Abstract:
:We present a simple two-state model to understand the size-dependent endocytosis of nanoparticles. Using this model, we elucidate the relevant energy terms required to understand the size-dependent uptake mechanism and verify it by correctly predicting the behavior at large and small particle sizes. In the absence of interactions between the nanoparticles, we observe an asymmetric distribution of sizes with maximum uptake at intermediate sizes and a minimum size cut-off below which there can be no endocytosis. Including the effect of interactions in our model has remarkable effects on the uptake characteristics. Attractive interactions shift the minimum size cut-off and increase the optimal uptake while repulsive interactions make the distribution more symmetric lowering the optimal uptake.
journal_name
Phys Bioljournal_title
Physical biologyauthors
Chaudhuri A,Battaglia G,Golestanian Rdoi
10.1088/1478-3975/8/4/046002subject
Has Abstractpub_date
2011-08-01 00:00:00pages
046002issue
4eissn
1478-3967issn
1478-3975pii
S1478-3975(11)81551-7journal_volume
8pub_type
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