Abstract:
:In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the ischemic myocardium, it results in further reperfusion injury and extension of the infarction. The main hypothesis for the mechanism of reperfusion injury is the generation of reactive oxygen species (ROS) to such a degree that endogenous antioxidant mechanisms are overcome and tissue injury results. There is growing evidence that ROS-induced injury may continue for weeks to months as a result of activation of apoptosis. In the longer term, this may result in ventricular remodeling and cardiac failure. Although a number of antioxidants have produced beneficial effects in animal models of AMI, none have proved efficacious in subsequent clinical trials. Drugs that are more specific for the source of ROS generation and that are better able to target the sources of oxidant stress may have greater potential for the prevention of reperfusion injury.
journal_name
Expert Rev Clin Pharmacoljournal_title
Expert review of clinical pharmacologyauthors
Qin C,Yap S,Woodman OLdoi
10.1586/ecp.09.41subject
Has Abstractpub_date
2009-11-01 00:00:00pages
673-95issue
6eissn
1751-2433issn
1751-2441journal_volume
2pub_type
杂志文章abstract:INTRODUCTION:The need to develop new drugs for the control of pathogenic microorganisms has redoubled efforts to prospect for antimicrobial peptides (AMPs) from natural sources and to characterize its structure and function. These molecules present a broad spectrum of action against different microorganisms and frequen...
journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
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