Seek and destroy: improving PK/PD profiles of anticancer agents with nanoparticles.

abstract：:Hydrogen sulfide (H(2)S) is now considered a member of a group of signaling molecules termed 'gasotransmitters'. H(2)S has been shown to be generated in the endocrine and reproductive organs and elicits various actions. H(2)S modulates insulin secretion in pancreatic islets. Adipose tissues have the ability to produce...

journal_title：Expert review of clinical pharmacology

authors： Zhu XY,Gu H,Ni X

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Pharmacological inhibition of immune checkpoint receptors or their ligands represents a transformative breakthrough in the management of multiple cancers. However, immune checkpoint inhibitors have yet to be FDA-approved for the management of metastatic prostate cancer (PCa), the commonest non-cutaneous ma...

journal_title：Expert review of clinical pharmacology

authors： Isaacsson Velho P,Antonarakis ES

更新日期：2018-05-01 00:00:00

abstract：:Contraceptive management in women with epilepsy is critical owing to the potential maternal and fetal risks if contraception or seizure management fails. This article briefly describes the pharmacokinetic interactions between antiepileptic drugs (AEDs) and hormonal contraceptives and the rational strategies that may o...

journal_title：Expert review of clinical pharmacology

authors： Reddy DS

更新日期：2010-03-01 00:00:00

abstract：:Alzheimer's disease is the most common cause of dementia and is becoming a global health concern. Despite a well-established understanding of the molecular mechanism involved in its pathogenesis, and millions of dollars of investment in drug discovery and clinical trials, no single molecule has yet been approved for i...

journal_title：Expert review of clinical pharmacology

authors： Léger GC,Massoud F

更新日期：2013-07-01 00:00:00

abstract：INTRODUCTION:The incidence of kidney dysfunction increases with age and is highly prevalent among patients with hypertension. Since many therapeutic compounds are primarily eliminated through the kidneys, impaired renal function can have negative consequences on drug disposition, efficacy and safety. Therefore, regulat...

journal_title：Expert review of clinical pharmacology

authors： Paglialunga S,Offman E,Ichhpurani N,Marbury TC,Morimoto BH

更新日期：2017-03-01 00:00:00

abstract：:Introduction: Patients with early HER2-positive breast cancer (BC) benefit from HER2-targeted systemic therapy. The endorsed standard adjuvant treatment for patients with early HER2-positive breast cancer is chemotherapy plus trastuzumab administered for 1 year. Areas covered: Several trials have investigated modifica...

journal_title：Expert review of clinical pharmacology

authors： Esposito A,Viale G,Criscitiello C,Curigliano G

更新日期：2019-01-01 00:00:00

abstract：:In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the ischemic myocardium, it results in further reperfusion injury and extension of the infarction. The main hypothesis for the mechanism of reperfus...

journal_title：Expert review of clinical pharmacology

authors： Qin C,Yap S,Woodman OL

更新日期：2009-11-01 00:00:00

abstract：INTRODUCTION:More than half of the patients with inflammatory bowel disease (IBD) experience at least one extra-intestinal manifestation (EIM). The most common EIM in patients with IBD is spondyloarthritis (SpA). Microscopic intestinal inflammation is documented in almost 50% of the patients with SpA. Areas covered: We...

journal_title：Expert review of clinical pharmacology

authors： Pouillon L,Bossuyt P,Vanderstukken J,Moulin D,Netter P,Danese S,Jouzeau JY,Loeuille D,Peyrin-Biroulet L

更新日期：2017-12-01 00:00:00

abstract：:Aripiprazole monohydrate (AM) and aripiprazole lauroxil (AL) are two different long-acting injectable formulations of aripiprazole. AM 400 mg administered once monthly demonstrated efficacy in an acute, double-blind, placebo-controlled, randomized clinical trial, as well as in a double-blind, placebo-controlled, rando...

journal_title：Expert review of clinical pharmacology

authors： Citrome L

更新日期：2016-01-01 00:00:00

abstract：:Respiratory distress syndrome (RDS) is the leading cause of neonatal morbidity and mortality in premature infants. It is caused by surfactant deficiency and lung immaturity. Lucinactant is a synthetic surfactant containing sinapultide, a bioengineered peptide mimic of surfactant-associated protein B. A meta-analysis o...

journal_title：Expert review of clinical pharmacology

authors： Jordan BK,Donn SM

更新日期：2013-03-01 00:00:00

abstract：:RNAi is a powerful gene silencing process that holds great promise in cancer therapy by the use of siRNA. The aim of this review is to give an outline on different approaches to deliver siRNA and to describe the advantages and disadvantages of these systems. The prospects for siRNA are to be substantially better than ...

journal_title：Expert review of clinical pharmacology

authors： Ali HM,Urbinati G,Raouane M,Massaad-Massade L

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Gemtuzumab ozogamicin (GO) is an antibody-drug conjugate consisting of a monoclonal antibody targeting CD33 linked to a cytotoxic derivative of calicheamicin. Despite the known clinical efficacy in relapsed/refractory acute myeloid leukemia (AML), GO was withdrawn from the market in 2010 due to increased e...

journal_title：Expert review of clinical pharmacology

authors： Baron J,Wang ES

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Betalactams are the most widely used drugs against infections and the primary cause of antibiotic hypersensitivity reactions. Reaction patterns for different betalactams have been changing in accordance with consumption trends, and vary among countries. As a consequence, in vivo and in vitro tests have had...

journal_title：Expert review of clinical pharmacology

authors： Fernandez TD,Mayorga C,Salas M,Barrionuevo E,Posadas T,Ariza A,Laguna JJ,Moreno E,Torres MJ,Doña I,Montañez MI

更新日期：2017-06-01 00:00:00

abstract：:Osteoarthritis is a progressive disease that affects millions of people worldwide, but for which there are no curative options and indeed a limited number of medical treatment options. The American College of Rheumatology recommendations suggest administering either a traditional NSAID or a COX-2-selective inhibitor f...

journal_title：Expert review of clinical pharmacology

authors： Sebba A

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Gaucher disease (GD) is an autosomal recessive disorder resulting from the deficiency of the lysosomal enzyme glucocerebrosidase (b-glucosidase), associated with varying degrees of visceral, bone and central nervous system pathology, leading to wide phenotypic diversity. Response to therapy and clinical ou...

journal_title：Expert review of clinical pharmacology

authors： Gupta P,Pastores G

更新日期：2018-12-01 00:00:00

abstract：:Despite advances in our understanding of the molecular and genetic basis of pancreatic cancer, it continues to be a therapeutic challenge. Gemcitabine approved by FDA in 1997, offers modest improvement of tumor-related symptoms and marginal advantage of survival. Many chemotherapeutic agents have been compared against...

journal_title：Expert review of clinical pharmacology

authors： Saif MW

更新日期：2014-07-01 00:00:00

abstract：:After the introduction of anti-tumor necrosis factor (anti-TNF) agents, the clinical outcome of patients with Inflammatory Bowel Disease (IBD) has improved significantly. However, use of anti-TNF therapy is complicated by loss of response. In order to maintain remission, adequate serum levels are required. Hence, ther...

journal_title：Expert review of clinical pharmacology

authors： Strik AS,Bots SJ,D'Haens G,Löwenberg M

更新日期：2016-01-01 00:00:00

abstract：:Zanamivir is currently not recommended by the WHO for the first-line treatment of human influenza A (H5N1) infections. Zanamivir pharmacokinetics and antiviral efficacy were reviewed to assess the basis for this recommendation. Following inhalation of 10 mg zanamivir in healthy humans, the drug is widely distributed t...

journal_title：Expert review of clinical pharmacology

authors： Reece PA

更新日期：2010-01-01 00:00:00

abstract：:Novel pharmaceutical advances in postoperative pain management include both non-opioid adjuvants as well as opioid analgesics. Optimizing postoperative analgesics includes improving onset of action, matching duration of analgesia to the setting of use, and minimizing adverse events. To improve on the current standard ...

journal_title：Expert review of clinical pharmacology

authors： Palmer P

更新日期：2015-01-01 00:00:00

abstract：:Introduction: Dementia is the 7th leading cause of death that imposes a significant financial and service burden on the global population. Presently, only symptomatic care exists for cognitive loss, such as Alzheimer's disease.Areas covered: Given the advancing age of the global population, it becomes imperative to de...

journal_title：Expert review of clinical pharmacology

authors： Maiese K

更新日期：2020-01-01 00:00:00

abstract：:Introduction: The placenta is a temporary and unique organ that allows for the physical connection between a mother and fetus; this organ regulates the transport of gases and nutrients mediating the elimination of waste products contained in the fetal circulation. The placenta performs metabolic and excretion function...

journal_title：Expert review of clinical pharmacology

authors： Blanco-Castañeda R,Galaviz-Hernández C,Souto PCS,Lima VV,Giachini FR,Escudero C,Damiano AE,Barragán-Zúñiga LJ,Martínez-Aguilar G,Sosa-Macías M

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:Diabetes mellitus is associated with increased cardiovascular disease (CVD) risk. Areas covered: Main goal of hypolipidemic treatment in diabetic patients is low-density lipoprotein cholesterol (LDL-C) lowering with the use of statins. Addition of ezetimibe is useful in diabetic patients who cannot achieve...

journal_title：Expert review of clinical pharmacology

authors： Filippatos TD,Florentin M,Georgoula M,Elisaf MS

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:In the modern antimicrobial era, the rapid spread of resistance to antibiotics and introduction of new and mutating viruses is a global concern. Combating antimicrobial resistant microbes (AMR) requires coordinated international efforts that incorporate new conventional antibiotic development as well as de...

journal_title：Expert review of clinical pharmacology

authors： Enioutina EY,Teng L,Fateeva TV,Brown JCS,Job KM,Bortnikova VV,Krepkova LV,Gubarev MI,Sherwin CMT

更新日期：2017-11-01 00:00:00

abstract：:Reducing the burden of falciparum malaria in pregnancy is an urgent international public health priority but one that involves considerable challenges. The rapidly declining effectiveness of agents known to be safe in pregnancy, and the limited efficacy, safety and pharmacokinetic data available for many other antimal...

journal_title：Expert review of clinical pharmacology

authors： Vallely A,McCarthy J,Changalucha J,Vallely L,Chandramohan D

更新日期：2008-01-01 00:00:00

abstract：:Preeclampsia is a pregnancy-specific multisystem disorder, complicating 2 - 8% of pregnancies, and represents a leading cause of maternal and perinatal morbidity and mortality. Recent investigations have elucidated the understanding of its underlying pathogenic mechanisms. However, despite these advances, therapeutic ...

journal_title：Expert review of clinical pharmacology

authors： Ornaghi S,Paidas MJ

更新日期：2014-09-01 00:00:00

abstract：:Introduction: Statins remain among the most frequently prescribed drugs and constitute a cornerstone in the prevention of cardiovascular disease. However, muscle symptoms are often reported from patients on statins. Muscle symptoms are frequently reported as adverse events associated with statin therapy.Areas covered:...

journal_title：Expert review of clinical pharmacology

authors： Pergolizzi JV Jr,Coluzzi F,Colucci RD,Olsson H,LeQuang JA,Al-Saadi J,Magnusson P

更新日期：2020-03-01 00:00:00

abstract：:The oxazolidinones are a new class of antibiotics whose mechanism of action is the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. Linezolid is the first member of this class of antibiotics to be approved by the US FDA and other regulatory bodies for the treatment of infections cause...

journal_title：Expert review of clinical pharmacology

authors： Tan TQ,Yogev R

更新日期：2008-07-01 00:00:00

abstract：:G-quadruplexes are non-Watson-Crick four-stranded nucleic acid structures. Recent evidence points toward their existence in vivo and their implication in various biological processes. Over the past two decades, small molecules have been developed to specifically and selectively target these structures in order to diss...

journal_title：Expert review of clinical pharmacology

authors： Müller S,Rodriguez R

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:In pediatric pharmacotherapy, many drugs are still used off-label, and their efficacy and safety is not well characterized. Different efficacy and safety profiles in children of varying ages may be anticipated, due to developmental changes occurring across pediatric life. AREAS COVERED:Beside pharmacokine...

journal_title：Expert review of clinical pharmacology

authors： Brussee JM,Calvier EA,Krekels EH,Välitalo PA,Tibboel D,Allegaert K,Knibbe CA

更新日期：2016-09-01 00:00:00

abstract：:Introduction: Primary endpoints and inclusion/exclusion criteria of biologics and small oral molecules for psoriasis treatment have been evolving due to a better understanding of the pathogenesis and potential risks.Areas covered: We analyzed the designs of key phase 3 pivotal trials of all biologics and small oral mo...

journal_title：Expert review of clinical pharmacology

authors： Hsu SH,Tsai TF

更新日期：2020-03-01 00:00:00