A meta-analysis of apremilast on psoriatic arthritis long-term assessment of clinical efficacy (PALACE).

abstract：:Aripiprazole monohydrate (AM) and aripiprazole lauroxil (AL) are two different long-acting injectable formulations of aripiprazole. AM 400 mg administered once monthly demonstrated efficacy in an acute, double-blind, placebo-controlled, randomized clinical trial, as well as in a double-blind, placebo-controlled, rando...

journal_title：Expert review of clinical pharmacology

authors： Citrome L

更新日期：2016-01-01 00:00:00

abstract：:Preeclampsia is a pregnancy-specific multisystem disorder, complicating 2 - 8% of pregnancies, and represents a leading cause of maternal and perinatal morbidity and mortality. Recent investigations have elucidated the understanding of its underlying pathogenic mechanisms. However, despite these advances, therapeutic ...

journal_title：Expert review of clinical pharmacology

authors： Ornaghi S,Paidas MJ

更新日期：2014-09-01 00:00:00

abstract：:Contraceptive management in women with epilepsy is critical owing to the potential maternal and fetal risks if contraception or seizure management fails. This article briefly describes the pharmacokinetic interactions between antiepileptic drugs (AEDs) and hormonal contraceptives and the rational strategies that may o...

journal_title：Expert review of clinical pharmacology

authors： Reddy DS

更新日期：2010-03-01 00:00:00

abstract：INTRODUCTION:Checkpoint inhibitor immunotherapy has revolutionized the treatment of many advanced stage cancers. Preexisting immunity is necessary for a response to these agents, which are most effective in inflamed tumors since they principally act by reinforcing preexisting antitumor T-cell responses. An important go...

journal_title：Expert review of clinical pharmacology

authors： Festino L,Vanella V,Trojaniello C,Ascierto PA

更新日期：2018-10-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is now considered a member of a group of signaling molecules termed 'gasotransmitters'. H(2)S has been shown to be generated in the endocrine and reproductive organs and elicits various actions. H(2)S modulates insulin secretion in pancreatic islets. Adipose tissues have the ability to produce...

journal_title：Expert review of clinical pharmacology

authors： Zhu XY,Gu H,Ni X

更新日期：2011-01-01 00:00:00

abstract：:The unprecedented levels of political, technical and financial support for improved malaria control, and particularly for changes in the malaria treatment policy, have heralded a renewed appreciation of the role of pharmacovigilance, its relationship with other areas of public health and the development of novel appro...

journal_title：Expert review of clinical pharmacology

authors： Mehta U,Allen E,Barnes KI

更新日期：2010-07-01 00:00:00

abstract：:The oxazolidinones are a new class of antibiotics whose mechanism of action is the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. Linezolid is the first member of this class of antibiotics to be approved by the US FDA and other regulatory bodies for the treatment of infections cause...

journal_title：Expert review of clinical pharmacology

authors： Tan TQ,Yogev R

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Patients with moderate to severe COVID-19 infection require specific drugs to prevent the morbidity and mortality. Hydroxychloroquine (HCQ) has shown some promise in the management of COVID 19. Minocycline, because of its anticytokine and other useful properties can be an ideal candidate for combining with...

journal_title：Expert review of clinical pharmacology

authors： Gautam SS,Gautam CS,Garg VK,Singh H

更新日期：2020-11-01 00:00:00

abstract：:Pharmacogenomics is a rapidly developing sector of human genetics research with arguably the highest potential for immediate benefit. There is a considerable body of evidence demonstrating that variability in drug-treatment response can be explained in part by genetic variation. Subsequently, much research has ensued ...

journal_title：Expert review of clinical pharmacology

authors： Turner SD,Crawford DC,Ritchie MD

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:It was assumed for decades that the human placenta serves as a barrier, protecting the fetus from exposure to xenobiotics circulating in the mother. The thalidomide disaster completely reversed this concept. The study of the human placenta is therefore critical to understanding the mechanisms by which xeno...

journal_title：Expert review of clinical pharmacology

authors： Koren G,Ornoy A

更新日期：2018-04-01 00:00:00

abstract：:The thermo transient receptor potential (TRP) ion channels, a recently discovered family of ion channels activated by temperature, are expressed in primary sensory nerve terminals, where they provide information regarding thermal changes in the environment. Six thermo-TRPs have been characterized to date: TRPV1-4, whi...

journal_title：Expert review of clinical pharmacology

authors： Vay L,Gu C,McNaughton PA

更新日期：2010-09-01 00:00:00

abstract：:Research on the specific effects of sex and gender on pharmacokinetics and pharmacodynamics, as well as safety profile tolerability and drug efficacy, of medications remain meager because female animals and women have only recently been included in the pharmacological domain. To date, the influence of sex and gender o...

journal_title：Expert review of clinical pharmacology

authors： Franconi F,Campesi I

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:The immune system can restrain or promote cancer development and growth. Antibodies targeting immune checkpoints have revolutionized cancer treatment. Among the best responses have been in non-small cell lung cancer (NSCLC) which is largely caused by chronic exposure to carcinogens; associated with high ne...

journal_title：Expert review of clinical pharmacology

authors： Santini FC,Rudin CM

更新日期：2017-09-01 00:00:00

abstract：:Introduction: Statins remain among the most frequently prescribed drugs and constitute a cornerstone in the prevention of cardiovascular disease. However, muscle symptoms are often reported from patients on statins. Muscle symptoms are frequently reported as adverse events associated with statin therapy.Areas covered:...

journal_title：Expert review of clinical pharmacology

authors： Pergolizzi JV Jr,Coluzzi F,Colucci RD,Olsson H,LeQuang JA,Al-Saadi J,Magnusson P

更新日期：2020-03-01 00:00:00

abstract：INTRODUCTION:Therapeutic efficiency of NSAID is handicapped by ongoing discussion of cardiovascular (CV) safety. Areas covered: We update meta-analyses on NSAIDs in patients with and without cardiovascular (CV) diseases and analyse the association between NSAIDs and cardiovascular events in patients with inflammation. ...

journal_title：Expert review of clinical pharmacology

authors： Zingler G,Hermann B,Fischer T,Herdegen T

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Gaucher disease (GD) is an autosomal recessive disorder resulting from the deficiency of the lysosomal enzyme glucocerebrosidase (b-glucosidase), associated with varying degrees of visceral, bone and central nervous system pathology, leading to wide phenotypic diversity. Response to therapy and clinical ou...

journal_title：Expert review of clinical pharmacology

authors： Gupta P,Pastores G

更新日期：2018-12-01 00:00:00

abstract：:Acetaminophen (APAP)/paracetamol is one of the most commonly used over-the-counter drugs taken worldwide for treatment of pain and fever. Although considered as safe when taken in recommended doses not higher than 4 g/day, APAP overdose is currently the most important cause of acute liver failure (ALF). ALF may requir...

journal_title：Expert review of clinical pharmacology

authors： Tiegs G,Karimi K,Brune K,Arck P

更新日期：2014-09-01 00:00:00

abstract：:Introduction: In September of 2018, the United States Federal Drug Administration (FDA) approved cemiplimab-rwlc (Libtayo) for advanced cutaneous squamous cell carcinoma (CSCC). Cemiplimab is an intravenous human monoclonal antibody directed against programmed cell death-1 receptor (PD-1). Cemiplimab blocks T-cell ina...

journal_title：Expert review of clinical pharmacology

authors： Ahmed SR,Petersen E,Patel R,Migden MR

更新日期：2019-10-01 00:00:00

abstract：:Introduction: The clinical use of tacrolimus is characterized by many side effects which include neurotoxicity. In contrast, tacrolimus has also shown to have neuroregenerative properties. On a molecular level, the mechanisms of action could provide us more insight into understanding the neurobiological effects. The a...

journal_title：Expert review of clinical pharmacology

authors： Saffari TM,Bedar M,Zuidam JM,Shin AY,Baan CC,Hesselink DA,Hundepool CA

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:The need to develop new drugs for the control of pathogenic microorganisms has redoubled efforts to prospect for antimicrobial peptides (AMPs) from natural sources and to characterize its structure and function. These molecules present a broad spectrum of action against different microorganisms and frequen...

journal_title：Expert review of clinical pharmacology

authors： Sampaio de Oliveira KB,Leite ML,Rodrigues GR,Duque HM,da Costa RA,Cunha VA,de Loiola Costa LS,da Cunha NB,Franco OL,Dias SC

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Betalactams are the most widely used drugs against infections and the primary cause of antibiotic hypersensitivity reactions. Reaction patterns for different betalactams have been changing in accordance with consumption trends, and vary among countries. As a consequence, in vivo and in vitro tests have had...

journal_title：Expert review of clinical pharmacology

authors： Fernandez TD,Mayorga C,Salas M,Barrionuevo E,Posadas T,Ariza A,Laguna JJ,Moreno E,Torres MJ,Doña I,Montañez MI

更新日期：2017-06-01 00:00:00

abstract：:In the management of chronic obstructive pulmonary disease (COPD), there is an unmet medical need for effective bronchodilator treatments that not only have a fast onset of action, but also a long duration of action and are delivered using a simple, easy-to-use device. Long-acting muscarinic antagonists such as glycop...

journal_title：Expert review of clinical pharmacology

authors： Molimard M,D'Andrea P

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To estimate the prevalence of polypharmacy (≥5 drugs) among adults and to analyze related factors. METHODS:Cross-sectional study with 1,159 interviewees distributed across 104 cities and 253 primary healthcare services delivered through the Brazilian Unified Health System. Polypharmacy-related factors were ...

journal_title：Expert review of clinical pharmacology

authors： Moreira T,Alvares-Teodoro J,Barbosa MM,Do Nascimento RCRM,Guerra Júnior AA,Acurcio FA

更新日期：2020-12-01 00:00:00

abstract：:Introduction: Combined antiretroviral therapy (cART) has transformed an inexorably fatal disease into a chronic pathology, shifting the focus of research from the control of viral replication to the possibility of HIV cure. Areas covered: The present review assesses the principal pharmacological strategies that have b...

journal_title：Expert review of clinical pharmacology

authors： Giacomelli A,de Rose S,Rusconi S

更新日期：2019-01-01 00:00:00

abstract：:Pregnancy represents a major challenge in the management of patients with systemic lupus erythematosus, with substantial risks to both mother and baby. Over the past 40 years there have been major improvements in outcomes. This partly relates to the discovery of the antiphospholipid syndrome, which has transformed man...

journal_title：Expert review of clinical pharmacology

authors： Karim MY,D'Cruz DP

更新日期：2010-11-01 00:00:00

abstract：:Inflammation plays a critical role in host defense, maintaining cellular and tissue integrity following chemical, physical and biological insults. Inflammation presents in a variety of acute and chronic disease states and can contribute to disease resolution or progression depending upon the type, magnitude and durati...

journal_title：Expert review of clinical pharmacology

authors： Cressman AM,Petrovic V,Piquette-Miller M

更新日期：2012-01-01 00:00:00

abstract：:After the introduction of anti-tumor necrosis factor (anti-TNF) agents, the clinical outcome of patients with Inflammatory Bowel Disease (IBD) has improved significantly. However, use of anti-TNF therapy is complicated by loss of response. In order to maintain remission, adequate serum levels are required. Hence, ther...

journal_title：Expert review of clinical pharmacology

authors： Strik AS,Bots SJ,D'Haens G,Löwenberg M

更新日期：2016-01-01 00:00:00

abstract：:Data from clinical trials, retrospective and cross-sectional studies have quantified the metabolic changes associated with long-term use of antiepileptic drugs (AEDs). AEDs can be associated with weight gain or weight loss, although most are weight neutral. Weight gain is not only a cosmetic problem but also a risk fo...

journal_title：Expert review of clinical pharmacology

authors： Hamed SA

更新日期：2015-01-01 00:00:00

abstract：:Introduction: Dementia is the 7th leading cause of death that imposes a significant financial and service burden on the global population. Presently, only symptomatic care exists for cognitive loss, such as Alzheimer's disease.Areas covered: Given the advancing age of the global population, it becomes imperative to de...

journal_title：Expert review of clinical pharmacology

authors： Maiese K

更新日期：2020-01-01 00:00:00

abstract：:The QT interval from the ECG cannot be measured precisely. The relationship of the QT interval to the RR interval within individuals across time and different RR values, and across individuals eludes complete understanding. Intrinsic beat-to-beat variability in QT interval corrected for heart rate (QTc interval) is no...

journal_title：Expert review of clinical pharmacology

authors： Beasley CM Jr,Dmitrienko A,Mitchell MI

更新日期：2008-11-01 00:00:00