulation

authors： Fessel JP,Loyd JE,Austin ED

更新日期：2011-07-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) patients have distinct disease courses and responses to treatment, but current diagnostic and treatment schemes provide limited insight. We aimed to see if cluster analysis could distinguish clinical phenotypes in PAH. An unbiased cluster analysis was performed on 17 baseline clin...

journal_title：Pulmonary circulation

authors： Parikh KS,Rao Y,Ahmad T,Shen K,Felker GM,Rajagopal S

更新日期：2017-04-01 00:00:00

abstract：:Right ventricular (RV) dysfunction in acute respiratory distress syndrome (ARDS) contributes to increased mortality. Our aim is to identify reproducible transthoracic echocardiography (TTE) parameters of RV dysfunction that can be used to predict outcomes in ARDS. We performed a retrospective single-center cohort pilo...

journal_title：Pulmonary circulation

authors： Shah TG,Wadia SK,Kovach J,Fogg L,Tandon R

更新日期：2016-06-01 00:00:00

abstract：:We hypothesized that vibrations created by the pulmonary circulation would create sound like the vocal cords during speech and that subjects with pulmonary artery hypertension (PAH) might have a unique sound signature. We recorded heart sounds at the cardiac apex and the second left intercostal space (2LICS), using a ...

journal_title：Pulmonary circulation

authors： Elgendi M,Bobhate P,Jain S,Guo L,Kumar S,Rutledge J,Coe Y,Zemp R,Schuurmans D,Adatia I

更新日期：2015-12-01 00:00:00

abstract：:Pulmonary endarterectomy (PEA) is the standard therapy for chronic thromboembolic pulmonary hypertension (CTEPH). Balloon pulmonary angioplasty (BPA) is an alternative therapy for such patients. Here we report the case of a 60-year-old woman who presented with severe CTEPH resulting in low cardiac output and liver fai...

journal_title：Pulmonary circulation

authors： Tsuji A,Ogo T,Demachi J,Ono Y,Sanda Y,Morita Y,Fukuda T,Nakanishi N

更新日期：2014-03-01 00:00:00

abstract：:Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the poten...

journal_title：Pulmonary circulation

authors： Gaskill C,Marriott S,Pratap S,Menon S,Hedges LK,Fessel JP,Kropski JA,Ames D,Wheeler L,Loyd JE,Hemnes AR,Roop DR,Klemm DJ,Austin ED,Majka SM

更新日期：2016-12-01 00:00:00

abstract：:Patients with chronic thromboembolic pulmonary hypertension (CTEPH) require lifelong anticoagulation therapy. However, the bleeding risk and recurrence of venous thromboembolism (VTE) in CTEPH patients who are administered warfarin have not been adequately evaluated. The purpose of this study was to evaluate the risk ...

journal_title：Pulmonary circulation

authors： Jujo-Sanada T,Tanabe N,Sakao S,Sugiura T,Sekine A,Nishimura R,Suda R,Naito A,Miwa H,Yamamoto K,Sasaki A,Matsumura A,Ema R,Kasai H,Kato F,Tatsumi K

更新日期：2017-07-01 00:00:00

abstract：:Andeans and Tibetans have less altitude reduction in birth weight than do shorter-resident groups, but only Tibetans are protected from pulmonary hypertension and chronic mountain sickness (CMS). We hypothesized that differences in neonatal oxygenation were involved, with arterial O2 saturation (SaO2) being highest in...

journal_title：Pulmonary circulation

authors： Niermeyer S,Andrade-M MP,Vargas E,Moore LG

更新日期：2015-03-01 00:00:00

abstract：:Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as acute or subacute radiation-induced lung injury (RILI). Although the molecular etiology of RILI is controversial and likely multifactorial, a potentially important cellular target is the lung endothelial cytoskeleton tha...

journal_title：Pulmonary circulation

authors： Wang T,Mathew B,Wu X,Shimizu Y,Rizzo AN,Dudek SM,Weichselbaum RR,Jacobson JR,Hecker L,Garcia JG

更新日期：2016-06-01 00:00:00

abstract：:Right ventricular (RV) function is a strong independent predictor of outcome in a number of distinct cardiopulmonary diseases. The RV has a remarkable ability to sustain damage and recover function which may be related to unique anatomic, physiologic, and genetic factors that differentiate it from the left ventricle. ...

journal_title：Pulmonary circulation

authors： Brittain EL,Hemnes AR,Keebler M,Lawson M,Byrd BF 3rd,Disalvo T

更新日期：2012-07-01 00:00:00

abstract：:A loss of K+ efflux in pulmonary arterial smooth muscle cells (PASMCs) contributes to abnormal vasoconstriction and PASMC proliferation during pulmonary hypertension (PH). Activation of high-conductance Ca2+-activated (BK) channels represents a therapeutic strategy to restore K+ efflux to the affected PASMCs. However,...

journal_title：Pulmonary circulation

authors： Detweiler ND,Song L,McClenahan SJ,Versluis RJ,Kharade SV,Kurten RC,Rhee SW,Rusch NJ

更新日期：2016-12-01 00:00:00

abstract：:This manuscript on endpoints incorporates the broad experience of members of Pulmonary Vascular Research Institute's Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertens...

journal_title：Pulmonary circulation

authors： Sitbon O,Nikkho S,Benza R,Cq Deng C,W Farber H,Gomberg-Maitland M,Hassoun P,Meier C,Pepke-Zaba J,Prasad K,Seeger W,Corris PA

更新日期：2020-11-18 00:00:00

abstract：:With the advancement of computed tomography pulmonary angiography, differentiating between acute and chronic thrombus in pulmonary embolism has become more feasible. However, whether pulmonary embolism with chronic thrombus contributes to a higher mortality than pulmonary embolism with acute thrombus remains undetermi...

journal_title：Pulmonary circulation

authors： Chang HY,Chang WT,Chen PW,Lin CC,Hsu CH

更新日期：2020-05-01 00:00:00

abstract：:Right-ventricular function is a good indicator of pulmonary arterial hypertension (PAH) prognosis; however, how the right ventricle (RV) adapts to the pressure overload is not well understood. Here, we aimed at characterizing the time course of RV early remodeling and discriminate the contribution of ventricular geome...

journal_title：Pulmonary circulation

authors： Vélez-Rendón D,Zhang X,Gerringer J,Valdez-Jasso D

更新日期：2018-10-01 00:00:00

abstract：:The maintenance of endothelial barrier integrity is absolutely essential to prevent the vascular leak associated with pneumonia, pulmonary edema resulting from inhalation of toxins, acute elevation to high altitude, traumatic and septic lung injury, acute lung injury (ALI), and its life-threatening complication, acute...

journal_title：Pulmonary circulation

authors： Karki P,Birukova AA

更新日期：2018-04-01 00:00:00

abstract：:Despite recent advances, the prognosis of pulmonary hypertension (PH) remains poor. While the initial insult in PH implicates the pulmonary vasculature, the functional state, exercise capacity, and survival of such patients are closely linked to right ventricular (RV) function. In the current study, we sought to inves...

journal_title：Pulmonary circulation

authors： Singh I,Rahaghi FN,Naeije R,Oliveira RKF,Vanderpool RR,Waxman AB,Systrom DM

更新日期：2019-07-01 00:00:00

abstract：:Retinal vessel diameters have been associated with left ventricular morphology and function but their relationship with the right ventricle (RV) has not been studied. We hypothesized that wider retinal venules and narrower retinal arterioles are associated with RV morphology and function. RV end-diastolic mass (RVEDM)...

journal_title：Pulmonary circulation

authors： Chyou AC,Klein BEK,Klein R,Barr RG,Cotch MF,Praestgaard A,Wong TY,Lima J,Bluemke DA,Kawut S

更新日期：2018-12-03 00:00:00

abstract：:In 301 treatment-naïve patients with pulmonary arterial hypertension stratified by the European Society of Cardiology/European Respiratory Society risk score, further stratification of intermediate-risk patients based on six-minute walk distance and the tricuspid annular plane systolic excursion/systolic pulmonary art...

journal_title：Pulmonary circulation

authors： Yogeswaran A,Richter MJ,Sommer N,Ghofrani HA,Seeger W,Tello K,Gall H

更新日期：2020-10-07 00:00:00

abstract：:Endothelial nitric oxide synthase (eNOS) plays a major role in maintaining pulmonary vascular homeostasis. Tetrahydrobiopterin (BH4), an essential cofactor that stabilizes the dimerization of eNOS and balances nitric oxide (NO) and superoxide production, may have therapeutic potential in pulmonary hypertension. In the...

journal_title：Pulmonary circulation

authors： Francis BN,Hale A,Channon KM,Wilkins MR,Zhao L

更新日期：2014-09-01 00:00:00

abstract：: ...

journal_title：Pulmonary circulation

authors： Liu BY,Wu WC,Zeng QX,Liu ZH,Tian Y,Niu LL,Cheng XL,Luo Q,Zhao Z,An CH,Huang L,Wang H,He J,Xiong CM

更新日期：2019-07-03 00:00:00

abstract：:We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes...

journal_title：Pulmonary circulation

authors： Yum SK,Kim MS,Kwun Y,Moon CJ,Youn YA,Sung IK

更新日期：2018-04-01 00:00:00

abstract：:Increased exposure to ambient particulate matter (PM) is associated with elevated morbidity and mortality in patients with cardiopulmonary diseases and cancer. We and others have shown that PM induces lung microvascular barrier dysfunction which potentially enhances the systemic toxicity of PM. However, the mechanisms...

journal_title：Pulmonary circulation

authors： Wang T,Shimizu Y,Wu X,Kelly GT,Xu X,Wang L,Qian Z,Chen Y,Garcia JGN

更新日期：2017-07-01 00:00:00

abstract：:Our aim is to assess the safety and potential efficacy of a novel treatment paradigm in pulmonary arterial hypertension (PAH), immunomodulation by blocking interleukin-6 (IL6) signaling with the IL6 receptor antagonist, tocilizumab. Inflammation and autoimmunity are established as important in PAH pathophysiology. One...

journal_title：Pulmonary circulation

authors： Hernández-Sánchez J,Harlow L,Church C,Gaine S,Knightbridge E,Bunclark K,Gor D,Bedding A,Morrell N,Corris P,Toshner M

更新日期：2018-01-01 00:00:00