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Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity.

Abstract：

:We describe a bioinformatic tool, Tumor Aberration Prediction Suite (TAPS), for the identification of allele-specific copy numbers in tumor samples using data from Affymetrix SNP arrays. It includes detailed visualization of genomic segment characteristics and iterative pattern recognition for copy number identification, and does not require patient-matched normal samples. TAPS can be used to identify chromosomal aberrations with high sensitivity even when the proportion of tumor cells is as low as 30%. Analysis of cancer samples indicates that TAPS is well suited to investigate samples with aneuploidy and tumor heterogeneity, which is commonly found in many types of solid tumors.

journal_name

Genome Biol

journal_title

Genome biology

authors

Rasmussen M,Sundström M,Göransson Kultima H,Botling J,Micke P,Birgisson H,Glimelius B,Isaksson A

doi

10.1186/gb-2011-12-10-r108

subject

Has Abstract

pub_date

2011-10-24 00:00:00

pages

R108

issue

10

eissn

1474-7596

issn

1474-760X

pii

gb-2011-12-10-r108

journal_volume

12

pub_type

杂志文章

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