Abstract:
:Sodium-glucose co-transporter-2 inhibitors (SGLT-2I) are recently approved class of anti-hyperglycaemic agents for the treatment of type 2 diabetes mellitus (T2DM). SGLT-2I inhibits renal glucose reabsorption, thereby ensuing urinary glucose excretion in a dose-dependent manner. This caloric loss and osmotic diuresis, secondary to increased urinary glucose excretion, has a unique potential to counter insulin induced weight gain and fluid retention, with little potential of hypoglycemic exacerbation. Also, as these agents act independently of insulin secretion or action, they are effective even in long-standing diabetes with depleted β-cell reserve. Improvement in insulin sensitivity, as observed with SGLT-2I can also facilitate insulin action. Furthermore, significant reduction in total daily insulin dosage and reduction of body weight as observed during combination therapy renders SGLT-2I, a near-ideal partner to insulin. This review aims to evaluate the safety and efficacy of currently used SGLT-2I as an add-on to insulin therapy in the treatment of T2DM.
journal_name
Expert Rev Clin Pharmacoljournal_title
Expert review of clinical pharmacologyauthors
Singh AK,Singh Rdoi
10.1586/17512433.2016.1131121subject
Has Abstractpub_date
2016-01-01 00:00:00pages
409-18issue
3eissn
1751-2433issn
1751-2441journal_volume
9pub_type
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
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pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,评审
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journal_title:Expert review of clinical pharmacology
pub_type: 杂志文章,meta分析,评审
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