Abstract:
:Nucleosomes, which contain DNA and proteins, are the basic unit of eukaryotic chromatins. Polymers such as DNA and proteins are dynamic, and their conformational changes can lead to functional changes. Periodic dinucleotide patterns exist in nucleosomal DNA chains and play an important role in the nucleosome structure. In this paper, we use normal mode analysis to detect significant structural deformations of nucleosomal DNA and investigate the relationship between periodic dinucleotides and DNA motions. We have found that periodic dinucleotides are usually located at the peaks or valleys of DNA and protein motions, revealing that they dominate the nucleosome dynamics. Also, a specific dinucleotide pattern CA/TG appears most frequently.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Wang DD,Yan Hdoi
10.1088/1478-3975/8/6/066004subject
Has Abstractpub_date
2011-12-01 00:00:00pages
066004issue
6eissn
1478-3967issn
1478-3975pii
S1478-3975(11)87313-9journal_volume
8pub_type
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